Patents Examined by Alexander Kim
  • Transcription factors for cellulosic enzyme production
    Patent number: 9441255
    Abstract: Provided herein are methods and compositions for increasing the production of one or more cellulases from a fungal host cell. The disclosure is based, on the surprising discovery that mis-expression of the transcriptional regulator clr-2 in a filamentous fungal cell was able to induce expression of cellulase genes under non-inducing or starvation conditions, resulting in increased secretion of cellulases from the cell. Advantageously, mis-expression of the transcription factor clr-2 in a filamentous fungal cell cultured in the absence of cellulose or cellobiose results in increased secretion of cellulases.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: September 13, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chaoguang Tian, Teresa Shock, N. Louise Glass, Samuel Coradetti, James Craig
  • Process for butanol production
    Patent number: 9434963
    Abstract: This invention comprises a process for the bioconversion of a fermentable carbon source to n-butanol by a microorganism, wherein the microorganism is deficient in at least one gene or protein involved in the four-carbon compounds pathway regulation to improve the four-carbon compounds pathway, particularly by inactivation of the transcriptional repressor rex.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: September 6, 2016
    Assignee: METABOLIC EXPLORER
    Inventor: Assia Zigha
  • Modified host cells with efflux pumps
    Patent number: 9428726
    Abstract: The present invention provides for a modified host cell comprising a heterologous expression of an efflux pump capable of transporting an organic molecule out of the host cell wherein the organic molecule at a sufficiently high concentration reduces the growth rate of or is lethal to the host cell.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: August 30, 2016
    Assignee: The Regents of the University of California
    Inventors: Mary J. Dunlop, Jay D. Keasling, Aindrila Mukhopadhyay
  • DNA polymerases with improved activity
    Patent number: 9428782
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 30, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Shawn Suko
  • phi29 DNA polymerase mutants having increased thermostability and processivity
    Patent number: 9422535
    Abstract: Mutants of bacteriophage phi29 DNA polymerase with increased protein stability and increased half-life, compared to wild type DNA polymerase. The disclosed mutants are more stable in reaction mixtures with or without DNA. The inventive phi29 DNA polymerase mutants generate more amplification product. The inventive phi29 DNA polymerase mutants amplify genomic DNA with less bias compared to wild type DNA polymerase. Selected mutations increase the affinity of polymerase for DNA template.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 23, 2016
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Remigijus Skirgaila, Tadas Povilaitis
  • Pericarp DNA extraction and matrilineage determination
    Patent number: 9416394
    Abstract: Methods for separating pericarp tissue from surrounding tissues in grain are provided. Included are methods for isolation of high-purity pericarp DNA from a grain plant that reflects the genotype of the maternal parent of the grain plant, such that the isolated DNA may be used in a PCR-based genotyping assay.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: August 16, 2016
    Assignee: Agrigenetics, Inc.
    Inventors: Brandon Rapier, Amy Pierce, Jennifer Hamilton, Ana Paula Canu, Juan Pablo Raimondi, Thomas G. Patterson, Nitigna Heath
  • Thermostable carbonic anhydrases and methods of use thereof
    Patent number: 9410140
    Abstract: The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or use thereof. Formulations containing the carbonic anhydrase are suitable for use in extracting carbon dioxide.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: August 9, 2016
    Assignee: DANISCO US INC
    Inventors: Jing Ge, Ling Hua, Ayrookaran J. Poulose
  • Enhanced heterologous production of lipoxygenases
    Patent number: 9404095
    Abstract: The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: August 2, 2016
    Assignee: US NewWin, Inc.
