Patents Examined by Hsien C Tsai
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Patent number: 11614399Abstract: The present disclosure relates to a system and method for automatic online monitoring of dimethyl sulfide in environment. The method may realize separation of water vapor and the substance to be detected in accordance with the adsorption phase equilibrium principle of substance, thus eliminating the influence of water vapor on detection. The disturbance of other substances in an environmental sample can be eliminated in accordance with the charge or proton transfer principle of molecule ion reaction. Automatic online sampling, preprocessing and sample injection units are configured using valves, numerically controlled motor-driven injectors, flow controllers and a peristaltic pump, so that continuous online detection of DMS in an environmental water sample (e.g., seawater, or lake water) or a gas sample (e.g., atmosphere) can be realized.Type: GrantFiled: November 30, 2020Date of Patent: March 28, 2023Inventors: Jun Sun, Liying Peng, Yu Guo, Dai Jia
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Patent number: 11605532Abstract: The invention relates to a method for, in an ion guide (10), modulating a stream of ions according to a modulation function, wherein the stream of ions includes at least N different ion species, wherein N is at least 1. This ion guide (10) forms an ion guide path, wherein the ions of the stream of ions are conveyed along the ion guide path in a conveying direction to form the stream of ions. The ion guide (10) includes an ion gate (12) arranged at an ion gate position on the ion guide path, wherein the ion gate (12) is adapted to provide an open state for allowing the ions passing the ion gate position when being conveyed along the ion guide path and a closed state for preventing the ions from passing the ion gate position.Type: GrantFiled: May 27, 2021Date of Patent: March 14, 2023Assignee: TOFWERK AGInventors: Stephan Graf, Michael Kamrath, Sebastian Gerber
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Patent number: 11600480Abstract: A mass spectrometry method comprises: receiving a stream of ions at an inlet end of an ion transport device; accumulating a first portion of the ion stream at a first electrical potential well at a first position within the ion transport device between the inlet and outlet ends; creating a generally descending potential profile within the ion transport apparatus between a second position and the outlet end and, simultaneously, creating a second potential well at a third position within the ion transport apparatus, the second position disposed between the first position and the inlet end, the third position disposed between the second position and the inlet end; and transporting the accumulated first portion of the ion stream from the first position to the outlet end under the impetus of the generally descending potential profile and, simultaneously, accumulating a second portion of the ion stream at the second potential well.Type: GrantFiled: September 22, 2020Date of Patent: March 7, 2023Assignee: Thermo Finnigan LLCInventors: Pablo Nieto Ramos, Mikhail V. Ugarov
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Patent number: 11594408Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.Type: GrantFiled: May 16, 2022Date of Patent: February 28, 2023Assignee: Purdue Research FoundationInventor: Robert Graham Cooks
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Patent number: 11581172Abstract: In order to suppress a charge-up in an ion source configured to ionize a component contained in a sample gas, a mass spectrometer according to the present invention is provided with an ion source (3) including: an ionization chamber (30) having an ion ejection opening (301) and internally having a space substantially separated from an outside area; a repeller electrode (31), located within the ionization chamber, for creating an expelling electric field which acts on an ion generated within the ionization chamber to expel the ion through the ion ejection opening to the outside area; and a voltage generator (7) configured to selectively apply, to the repeller electrode, a first voltage for creating the expelling electric field and a second voltage for creating a charge-up-removing electric field, where the second voltage is a positive voltage having a larger absolute value than the first voltage.Type: GrantFiled: September 14, 2021Date of Patent: February 14, 2023Assignee: SHIMADZU CORPORATIONInventor: Yoshihiro Ueno
