Patents Examined by D. L. Dinner
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Patent number: 4789680Abstract: 1-phenyl-lower alkyl-1H-1,2,3-triazole compounds of the formula ##STR1## in which Ph represents phenyl substituted by up to and including 3 substituents selected from lower alkyl, halogen and trifluoromethyl, alk represents lower alkylidene, and wherein eitherR.sub.1 represents hydrogen, lower alkyl, lower alkoxy, amino, N-lower alkylamino, N,N-di-lower alkylamino, N-lower alkanoylamino, carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl andR.sub.2 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl orR.sub.1 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl andR.sub.2 represents hydrogen or lower alkyl,have anti-convulsive properties and can be used as medicaments.Type: GrantFiled: October 20, 1986Date of Patent: December 6, 1988Assignee: Ciba-Geigy CorporationInventor: Rene Meier
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Patent number: 4783474Abstract: Novel halogenoalkyl-, alkenyl- and alkinyl-azoles of the formula ##STR1## in which X represents a nitrogen atom or a CH grouping,R represents optionally substituted tert.-alkyl or optionally substituted cycloalkyl, andA represents one of the groupings --C.tbd.C--, ##STR2## in which R.sup.1 represents halogen, alkoxy or trialkylsilyloxy,R.sup.2 represents hydrogen or halogen, andR.sup.3 represents halogen,and acid and metal salt addition products thereof synergize insecticides and herbicides which function by photosynthesis inhibition.Type: GrantFiled: October 2, 1987Date of Patent: November 8, 1988Assignee: Bayer AktiengesellschaftInventors: Udo Kraatz, Wolfgang Behrenz, Carl Fedtke
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Patent number: 4777175Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.Type: GrantFiled: September 15, 1986Date of Patent: October 11, 1988Assignee: Warner-Lambert CompanyInventors: Townley P. Culbertson, John M. Doma, Thomas F. Mich, Jeffrey B. Nichols
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Patent number: 4776877Abstract: Triazolyl-alkanones or triazolyl-alkanols of the formula ##STR1## in which R.sup.1 is alkyl, cycloalkyl, aryl or substituted aryl, andR.sup.2 is hydrogen, alkyl, cycloalkyl, aryl or substituted aryl, orR.sup.1 and R.sup.2 are joined to form an aliphatic ring, andA is a keto group or a CH(OH) group,or a salt thereof which possess fungicidal, microbicidal and plant-growth regulating properties.Type: GrantFiled: August 10, 1981Date of Patent: October 11, 1988Assignee: Bayer AktiengesellschaftInventors: Helmut Timmler, Wolfgang Kramer, Karl H. Buchel, Helmut Kaspers, Wilhelm Brandes
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Patent number: 4775689Abstract: This invention relates to novel 5-(naphthyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and to their use as antidepressants.Type: GrantFiled: July 28, 1987Date of Patent: October 4, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: John M. Kane, Francis P. Miller
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Patent number: 4775688Abstract: This invention relates to novel 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.Type: GrantFiled: May 15, 1987Date of Patent: October 4, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: John M. Kane, Francis P. Miller
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Patent number: 4771065Abstract: A fungicidally active substituted phenethyl-triazolyl derivative of the formula ##STR1## in which X.sup.1 and X.sup.2 each independently is halogen or halogenoalkyl, and one of them may also be hydrogen,Y is >C.dbd.N--O--R or >CH--O--R,R is phenoxyethyl which is optionally substituted in the phenyl part,or an addition product thereof with an acid or salt.Type: GrantFiled: March 13, 1984Date of Patent: September 13, 1988Assignee: Bayer AktiengesellschaftInventors: Wolfgang Kramer, Hans-Joachim Knops, Karl H. Buchel, Paul Reinecke
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Patent number: 4767777Abstract: A triazole of the formula ##STR1## wherein R is phenyl substituted by difluoro, fluoro, dichloro or chloro and R' is phenyl substituted by chloro or fluoro are useful antifungal agents.Type: GrantFiled: November 14, 1985Date of Patent: August 30, 1988Assignee: Pfizer Inc.Inventors: Robert J. Bass, Kelvin Cooper, Kenneth Richardson
