Abstract: A compound having the formula: ##STR1## wherein R.sub.1 is halogen or a substituted or unsubstituted hydrocarbon group; R.sub.2 R.sub.6 and R.sub.7, which may be the same or different, each represents hydrogen or a substituted or unsubstituted hydrocarbon group, or R.sub.6 and R.sub.7 taken together may represent a hetero group having one or more hetero atoms; R.sub.3 and R.sub.4 which may be the same or different each represents a substituted or unsubstituted hydrocarbon group; or R.sub.3 and R.sub.4 taken together may represent an alkylene group or a hetero group having one or more hetero atoms and R.sub.5 is hydrogen, a substituted or unsubstituted hydrocarbon group, halogen or a free or protected hydroxy group, or a pharmaceutically acceptable salt thereof. The compounds have antiaggregating properties.

Abstract: This invention provides a method of inhibiting aromatase and treating estrogen-dependent diseases in mammals by administering certain azole derivatives. Certain azole derivatives and their pharmaceutical formulations are also provided.

Abstract: Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

Abstract: New 1,2,4-triazolo-carbamates of general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the specification, are acetylcholinesterase inhibitors and may be used as drugs for the treatment of senile dementia.

Abstract: Compounds of formula (I): ##STR1## [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R.sup.1 and R.sup.2 are the same or different and each represents an oxygen atom or a group of formula .dbd.N--OR.sup.3 (wherein R.sup.3 represents a hydrogen atom or an alkyl group)], the free hydroxy-carboxylic acids corresponding thereto and salts and esters of said acids may be prepared by oxidizing and, if necessary, oximating a corresponding ML-236A, ML-236B, MB-530A or MB-530B compound, and these compounds have valuable antihypercholesteraemic activity.

Abstract: Azolylmethyl ketones of the formula ##STR1## in which A is a nitrogen atom or the CH group,R is adamantyl, or the group ##STR2## R.sup.1 is neopentyl, optionally substituted phenoxyethyl or cyanoethyl, R.sup.2 is alkyl,R.sup.3 is alkyl or halogen,n is 3, 4, 5, 6 or 7, andm is 1, 2, or 3,are useful as intermediates in making fungicidally active compounds of the formula ##STR3## .

Abstract: Halogenated triazolylvinyl keto derivatives and carbinol derivatives of the general formula ##STR1## in which A represents a keto group or a CH(OH) grouping,X represents a hydrogen or halogen atom,Y represents a halogen atom,R represents a halogen atom, an alkyl, halogenoalkyl, halogenoalkoxy, alkoxy, alkylthio, halogenoalkylthio, alkylamino, dialkylamino, nitro, cyano, hydroxyl or alkylcarbonyloxy radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical or an optionally substituted benzyloxy radical andn is 0, 1, 2 or 3,and physiologically acceptable acid addition salts and metal salt complexes thereof are outstandingly effective as plant growth regulators and as fungicides. The inventive compounds can be prepared by reacting a triazolylketone with an aldehyde.

Abstract: A substituted azolylvinyl ketone or carbinol of the formula ##STR1## in which R.sup.1 represents optionally substituted cycloalkyl with 3 to 5 carbon atoms, substituted cyclohexyl or the grouping ##STR2## wherein R.sup.3 represents optionally substituted phenyl, alkenyl, alkinyl, cyano or the grouping --Z--R.sup.4,whereinR.sup.4 represents alkyl, halogenoalkyl, optionally substituted phenyl or optionally substituted phenylalkyl andZ represents O, S, SO or SO.sub.2,n represents a number from 0 to 2,R.sup.2 represents alkyl, alkenyl, alkinyl, in each case optionally substituted phenyl or phenylalkyl, or in each case optionally substituted cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, bicycloalkyl or bicycloalkenyl, but R.sup.2 does not represent optionally substituted phenyl at the same time as R.sup.1 represents optionally substituted cycloalkyl with 3 to 5 carbon atoms or substituted cyclohexyl or R.sup.

Abstract: Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CH.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.

Abstract: New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, -- CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.

