Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, unsubstituted benzyl or benzyl substituted with halogen methyl, ethyl, propyl, butyl, nitro, trifluoromethyl, cyano, methoxy, ethoxy, phenyl or methylenedioxy; R.sup.2 is hydrogen or C.sub.1 -C.sub.8 alkyl; Y is hydrogen, halogen, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy unsubstituted amino or methyl- or ethyl-substituted amino, and n is 1 or 2; each of the groups Y being the same or different when n is 2 and Y being other than hydrogen or halogen when R.sup.1 and R.sup.2 are both hydrogen; or a fungicidal acid salt or metal complex of said compound. Fungicidal compositions containing these compounds and methods of using the same to combat plant fungal diseases are also disclosed.

Abstract: Triazolo-benzodiazepine-1-ethanamines of the formulas ##STR1## where R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Ring A are as defined in the specification, e.g., 8-chloro-N,N-dimethyl-.beta.,6-diphenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benz odiazepine-1-ethanamine, and pharmacologically acceptable salts thereof, have been found to have substantial diuretic, natriuretic, but little, if any, kaliuretic activity, which can be used alone, or concomittently with other diuretic drugs such as furosemide or hydrochlorothiazide and/or with antihypertensive agents such as propranolol, captopril, minoxidil, prazosin, guanadrel sulfate, whose actions are supplemented by the action of a diuretic drug.

Abstract: The invention is a process for the preparation of a N- or S-1,2-ethylenically unsaturated organic compound which comprises(a) contacting a N- or S-silylated organic compound with an aldehyde, wherein the aldehyde has a hydrogen atom bonded to the carbon adjacent to the carbonyl moiety, at elevated temperatures under conditions such that a N- or S-1-siloxyalkyl-substituted organic compound is prepared; and(b) pyrolyzing the N- or S-1-siloxyalkyl-substituted organic compound under conditions such that the siloxy moiety is elminated to prepare a N- or S-1,2-ethylenically unsaturated compound.

Abstract: N-(Azolylcarbamyl)-hydroxylamines of the formula ##STR1## where R is unsubstituted or substituted alkyl, alkenyl, alkoxyalkyl or cycloalkyl, or unsubstituted or substituted phenyl, phenylalkyl, phenylalkenyl or phenoxyalkyl, R.sup.1 is alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl or unsubstituted or substituted benzyl, Y is CH or N and R.sup.2 and R.sup.3 are each hydrogen or alkyl, and fungicides which contain these compounds.

Abstract: Fused tetracyclic benzodiazepines of the formula (I): ##STR1## where R.sup.1 is a cyclic amine such as 1-piperazine and R.sup.2 is H or a substituent as defined herein are useful as LHRH antagonizing agents. Also, methods for their synthesis, intermediates used in such synthesis, methods for use as medicaments and pharmaceutical compositions are described.

Abstract: Substituted dihydroazepines, their preparation, and the use thereof as calcium channel blockers are disclosed.

Abstract: There are provided new substituted heterocyclic benzamides and derivatives hereof which provide modifications on the central nervous system.

Abstract: Oxiranes of the formula: ##STR1## in which R is ##STR2## R.sup.1 is hydrogen or halogen, R.sup.2 is halogen,R.sup.3 is alkyl with 1 to 4 carbon atoms or alkoxy with 1 to 4 carbon atoms,n is 0, 1 or 2,Y.sup.1 and Y.sup.2 each independently is hydrogen or alkyl with 1 to 4 carbon atoms,Z is halogen or alkyl with 1 to 4 carbon atoms, andm is 0 or 1.and useful as intermediates in the preparation of fungicides.

Abstract: This invention relates to novel compounds having the formula: ##STR1## wherein; R.sup.1 is fluoro, chloro, bromo, lower-alkyl or nitro,R.sup.2 is lower alkyl, lower alkoxy, fluoro, chloro, bromo, nitro or trifluoromethyl, andm and n are 0-2 with the proviso that when R.sup.1 or R.sup.2 are tertiary butyl or a sterically hindering lower alkyl radical, m and/or n are 1. These compounds are intermediates in the preparation of 2-aminobiphenylacetic acids, esters and metal salts thereof.

Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): ##STR1## wherein: n is 1 to 5;R is hydrogen or ##STR2## R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or methyl; andR.sup.3 is hydrogen, C.sub.1-5 alkyl or C.sub.1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino, or acetylamino; andthe dotted lines at a, b and c represent optional double bonds and pharmaceutically acceptable salts of the compounds (II) in which R.sup.3 is hydrogen are disclosed.

Abstract: Substituted aminoketals of the formula ##STR1## in which R.sup.1 to R.sup.4 are various organic radicals andR.sup.2 may also be hydrogen,are fungicidally active. Some of the compounds are new.

Abstract: Disclosed is a process for producing a heterocyclic compound having as the side chain group a nitromethylene group of the formula: ##STR1## wherein Y, R and n are as defined in the specification, which comprises reacting a 2,2-dihalonitroethylene compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Abstract: The invention provides novel .alpha.-aryl- or -aralkyl-.alpha.-(cycloalkyl-alkyl)-1H-azole-1-ethanols, in which the alkyl moiety linking the cycloalkyl group to the ethanol group is substituted or branched at the carbon atom adjacent to the C(OH) group, which are useful as plant fungicides and for treating fungus diseases in man and animals. Other objects of the invention are plant fungicidal, pharmaceutical and veterinary compositions comprising such novel compounds and methods of combatting phytopathogenic fungi or fungus diseases with the aid of said novel compounds.

Abstract: New tris-hydroxyalkyl triazolidine-3,5-diones are obtained by reacting triazolidine-3,5-dioxy with alkylene oxides.

Abstract: There are described microbicidally effective mandelic acid derivatives and mandelonitriles of the formula I ##STR1## wherein X is --CH.dbd. or --N.dbd.; Ar is phenyl, diphenyl or naphthyl group, which can be substituted in the form of the substituents R.sub.1 -R.sub.3 by nitro, halogen, alkyl, alkoxy or haloalkyl; R is any one of the groups --COOR.sub.5, --COSR.sub.6, --CON(R.sub.7)(R.sub.8) or CN; n is 0, 1 or 2; and R.sub.4 to R.sub.8 are aliphatic and aromatic and in part also heterocyclic substituents which are described in the text in greater detail; with the inclusion of the salts and metal complexes thereof.Also methods for producing these products are disclosed, and also pesticidal compositions containing as active ingredient one of these compounds. There is described too a method for combating phytopathogenic microorganisms with the aid of these substances.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof: ##STR1## R is phenyl, substituted phenyl, C.sub.3-6 cycloalkyl cyclohexenyl, cyclohexadienyl, or a 5- or 6-membered heterocyclic ring containing up to three hetero-atoms slected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen, substituted amino or C.sub.1-6 alkoxy; Q represents acetoxy, carbamoyloxy, heterocyclylthio group, or a nitrogen containing heterocyclic group bonded via nitrogen; R.sup.1 is hydrogen or a C.sub.1-6 alkyl group and R.sup.2 is an optionally substituted 5- or 6-membered heterocyclic group containing one or two heteroatoms; or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form an optionally substituted five- or six-membered heterocyclic group containing one or two nitrogen heteroatoms; a process for the preparation of such compounds and pharmaceutical compositions comprising them.

Abstract: Chromogenic aza-12-crown-4 ethers which can be used for the spectrophotometric determination of lithium ion in aqueous solutions are disclosed. The compounds of the invention are particularly useful for the analysis of Li.sup.30 in the presence of Na.sup.+, a situation common in biological and geological systems. The compounds [e.g., 1-(2-oxy-5-nitrobenzyl)-1-hydro-1-aza-4,7,10-trioxacylclododecane], their methods of manufacture, and methods of utilizing the compounds for the analysis of lithium are disclosed and claimed.

Abstract: Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.

Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.