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Patent number: 11581163Abstract: An ion implanter includes an implantation processing chamber in which an implantation process of irradiating a wafer with an ion beam is performed, a first Faraday cup disposed inside the implantation processing chamber to measure a beam current of the ion beam during a preparation process performed before the implantation process, a second Faraday cup disposed inside the implantation processing chamber to measure a beam current of the ion beam during a calibration process for calibrating a beam current measurement value of the first Faraday cup, and a blockade member for blocking the ion beam directed toward the second Faraday cup, the blockade member being configured so that the ion beam is not incident into the second Faraday cup during the implantation process and the preparation process, and the ion beam is incident into the second Faraday cup during the calibration process.Type: GrantFiled: July 16, 2020Date of Patent: February 14, 2023Assignee: SUMITOMO HEAVY INDUSTRIES ION TECHNOLOGY CO., LTD.Inventors: Hiroyuki Kariya, Yuuji Takahashi
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Patent number: 11562878Abstract: A method for controlling operation of an electron emission source includes acquiring, while varying an emission current of an electron beam, a characteristic between a surface current of a target object at a position on the surface of the target object irradiated with the electron beam, and the emission current, calculating, based on the characteristic, first gradient values each obtained by dividing the surface current of the target object by the emission current, in a predetermined range of the emission current in the characteristic, calculating a second gradient value by dividing a surface current of the target object by an emission current in a state where the electron beam has been adjusted, and adjusting a cathode temperature to make the second gradient value in the state where the electron beam has been adjusted be in the range of the first gradient values in the predetermined range of the emission current.Type: GrantFiled: October 19, 2021Date of Patent: January 24, 2023Assignee: NuFlare Technology, Inc.Inventors: Nobuo Miyamoto, Taku Yamada
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Patent number: 11562879Abstract: An electrostatic beam transfer lens for a multi-beam apparatus that includes a series of multiple, successive electrodes, such that an aperture bore of each electrode is aligned along an electron gun axis and is configured to allow multiple beams to pass therethrough. The first electrode in the series is a cylindrical electrode configured to receive the multiple beams at an entrance plane. The first electrode has a bore length and a bore diameter such that a ratio of bore diameter/bore length<0.3. The shape of the first electrode defines the electrostatic field penetration to the entrance plane of the first electrode to prevent lens focusing fields of the electrostatic beam transfer lens from extending through the first electrode and beyond the entrance plane, thus providing a uniform, flat electric field at the entrance area of the electrostatic transfer lens.Type: GrantFiled: September 15, 2020Date of Patent: January 24, 2023Assignees: NuFlare Technology, Inc., NuFlare Technology America, Inc.Inventor: Victor Katsap
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Patent number: 11551904Abstract: A system and method that allows higher energy implants to be performed, wherein the peak concentration depth is shallower than would otherwise occur is disclosed. The system comprises an ion source, an accelerator, a platen and a platen orientation motor that allows large tilt angles. The system may be capable of performing implants of hydrogen ions at an implant energy of up to 5 MeV. By tilting the workpiece during an implant, the system can be used to perform implants that are typically performed at implant energies that are less than the minimum implant energy allowed by the system. Additionally, the resistivity profile of the workpiece after thermal treatment is similar to that achieved using a lower energy implant. In certain embodiments, the peak concentration depth may be reduced by 3 ?m or more using larger tilt angles.Type: GrantFiled: September 9, 2020Date of Patent: January 10, 2023Assignee: Applied Materials, Inc.Inventors: Venkataramana R. Chavva, KyuHa Shim, Hans Gossmann, Edwin Arevalo, Scott Falk, Rajesh Prasad
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Patent number: 11543385Abstract: An ion mobility filter is disclosed. The present invention relates to but not exclusively a field asymmetric ion spectrometry filter. For example, we describe an ion filter for filtering ions in a gas sample. The ion filter is comprised of a plurality of electrodes, a first ion channel, and a second ion channel. The first ion channel filters ions from a target chemical in the gas sample, defines a gap between a first pair of electrodes in the plurality of electrodes, and has a first ion channel gap width. The second ion channel filters ions from the target chemical in the gas sample, defines a gap between a second pair of electrodes in the plurality of electrodes, and has a second ion channel gap width. The first ion channel gap width is greater than the second ion channel gap width.Type: GrantFiled: October 5, 2018Date of Patent: January 3, 2023Assignees: Owlstone Medical Limited, Owlstone Inc.Inventors: Daniel Melhirst, Jonathan Pearson, Max Allsworth