Abstract: The invention provides a novel process for making novel (4-phenyl-1,3,-dioxan-cis-5-yl)alkenoic acids of the formula I in which Ra and Rb are independently hydrogen, alkenyl, alkyl, halogenoalkyl, pentafluorophenyl, aryl or aryl-(1-4C)alkyl; or Ra and Rb together are polymethylene; Rc is hydroxy or (1-6C)alkanesulphonamido, A is vinylene, n is 1, Y is polymethylene, and benzene ring B bears various optional substituents. The process involves the reaction of an aldehyde of formula II with an ylid to give an erythro-diol of formula III which is then cyclized to the required dioxane derivative of formula I. The invention also provides a novel process for making the aldehydes of formula II from the corresponding lactols of formula IIa, which are themselves obtained with the correct trans-stereochemistry by two selective reductions of a trans-phenylparaconic acid of formula V. The compounds of formula I are useful as therapeutic agents.

Abstract: Leach-resistant antimicrobial fabrics are provided which comprise a non-woven substrate, e.g. cellulose, polyethylene or polypropylene; a non-leachable bioactive amount of a silicone quaternary amine, preferably 3-(trimethoxysilyl)-propyloctadecyl dimethyl ammonium chloride; and an organic titanate, preferably triethanolamine titanium chelate. If alcohol and water repellency are desired properties of the fabric, then the fabric further comprises a fluorocarbon repellent with an optional fluorocarbon extender.

Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

Abstract: New substituted triazolylmethyl tert.-butyl carbinols of the formula ##STR1## in which R represents alkyl, alkenyl, alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl or optionally substituted aralkyl,X represents hydrogen or halogen andY represents halogen,and the acid addition salts and metal salt complexes thereof, a process for the preparation of said novel compounds, their use as plant protection agents and as intermediate products for the synthesis of other plant protection agents.

Abstract: This invention is directed to compounds of the formula ##STR1## wherein X is a thiazine or thiazepine of the formula ##STR2## These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.

Abstract: New substituted triazolylmethyl tert.-butyl ketones of the formula ##STR1## in which R represents alkyl, alkenyl, alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl or optionally substituted aralkyl,X represents hydrogen or halogen andY represents halogen,and the acid addition salts and metal salt complexes thereof, a process for the preparation of said novel compounds, their use as plant protection agents and as intermediate products for the synthesis of other plant protection agents.

Abstract: Mixtures of new dimethyl-tricyclo[5.2.1.0.sup.2,6 ]decane derivatives, notably the primary isomers of the common formula A, whereinR.sup.1 and R.sup.2 mean either methyl group or hydrogen, one of the substituents being a methyl group and the other hydrogen,R.sup.3 and R.sup.4 mean either methyl group or hydrogen, one of the substituents being a methyl group and the other hydrogen, andX indicates the .pi.-system of a C-C double bond or an epoxide system, can advantageously be used as new acent- and flavor materials.The compounds of the common formula A, were prepared by hydrogenation of dimeric methylcyclopentadiene selectively in the norbornane part and when desired by epoxidation of the remaining double bond.

Abstract: Described herein are .alpha.-(1-triazolyl)-keto-derivatives of general formula: ##STR1## wherein R is phenyl or heteroaryl, optionally substituted, alkyl; R.sup.1 is alkoxyl, optionally substituted aryloxy, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxycarbonyl, cyano, optionally substituted phenyl, or, along with R.sup.2, an alkylidene; R.sup.2 is H or, along with R.sup.1, an alkylidene; R.sup.3 is alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, cyano or alkoxyalkylcarbonyl; such compounds being endowed with a high fungicidal activity.

Abstract: A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a lower alkyl group or they may together represent a lower alkylene group so as to form a nitrogen-containing cyclic group with the nitrogen atom to which they attach, R.sub.3 is a cycloalkyl(lower)alkyl group, an oxacycloalkyl(lower)alkyl group or a dioxacycloalkyl(lower)alkyl group and n is an integer of 0 to 2, which is useful as a herbicide.

Abstract: Aryltriazolinones of the formula ##STR1## in which W is oxygen or sulfur; X.sup.1 and X.sup.2 are independently selected from halogen, haloalkyl, and alkyl; R is a three- to eight-membered ring heterocyclic group of one or two, same or different, ring heteroatoms selected from oxygen, sulfur, and nitrogen, or an alkyl radical substituted with said heterocyclic group; R.sup.1 is alkyl, haloalkyl, cyanoalkyl, alkenyl, alkynyl, or a group of the formula -alkyl-Y--R.sup.3 ; R.sup.2 is halogen, alkyl, cyanoalkyl, haloalkyl, arylalkyl, or a group of the formula -alkyl-Y--R.sup.3 ; R.sup.3 is alkyl, alkenyl, or alkynyl; and Y is oxygen or S(O).sub.r in which r is 0 to 2 are disclosed and exemplified.