Abstract: The present invention relates to an aerosol hairspray product. The product comprises: a pressurizable container comprising a container wall which encloses a reservoir for storing a hairstyling formulation and a liquefied gas propellant; and a spraying device attached to the container for dispensing the hairstyling formulation from the reservoir of the container. The spraying device comprises a valve and a nozzle and the valve comprises a valve body, a stem and a spring means. The valve body houses an insert and the insert comprises an insert orifice and at least two channels. The channels are tangentially disposed about the insert orifice. Also the valve body comprises at least two vapor taps. Furthermore the insert orifice is capable of being in liquid communication with the hairstyling formulation in the reservoir.

Abstract: The present invention relates to methods of forming miniemulsions and use of the miniemulsions as a delivery system for bioactive agents. In particular, the present invention relates to methods for forming a miniemulsion comprising providing a first phase comprising a hydrophilic surfactant, lipophillic surfactant and water and a second phase comprising a lipid, wherein said miniemulsion comprises emulsified particles having a mean diameter of 1 ?m or less.

Abstract: Therapeutic agent delivery systems, which include a thermally-sensitive copolymer and optionally a therapeutic agent, are disclosed. The copolymer is water soluble and biodegradable and, in accordance with exemplary embodiments, includes hydrophobic and hydrophilic portions. The systems may include supplemental compounds, such as polymeric nanoparticles, micelle compounds, or a combination thereof, to further provide sustained release of the therapeutic agent.

Abstract: Disclosed herein are bactericidal compositions that are effective against pathogenic biofilms, especially against biofilms formed by Pseudomonas aeruginosa. The disclosed compositions comprise escapin intermediate products which can reduce the biofilm viability and biofilm matrix of P. aeruginosa.

Abstract: The invention concerns a storage stable pharmaceutical preparation comprising oxycodone and naloxone for use in pain therapy, with the active compounds being released from the preparation in a sustained, invariant and independent manner.

Abstract: A water-based composition containing oil soluble components may include an anhydrous concentrate including hydroxypropylcocoate PEG-8 dimethicone and a hydration component, which may be stored in separate vessels prior to mixing. The anhydrous concentrate may be combined with the hydration component to create a consumer product such as a topical cream. The anhydrous concentrate may include a preparation that includes a liquid dispersion polymer, an inverting surfactant and a binding agent, and also may include lipid-soluble vitamins, antioxidants and the like. The hydration component may include water and a preservative system, and also may include water-soluble vitamins, antioxidants and the like. Two forms (i.e. lipid-soluble and water-soluble) of a given ingredient (such as vitamin C) may be provided in the concentrate and the hydration component, respectively.

Abstract: The present invention relates to a process for preparing a colored lamellar composition that may provide a wide range of colors. The process includes the steps of dispersing a colorant in a hydrocarbon, grinding the dispersed colorant to a particle size of less than about 1 micron (?m), and spraying the colorant onto a lamellar substrate to provide the colored lamellar composition while mixing and heating the lamellar composition to remove the hydrocarbon.

Abstract: Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.