Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

Abstract: An integrated circuit device includes an insulating body provided with a number of electrically conductive leads and having a surface provided with a red LED aperture, an IR LED aperture and a photodetector aperture. The insulating body also includes an optical isolator optically separating the photodetector aperture from the red LED aperture and the IR LED aperture. A red LED is aligned with the red LED aperture, an IR LED is aligned with the IR LED aperture, and a photodetector is aligned with the photodetector aperture.

Abstract: A body-mountable light sensing device includes a photodiode configured to receive light from a portion of subsurface vasculature and electronics configured to operate the photodiode to measure the received light. The electronics include a photodiode voltage source configured to reverse bias the photodiode, a current mirror, and a sigma-delta modulator configured to generate a digital output related to the received light and having a high resolution while using low power. The digital output could be used to determine a pulse rate or other properties of blood in the portion of subsurface vasculature by detecting absorption of ambient light by blood in the portion of subsurface vasculature. Components of the body-mountable device could be embedded in a polymeric material configured for mounting to a surface of an eye. The digital output and/or related information could be wirelessly communicated by the body-mountable device.

Abstract: A blood sugar level prediction device (10) is for predicting the blood sugar level of a user (30). The blood sugar level prediction device (10) is provided with a pattern selection unit (11) that selects one pattern from a plurality of preset blood sugar level time series variation patterns, based on the blood sugar level of the user (30) at the time of fasting, and a correction processing unit (12) that corrects the selected pattern using a plurality of measured values obtained by executing optical measurement of blood sugar levels over a number of measurement dates, targeting the user (30).

Abstract: A physiological measurement system has a sensor, a processor, a communications link and information elements. The sensor is configured to transmit light having a plurality of wavelengths into a tissue site and to generate a sensor signal responsive to the transmitted light after tissue attenuation. The attenuated light can be used by the system to determine a plurality of physiological measurements. The processor is configured to operate on the sensor signal so as to derive at least one physiological parameter after which of the plurality of physiological measurements the system is configured to or capable of measuring.

Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Abstract: A biological signal measuring system includes: a light emitter emitting a first light beam and a second light beam; a light receiver outputting first and second signals in accordance with light intensities of the first and second light beams that have been passed through or reflected from a living tissue of a subject; a first calculating section acquiring a light attenuation of the first light beam based on the first signal and a light attenuation of the second light beam based on the second signal; a second calculating section acquiring a blood-derived light attenuation based on the light attenuation of the first and second light beams; a third calculating section acquiring information relating to a blood oxygen saturation based on a change amount of the blood-derived light attenuation associated with pressurization of the living tissue; and an outputting section outputting the acquired information.

Abstract: Described is a hand-held measuring device 1 for measuring the pH value of wounds at a measuring point, wherein the hand-held measuring device 1 comprises a housing 2, a removable protective case 5 which at least partially encloses the housing 2, and a detection and evaluation unit constructed of at least two elements 6, 7, 9. The evaluation unit is designed to process the measured signals detected by the detection unit. At least one element 7 of the detection and evaluation unit is arranged in or on the housing 2 and at least one element 6, 9 of the detection and evaluation unit is designed as a component of the protective case 5.

Abstract: A detecting device for detecting physiological parameters of a biological tissue includes a light source, at least one light detector, a package, an outer cover, and an optical microstructure. The light source is configured to emit a first beam and a second beam. The package is disposed on the light source and the light detector and is located on the transmission paths of the first and second beams. The outer cover covers the light source, the light detector and the package, and includes a top surface. The optical microstructure is located in the transmission paths of the first and second beams, and is arranged in parallel with the top surface of the outer cover. The optical microstructure includes at least one set of circles of different radii, and is made of a diffractive optical element, a holographic optical element, a computer-generated holographic element, a fresnel lens or a lens grating.

Abstract: An optical sensor includes: a light emitter; a light receiver; a rod-shaped grasping member in which one of the light emitter and the light receiver is disposed, and which is to be grasped by a hand of a subject; and a clamping member which is adapted to clamp a part of the hand of the subject with the grasping member, another one of the light emitter and the light receiver being disposed in the clamping member.

Abstract: A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.