    Inventors: Gaofeng Liu, Min-ju Chang, Averell L. Gnatt, Tian Ye
  • Method for purifying albumin
    Patent number: 9403898
    Abstract: An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate comprising albumin, a variant or fragment thereof is disclosed.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: August 2, 2016
    Assignee: NOVOZYMES BIOPHARMA DK A/S
    Inventors: Lee Edward Blackwell, Jason Cameron, Phillip Harvey Morton, Steven James Burton, Richard Anthony Dodd, Mark Jonathan Burton
  • Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases
    Patent number: 9399770
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: July 26, 2016
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein
  • Cyclic peptide production
    Patent number: 9394561
    Abstract: An enzyme useful for producing cyclic peptides from linear peptide precursors and a gene encoding the enzyme are described. The enzyme is particularly useful for producing segetalins from linear presegetalin precursors. The linear presegetalin precursors may be derived from other linear presegetalin precursors farther upstream in the biosynthetic synthesis of the segetalin.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: July 19, 2016
    Assignee: National Research Council of Canada
    Inventors: Carla Jann Siobhan Barber, Darwin Wilfred Reed, Janet Anne Condie, Sheila Diniwe Sherin Chiwocha, Patrick Smithers Covello
  • Human growth hormone crystals and methods for preparing them
    Patent number: 9376479
    Abstract: The present invention relates to stable, extended release crystals of human growth hormone or a human growth hormone derivative and compositions or formulations comprising such crystals. The invention further provides methods for producing those crystals and compositions. The invention further provides methods for treatment of an individual having disorders associated with human growth hormone deficiency or which are ameliorated by treatment with human growth hormone using those crystals and compositions or formulations.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: June 28, 2016
    Assignee: Anjinomoto Althea, Inc.
    Inventors: Chandrika Govardhan, Nazer Khalaf, Benjamin Paul Simeone
  • DNA element having the activity of enhancing foreign gene expression
    Patent number: 9371543
    Abstract: A method for stably achieving high expression of a foreign gene in mammalian cells using a novel DNA element is disclosed. More specifically, the present application discloses a DNA element which enhances the activation of transcription by changing the chromatin structure around a gene locus into which a foreign gene expression unit has been introduced.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: June 21, 2016
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Daisuke Nishimiya, Tatsuya Inoue
  • Factor VIII conjugates
    Patent number: 9364520
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: June 14, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Clark Q. Pan, John E. Murphy, Baisong Mei, Jonathan S. Strauss, Hendri Tjandra, Jianmin Chen, Thomas Barnett, Liang Tang, Deqian Wang
  • Activated collagen scaffold materials and their special fused active restoration factors
    Patent number: 9365617
    Abstract: Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:4 at N-terminus.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 14, 2016
    Assignee: YANTAI ZHENGHAI BIO-TECH CO., LTD
    Inventors: Jianwu Dai, Bing Chen, Hang Lin, Wenjie Sun, Wenxue Zhao
  • Microbial metabolism of chlorine oxyanions as a control of biogenic hydrogen sulfide production
    Patent number: 9365845
    Abstract: The present disclosure relates to methods of controlling the sulfide (S2˜) content in systems, such as oil and gas reservoirs and pipelines, by the use of chlorine oxyanions and microorganisms with (per)chlorate-reducing activity.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: June 14, 2016
    Assignee: The Regents of the University of California
    Inventor: John D. Coates
  • Activated collagen scaffold materials and their special fused active restoration factors
    Patent number: 9359403
    Abstract: Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:12 at N-terminus.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 7, 2016
    Assignee: YANTAI ZHENGHAI BIO-TECH CO., LTD
    Inventors: Jianwu Dai, Bing Chen, Hang Lin, Wenjie Sun, Wenxue Zhao
  • Lipid therapy
    Patent number: 9358268
    Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: June 7, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
  • Detection apparatus for differential-charged particle mobility analyzer
    Patent number: 9354200
    Abstract: The present invention provides devices and methods for identification and/or quantitation of particles through detection of fluorescence labeled particles in an apparatus for differential charged particle mobility analysis and fluorescence detection.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: May 31, 2016
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventor: Michael P. Caulfield
  • Selectively targeted antimicrobial peptides and the use thereof
    Patent number: 9351490
    Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 31, 2016
    Assignee: The Regents of the University of California
    Inventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy