Patents Examined by Caralynne E Helm
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Patent number: 11938228Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.Type: GrantFiled: January 7, 2019Date of Patent: March 26, 2024Assignee: PRIVO TECHNOLOGIES, INC.Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amritpreet Birdi
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Patent number: 11931485Abstract: A biocompatible and bioresorbable implantable device that is intended to be deployed in the middle meningeal artery through intra-arterial catheters and release an anesthetic agent for a prolonged period into the branches of the middle meningeal artery to treat severe headaches including migraine and trigeminal neuralgias. The implantable device may be a mesh with multiple helical loops, fenestrated collapsible hollow shell or spheroid, or folded sheath.Type: GrantFiled: March 9, 2021Date of Patent: March 19, 2024Inventor: Adnan I. Qureshi
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Patent number: 11931369Abstract: Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.Type: GrantFiled: July 24, 2023Date of Patent: March 19, 2024Assignee: POVIVA CORPInventors: John Docherty, Christopher Andrew Bunka
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Patent number: 11896738Abstract: An electrically conductive hyaluronic acid-based hydrogel is disclosed that is a crosslinked porous scaffold having a graphene-based material encapsulated or in contact within the porous scaffold. The graphene-based material includes one or more of graphene oxide foam, reduced graphene oxide foam, nanoplatelets, nanoparticles, or fibers. The porous scaffold may be formed over an implanted bioelectronic device such as a microelectrode array having a plurality of electrodes. The porous scaffold may also be used to control the differentiation of cells including Neural Stem/Progenitor Cells (NS/PCs).Type: GrantFiled: March 10, 2021Date of Patent: February 13, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Rebecca Bierman
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Patent number: 11878013Abstract: The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.Type: GrantFiled: July 2, 2021Date of Patent: January 23, 2024Assignee: Korea Research Institute of Chemical TechnologyInventors: Myung-Ae Bae, Dae-Seop Shin, Jung Yoon Yang, Kyu Seok Hwang, Seong Soon Kim, Byung Hoi Lee, Ki Young Kim, Won Hoon Jung, Jae Chun Woo
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Patent number: 11806320Abstract: Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics. In preferred aspects, formulations are terminally sterilized and packaged in a suitable format, such as a polymeric bag with metalized overwrap and include a non-contact oxygen scavenger.Type: GrantFiled: February 18, 2021Date of Patent: November 7, 2023Assignee: ENDO VENTURES LIMITEDInventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
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Patent number: 11752098Abstract: Disclosed are compositions and methods for microneedle patches comprising diblock copolymer micelles designed for pH cascade and H2O2 triggered insulin delivery.Type: GrantFiled: October 10, 2018Date of Patent: September 12, 2023Assignee: North Carolina State UniversityInventors: Zhen Gu, Jinqiang Wang
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Patent number: 11707483Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.Type: GrantFiled: September 23, 2019Date of Patent: July 25, 2023Assignees: UNIVERSITY OF WASHINGTON, GENEVANT SCIENCES GMBHInventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
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Patent number: 11684703Abstract: Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor.Type: GrantFiled: February 20, 2019Date of Patent: June 27, 2023Assignee: Qura, Inc.Inventors: Douglas P. Adams, Amitava Gupta
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Patent number: 11607383Abstract: The present disclosure describes a method of delivering a therapeutic agent providing a microneedle array including a plurality of microneedles, the plurality of microneedles including a conductive coating disposed thereon, wherein the conductive coating includes the therapeutic agent and a conducting polymer; implanting the microneedle array in a dura mater of a subject in need thereof, wherein the microneedle array pierces the dura mater; and applying an electrical stimulus to the microneedle array to provide a controlled release of the therapeutic agent from the conductive coating, across the dura mater, to the central nervous system of the subject.Type: GrantFiled: October 13, 2020Date of Patent: March 21, 2023Assignee: University of WashingtonInventors: Rajiv Saigal, Joyce Huang
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Patent number: 11602721Abstract: A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.Type: GrantFiled: January 6, 2020Date of Patent: March 14, 2023Assignee: THE SECANT GROUP, LLCInventors: Steven Lu, Peter D. Gabriele, Julia Donnelly, Brian Ginn, Charles Brendan Nicholson, Jeremy J. Harris, Michael S. Flemmens
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Patent number: 11590064Abstract: The present invention provides an anhydrous, sprayable sunscreen composition comprising one or more oil soluble UV filters and a combination of film formers comprising at least one copolymer of trimethylolpropane, adipic acid, neopentyl glycol and hexanediol and at least one acrylates/octylacrylamide copolymer having a molecular weight of at least 50 kDA measured using Dynamic Light Scattering.Type: GrantFiled: October 4, 2019Date of Patent: February 28, 2023Assignee: Johnson & Johnson Consumer Inc.Inventors: Navya Mudya, Frank C. Sun
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Patent number: 11571372Abstract: A cosmetic ingredient including at least one plant squalane and at least one mixture of C24 to C48 alkanes, in at least dimeric form, chosen amongst the alkanes of formula (I), where n is 1 or 0, R1, R?1, R2, R?2, R3 and R?3, which may be identical or different, are chosen amongst hydrogen atoms, methyl radicals, and linear C8 to C30 alkyl radicals, at least one of R1, R?1, R2, R?2, R3 and R?3 is chosen amongst the linear C8 to C30 alkyl radicals, and at least one and at most one of R1, R?1, R2, R?2, R3 and R?3 is a methyl radical. The mixture of C24 to C48 alkanes have a viscosity between 12 and 25 mm2/s at 40° C.Type: GrantFiled: May 18, 2020Date of Patent: February 7, 2023Assignee: BIOSYNTHISInventors: Thierry Bernoud, Julien Magne, Antoine Piccirilli
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Patent number: 11517512Abstract: Disclosed herein are personal care compositions comprising Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided. The personal care compositions may include a cleansing component and an antibacterial component, wherein the antibacterial component comprises Zn:usnate complexes having a 1:2 zinc to usnate molar ratio.Type: GrantFiled: July 16, 2018Date of Patent: December 6, 2022Assignee: Colgate-Palmolive CompanyInventors: Stanislav Jaracz, Long Pan, Karthik Sambanthamoorthy, Junhong Mao, Aixing Fan
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Patent number: 11504307Abstract: A biphasic topical product comprising a hydrophilic phase and a lipophilic phase floating on said hydrophilic phase. A method for preparing biphasic topical products.Type: GrantFiled: September 18, 2018Date of Patent: November 22, 2022Assignee: CMED AESTHETICS S.R.L.Inventor: Elena Bottai
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Patent number: 11504395Abstract: The invention is concerned with use of oral inorganic pyrophosphate for preventing and/or reducing tissue calcification, particularly soft tissue calcification, and/or diseases or disorders characterized by low plasma PPi levels, as, e.g.Type: GrantFiled: September 13, 2017Date of Patent: November 22, 2022Assignee: Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek ZiekenhuisInventors: András Váradi, Dóra Dedinszki, Flóra Mária Szeri, Piet Borst, Jan Koenraad Van De Wetering
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Patent number: 11478429Abstract: A two-compartment capsule includes a body, a diaphragm between, which seals off the body and provides a first compartment to hold a first dry ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second dry ingredient. This disclosure also provides particular formulations for use in such a capsule. Examples include a probiotic, a digestive enzyme, an expectorant, a bronchodilator, a stool softener, a platelet aggregation inhibitor, a form or derivative of vitamin E, a statin, and aspirin.Type: GrantFiled: October 10, 2016Date of Patent: October 25, 2022Assignee: ComboCap, Inc.Inventor: Tobias Johan Louw
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Patent number: 11464719Abstract: Cosmetic and dermatological compositions, including color changing compositions, are provided which typically include a plurality of synthetic particles having a size in the micrometer or nanometer range. Each synthetic particle typically includes one or more aggregates of a pigment selected from phenoxazone, phenoxazine, and a derivate or precursor thereof, and a stabilizing material which has a refractive index larger than 1.45; the aggregates having a size larger than about 100 nm and the composition being biodegradable and biocompatible.Type: GrantFiled: September 25, 2018Date of Patent: October 11, 2022Assignee: Northeastern UniversityInventors: Leila Deravi, Camille A. Martin, Amrita Kumar
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Patent number: 11406592Abstract: An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.Type: GrantFiled: October 23, 2018Date of Patent: August 9, 2022Assignee: Mati Therapeutics Inc.Inventors: Eugene de Juan, Jr., Cary Reich, Stephen Boyd, Hanson S. Gifford, III, Mark Deem
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Patent number: 11406742Abstract: A coating for an expandable portion of a catheter comprising a lipophilic matrix and a plurality of micro-reservoirs dispersed in the lipophilic matrix is disclosed. The plurality of micro-reservoirs comprises an active agent. A coating formulation and a method for forming the coating are also disclosed. A catheter comprising the coating on the expandable portion and a method for treating a condition are also provided.Type: GrantFiled: October 15, 2018Date of Patent: August 9, 2022Assignee: M.A. Med Alliance SAInventors: Michael Thomas Ahlering, Ronald Kenichi Yamamoto, Robert John Elicker, Tien Thuy Nguyen, John Edwin Shulze, Jelle Jurjen Zoethout