Abstract: A device for applying a sensor to a measurement site on a patient's skin has a wall arrangement defining an applicator volume above the patient's skin. The wall arrangement has a patient's side and a sensor side. At least one gas-permeable membrane separates the applicator volume into a first volume directed to the measuring site at the patient's side of the wall arrangement and a second volume separated from the patient's skin and directed to the sensor side of the wall arrangement.

Abstract: A non-invasive method of detecting anomalous tissue, such as cancerous or injured tissue, in a patient. At least two hemoglobin signal components of hemoglobin levels in at least one segment of tissue of the patient are non-invasively measured over time. Time varying changes of at least a first of the hemoglobin signal components are measured with respect to at least time varying changes of a second of the hemoglobin signal components. A co-varying coordinate system of the time varying changes is generated. Any anomalous tissue in the measured segment of tissue is detected from a signature of the measured segment of tissue in the co-varying coordinate system which differs from a signature of non-anomalous tissue in the co-varying coordinate system. Preferably, five hemoglobin signal components are measured: oxyHb, deoxyHb, total Hb (totalHb=oxyHb+deoxy Hb), Hb oxygen saturation (HbO2Sat=(oxyHb/totalHb)*100), and tissue-hemoglobin oxygen exchange HbO2Exc (deoxyHb?oxyHb).

Abstract: Devices are provided that include a plurality of microneedles that penetrate skin and that receive interstitial fluid from the skin tissue. The microneedles are further configured to direct the received interstitial fluid to nanosensors configured to change an optical property based on interaction with an analyte in the received interstitial fluid, allowing optical detection of the analyte. Direction of the received interstitial fluid to the nanosensors can be facilitated by a pump configured to control the flow rate of the interstitial fluid through the microneedles. Such devices could be configured to detect the analyte independently or in combination with a reader device configured to be periodically mounted to the devices and to detect the analyte. Further, such devices can include delivery systems configured to transdermally deliver a drug or other substance into or through the skin in response to a detected concentration, presence, or other property of the analyte.

Abstract: A sensor for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor has a photonic integrated circuit, e.g. silicon-photonics integrated circuit, for spectrally processing radiation interacting with the sample. A continuous monitoring system can also include such a sensor.

Abstract: According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Abstract: Methods and systems are provided for determining physiological information based on distortion factors and physiological signals. Physiological signals are received by a system. The system may receive or determine a value indicative of oxygen saturation. The distortion factors may be calculated based on the value indicative of oxygen saturation and the physiological signals. The distortion factors may be used to determine physiological information.

Abstract: A bio-information acquiring terminal for acquiring bio-information includes a bath device (300). The bath device (300) is provided with a bio-information measuring unit (320) configured to measure bio-information of a user taking a bath, and a fingerprint authentication unit (303) configured to specify the user. According to the above configuration, it is possible to easily manage daily changes of the health condition of the user in his or her daily life.

Abstract: A system for non-invasively measuring an analyte in a vehicle driver and controlling a vehicle based on a measurement of the analyte. At least one solid-state light source is configured to emit different wavelengths of light. A sample device is configured to introduce the light emitted by the at least one solid-state light source into tissue of the vehicle driver. One or more optical detectors are configured to detect a portion of the light that is not absorbed by the tissue of the vehicle driver. A controller is configured to calculate a measurement of the analyte in the tissue of the vehicle driver based on the light detected by the one or more optical detectors, determine whether the measurement of the analyte in the tissue of the vehicle driver exceeds a pre-determined value, and provide a signal to a device configured to control the vehicle.

Abstract: A device and system for measuring and/or monitoring an analyte present on the skin is provided. The system includes a skin-mountable device that may be attached to an external skin surface and a reader device. The skin-mountable device includes a substrate, a plurality of micro-needles, and nanosensors encapsulated in the micro-needles. The micro-needles are attached to the substrate such that attachment of the substrate to an external skin surface causes to the micro-needles to penetrate into the skin to contact interstitial fluid. The micro-needles can include a sacrificial agent and are configured to become porous on contact with a solvent, e.g., interstitial fluid, which dissolves at least a portion of the sacrificial agent. The nanosensors encapsulated in the micro-needles include a detectable label and are configured to interact with a target analyte present in the interstitial fluid.