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Patent number: 4762846Abstract: A derivative of phencyclidine (1) bearing an isothiocyanate moiety on the meta position of the aromatic ring (3; Metaphit as methanesulfonate and HCl salt) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates. Additional related compounds to Metaphit are Thiophit (oxalate salt), Ethylphit (HCl salt), and Isopropylphit (HCl salt).Type: GrantFiled: January 31, 1986Date of Patent: August 9, 1988Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Kenner C. Rice, Michael F. Rafferty, Arthur E. Jacobson, Patricia Contreras, Thomas L. O'Donohue, Ralph A. Lessor, Mariena V. Mattson
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Patent number: 4758262Abstract: This invention relates to herbicidally active propylene oxide derivatives, agriculturally suitable compositions thereof, and a method of using them as herbicides or plant growth regulants.Type: GrantFiled: December 13, 1985Date of Patent: July 19, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Rafael Shapiro
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Patent number: 4752611Abstract: There are disclosed certain 1,2,3-triazole compounds with a substituted benzyl group at the 1-position, an amido group at the 4-position and a aminomethylene amino group at the 5-position. The compounds are prepared from the corresponding compound wherein the 5-position substituent is amino by treatment with a formimido acetal. The compounds are active anticoccidial agents.Type: GrantFiled: November 29, 1985Date of Patent: June 21, 1988Assignee: Merck & Co., Inc.Inventor: Donald W. Graham
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Patent number: 4747869Abstract: Substituted azoyl-ketones and -alcohols of the formula ##STR1## in which A is a nitrogen atom or the CH group,B is CO or CH(OH),R.sup.1 is alkyl, alkenyl, alkinyl, optionally substituted phenylalkyl, optionally substituted cycloalkyl or optionally substituted cycloalkylalkyl,R.sup.2 is optionally substituted cycloalkyl or the grouping --C(CH.sub.3).sub.2 R.sup.3, andR.sup.3 is alkyl having more than 2 carbon atoms, alkenyl, alkinyl or the --CH.dbd.O group or a derivative thereof,or addition products thereof with acids or metal salts, exhibit plant growth regulating and fungicidal properties, several intermediates therefor are new.Type: GrantFiled: April 18, 1985Date of Patent: May 31, 1988Assignee: Bayer AktiengesellschaftInventors: Wolfgang Kramer, Karl H. Buchel, Klaus Ditgens, Hans-Ludwig Elbe, Gerhard Jager, Manfred Jautelat, Klaus Lurssen, Paul Reinecke
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Patent number: 4744817Abstract: Novel triazole of the formula ##STR1## in which R represents alkyl, cycloalkyl or the groupings ##STR2## wherein X.sup.1 represents hydrogen or halogen,X.sup.2 represents halogen,Y represents alkoxy, alkylthio, halogenoalkoxy, halogenoalkylthio, alkenyl, alkoxycarbonyl, cyano, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylthio, optionally substituted phenylalkoxy or optionally substituted phenylalkylthio andn represents the number 0, 1 or 2,Z represents halogen, alkyl, halogenoalkyl, halogenoalkoxy, halogenoalkylthio or phenyl andm represents the number 0, 1, 2, or 3,or addition products thereof with acids and metal salts, which exhibit fungicidal and plant growth-regulating activity.Type: GrantFiled: March 3, 1986Date of Patent: May 17, 1988Assignee: Bayer AktiengesellschaftInventors: Graham Holmwood, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes, Gerd Hanssler
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Patent number: 4743291Abstract: Herbicidal aryl triazolinones include the compounds of the formula ##STR1## where X is preferably halogen such as fluorine, Y is preferably halogen such as chlorine, R.sup.1 is preferably methyl, R.sup.2 is preferably CHF.sub.2, R.sup.3 is preferably CH(CH.sub.3), and ##STR2## is --NH.sub.2 or the residue of a primary or secondary amine or of a sulfonamide.Type: GrantFiled: May 5, 1986Date of Patent: May 10, 1988Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 4742078Abstract: A pyran derivative represented by a general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, cycloalkyl or phenyl, R.sub.2 is alkyl having 8 to 20 carbon atoms, R.sub.3 is hydrogen, halogen, ##STR2## R.sub.4 and R.sub.5 being each lower alkyl or cycloalkyl, A being --CH.sub.2 --, oxygen or nitrogen atom, ##STR3## forms five or six-member ring (the ring may have no substituent or have at least one substituent selected from lower alkyl, lower alkoxy and halogen atom), or an acid salt thereof, are useful as agricultural miticides.Type: GrantFiled: October 20, 1986Date of Patent: May 3, 1988Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Hisashi Takao, Norio Osaki, Norio Yasudomi
