Abstract: Better Pareto dose distributions for multi-criteria optimization of treatment plans can be obtained by obtaining at least one reference dose function designed to result in an acceptable reference dose distribution, defining a multi-criteria optimization problem including the at least one reference dose function as at least one optimization function, performing at least two optimization procedures based on the multi-criteria optimization problem to generate a set of at least two possible treatment plans, obtaining a treatment plan to be used for treating the patient, based on the set of possible treatment plans, by selecting one plan or by combining plans.

Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.

Abstract: A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: A system and method for thought-based control of sexual stimulation devices using electroencephalography. The system and method involve a training phase and an operation phase. In an embodiment, the training phase comprises placing electrodes on the head of a person, measuring electrical signals produced by the person's brain via the electrodes while the user engages in one or more thought-based training tasks, associating patterns of electrical activity in the person's brain while performing the tasks with controls of the sexual stimulation device. In an embodiment, the operation phase comprises generating control signals for the sexual stimulation device based on the associations when the patterns of electrical activity are detected by the electrodes. In some embodiments, machine learning algorithms are used to detect the patterns of electrical activity and make the associations. In some embodiments, data from other biometric sensors is included in the associations.

Abstract: Aspects of the present disclosure provide a smart relaxation mask configured to output a stimulus and collect biometric information while the stimulus is output to determine if the subject is paying attention to the stimulus. If the subject is not focused on the stimulus, the mask adjusts at least one of an audio, visual, or haptic output. The stimulus is adjusted in an effort to shift the subject's attention to the stimulus and away from racing thoughts.

Abstract: A system and method for automated generation of control signals for sexual stimulation devices from usage history and other data. The system and method involve analyzing historical usage and other data for a user for a device or devices, processing the data through machine learning algorithms, and generating new or recombined patterns of stimulation based on the outputs from the machine learning algorithms. The resulting automated control signals represent partially or fully customized stimulation for a given user which evolve over time as the user continues to use the device or devices.

Abstract: A neutron capture therapy system includes a neutron beam generating unit, an irradiation room configured to irradiate an irradiated body with a neutron beam, a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, and an auxiliary positioner disposed in the irradiation room and/or the preparation room. The irradiation room includes a first shielding wall, a collimator is disposed on the first shielding wall for emitting the neutron beam, and the neutron beam is emitted from the collimator and defines a neutron beam axis. The auxiliary positioner includes a laser emitter that emits a laser beam to position the irradiated body, wherein the position of the laser emitter is selectable. Therefore, the irradiated body can be positioned in any case to implement precise irradiation.

Abstract: A method for machine learning based artifact rejection is provided. The method may include applying a machine learning model to identify artefactual independent components in transcranial magnetic stimulation electroencephalogram data collected during a transcranial magnetic stimulation procedure. Clean transcranial magnetic stimulation electroencephalogram data is generated by removing, from the transcranial magnetic stimulation electroencephalogram data, the artefactual independent components. Real-time adjustments to parameters of the transcranial magnetic stimulation procedure may be performed based on the clean transcranial magnetic stimulation electroencephalogram data. Related systems and articles of manufacture, including computer program products, are also provided.

Abstract: An essential oil diffusion mechanism, including: a housing having an accommodation chamber; and a separator that divides the accommodation chamber into an upper chamber and a lower chamber and includes a horizontal partition plate and vertical partition plates. The horizontal partition plate defines at least one interconnecting hole. An upper surface of each vertical partition plate is spaced apart from a chamber wall of the upper chamber to form an upper interconnecting aperture. Each vertical partition plate defines an interconnecting reflux hole. A lower surface of each baffling plate is spaced apart from the horizontal partition plate to form a lower interconnecting aperture. The interconnecting hole, the upper interconnecting aperture, the lower interconnecting aperture, and the air outlet are sequentially arranged in communication to form an air outlet channel.

Abstract: A prosthesis including an abutment, an operationally removable component including a coupling apparatus, and an adapter, wherein the abutment is connected to the adapter and the coupling apparatus of the operationally removable component is releasably coupled to the adapter.

Abstract: A fragrance suitable for a user can be provided. A mobile terminal includes: an acquisition unit that acquires a psychosomatic state from a physiological index of a user; an input unit that inputs future information of the user; a determination unit that determines a recipe including one or more types and a mixing ratio of one or more perfumes based on the psychosomatic state and the future information; and a communication unit that transmits the recipe to a fragrance generation device.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are methods of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: A method facilitates altering consciousness by transcranial stimulation to adjust the membrane potential duration of sensory cortex dendritic spine necks. Sensory cortex spine neck membranes are conscious. The method comprises the steps of placing electrodes on or near a scalp; applying electric fields to spine neck membranes in sensory cortex; adjusting stimulation parameters; and altering consciousness for a predetermined duration.

Abstract: The subject of the invention is a system for inducing an electric field in a conducting medium, especially for medical applications. The system according to the invention induces a flow of electric current through objects located in the conducting medium, which may have shapes that are complex or change with time, and has a medical application consisting in a complete or partial nerve impulse block. The system for inducing an electric field in the conducting medium comprises at least two component cores, whose magnetization is configured to be changed independently by a change of electric currents flowing through windings that are wound around them, and a torus-shaped encasement whose outer surface is electrically non-conductive, wherein the component cores are situated inside the encasement and encircle its opening, and the encasement is situated inside the conducting medium.

Abstract: A pressure injuries therapeutic support surface is illustrated. The surface comprises an integrated system designed for a concurrent physical and psychoneuroimmunological approach over a user, wherein the system comprises one or a plurality of independent fluid-filled main chambers, made of waterproof, flexible, extendable, and elastic material and at least two accessory chambers connected to each main chamber with at least with two free-flow conduits. The system is managed through a powered mechatronic array with its own hardware and software based on microcontrollers for the simultaneous operation of specific multidisciplinary devices.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an elongate shaft having a proximal end region and a distal end region. A first lumen may be defined in the shaft. A second lumen may be defined in the shaft. The distal end region may include a common lumen region in fluid communication with the first lumen and the second lumen. A deflectable member may be disposed within the shaft. The deflectable member may be designed to shift between a first configuration where the deflectable member directs a first medical device disposed within the common lumen region into the first lumen and a second configuration where the deflectable member allows a second medical device to move between the common lumen region and the second lumen.

Abstract: Techniques for generating radiotherapy treatment plans and establishing machine learning models for the generation and optimization of radiotherapy dose data are disclosed. An example method for generating a radiotherapy dose distribution using a generative model, trained in a generative adversarial network, includes: receiving anatomical data of a human subject that indicates a mapping of an anatomical area for radiotherapy treatment; generating radiotherapy dose data corresponding to the mapping with use of the trained generative model, as the generative model processes the anatomical data as an input and provides the dose data as output; and identifying the radiotherapy dose distribution for the radiotherapy treatment of the human subject based on the dose data.

Abstract: The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range T1 while another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T2.

Abstract: Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.