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Patent number: 4742071Abstract: 2-Aryl-2-azolylmethyl-1,3-dioxepines of the formula ##STR1## in which Az is imidazol-1-yl or 1,2,4-triazol-1-yl,X is the ethylene or vinylene grouping, andAr is optionally substituted aryl, or addition products thereof with acids or metal salts, which possess fungicidal activity.Type: GrantFiled: July 25, 1985Date of Patent: May 3, 1988Assignee: Bayer AktiengesellschaftInventors: Udo Kraatz, Gerhard Jager, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke, Hans-Dieter Scharf, Herbert Frauenrath
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Patent number: 4742072Abstract: This invention relates to 1-dimethylcarbamoyl-3-t-butyl-5-(carboalkoxy)-alkylthio-1H-1,2,4-triazoles as defined herein, compositions containing those compounds and methods of use.Type: GrantFiled: July 25, 1985Date of Patent: May 3, 1988Assignee: Rohm and Haas CompanyInventors: Richard M. Jacobson, Muthuvelu Thirugnanam
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Patent number: 4740515Abstract: 3-(1,2,4-Triazol-1-yl)-prop-1-enes of the general formula (I) ##STR1## in which X.sup.1 and X.sup.2 independently of one another represent hydrogen or methyl,R.sup.1 represents alkyl, alkenyl, in each case optionally substituted cycloalkyl or cycloalkenyl or in each case optionally substituted phenyl or benzyl andR.sup.2 represents alkyl, alkenyl, in each case optionally substituted cycloalkyl or cycloalkenyl, halogenoalkyl, in each case optionally substituted phenyl or phenylalkyl, phenoxyalkyl or phenylthioalkyl, in each case optionally substituted in the phenyl part,but whereinR.sup.1 and R.sup.2 may not simultaneously represent optionally substituted phenyl if X.sup.1 and/or X.sup.2 represent hydrogen,and acid addition salts and metal salt complexes thereof which are tolerated by plants, exhibit fungicidal activity.Type: GrantFiled: July 18, 1984Date of Patent: April 26, 1988Assignee: Bayer AktiengesellschaftInventors: Joachim Weissmuller, Wolfgang Kramer, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke
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Patent number: 4740364Abstract: A method of providing a diagnostic indicia which is predictive of the risk of a non-osteoporotic human being contracting osteoporosis as a consequence of being in a long-term hormonally agonadal state, which comprises the steps of determining the average ratio of calcium to creatinine in the urine or in the blood of that person, during a period when the person is ingesting only foodstuff sources of calcium and vitamin D, while in a hormonally gonadal state, and also while in a hormonally agonadal state; determining the magnitude of the difference in the ratio obtained in the latter state compared to the former state, a large difference being predictive of a high risk of that person contracting osteoporosis.Type: GrantFiled: September 27, 1985Date of Patent: April 26, 1988Assignee: Eastern Virginia Medical AuthorityInventor: Gary D. Hodgen
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Patent number: 4739081Abstract: The invention relates to new crown ether derivatives of the general Formula I ##STR1## and a process for the preparation thereof wherein Z.sup.1 is a group of the general Formula ##STR2## R.sub.a and R.sub.b may be the same or different and R.sub.a represents an alkyl group having 1-4 carbon atoms and R.sub.b is an alkyl group having 1-20 carbon atoms.The new crown ethers are useful in the preparation of ion-selective electrodes having a long lifetime.Type: GrantFiled: November 1, 1984Date of Patent: April 19, 1988Assignee: Magyar Tudomanyos AkademiaInventors: Laszlo Toke, Bela gai, Istvan Bitter, Erno Pungor, Klara Szepesvary nee Toth, Erno Lindner, Maria Forro nee Horvath, Jeno Havas