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Patent number: 11538656Abstract: A sample holder (19) includes a base portion (41), a sample carrying portion (42), a rotation guide portion (43), a cooling stage (46), a connection member (47), a first support portion, and a fixing guide portion (48). The base portion (41) is configured to be fixed to a stage (12), which is configured to be driven to rotate by a stage driving mechanism (13). The rotation guide portion (43) is configured to guide synchronous rotation of the base portion (41) and the sample carrying portion (42). The cooling stage (46) is configured to cool a sample (S). The connection member (47) is configured to be connected to the cooling stage (46). The first support portion is configured to support the base portion (41), which is configured to be driven to rotate by the stage (12).Type: GrantFiled: September 22, 2020Date of Patent: December 27, 2022Assignee: HITACHI HIGH TECH SCIENCE CORPORATIONInventor: Toshiyuki Iwahori
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Patent number: 11527306Abstract: A method of assessing the analytical performance of a biochemical measured using a multi-analyte assay is described. The method includes analytically validating a measurement of the level of a first biochemical in a sample, wherein the first biochemical has been previously analytically validated for three or more analytical validation conditions; measuring the level of a second biochemical in a sample, wherein the second biochemical is structurally or biochemically related to the first biochemical; and comparing validation parameters of the first biochemical with validation parameters of the second biochemical to determine whether the performance of the second biochemical is acceptable based on the comparison results.Type: GrantFiled: October 4, 2018Date of Patent: December 13, 2022Assignee: METABOLON, INC.Inventor: Adam D. Kennedy
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Patent number: 11521823Abstract: A sample attachment device includes a mount, a mounted depression, and a pressure release depression. Liquid and air bubbles can pass the pressure release depression. The mounted depression is on the mount. A cartridge is mounted on the mounted depression. The pressure release depression is in the mounted depression. The pressure release depression is vertically under the cartridge when the cartridge is mounted on the mounted depression.Type: GrantFiled: September 25, 2020Date of Patent: December 6, 2022Assignee: JEOL Ltd.Inventors: Takahisa Kawamura, Hideaki Kimura
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Patent number: 11523489Abstract: Laser plasma optical device comprising a laser system for outputting driving light pulses and signal light pulses, a vacuum target chamber, a gas target generating device for generating gas and forming a required plasma channel target through high voltage capillary discharge ionization (or through laser picosecond pre-pulse ablation) of gas, and a focusing element. The driving light pulse is focused on the generated plasma channel target through the focusing element to generate a density-modulated plasma wake; and after a predetermined delay time T, the signal light pulse is focused onto a leading edge region of a second plasma density cavitation bubble of the plasma wake through the focusing element, so that the frequency of the signal light pulse is red-shifted to generate an ultra-intense near-single-cycle mid-infrared pulse.Type: GrantFiled: February 8, 2021Date of Patent: December 6, 2022Assignee: Shanghai Jiao Tong UniversityInventors: Xinglong Zhu, Suming Weng, Min Chen, Zhengming Sheng, Jie Zhang
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Patent number: 11519889Abstract: A display control unit (52) displays a screen for setting sample information on a display unit (8) for each sample placed in a sample placement section (20), and an input processing unit (53) receives information such as a culture name and seeding date and time information input by an operator via an operation unit (7), and stores the information in a storage unit (55). This file is transferred to a data processing unit (4) and stored in a sample information storage unit (40). After analyzing the respective samples in an LC-MS (3), a quantitative analysis unit (42) performs a quantitative analysis based on the obtained data, associates the analysis result with the sample information, and stores the data in an analysis result storage unit (43). As a result, the sample information and the analysis result of the respective samples in the preprocessing stage are associated with each other.Type: GrantFiled: December 5, 2017Date of Patent: December 6, 2022Assignee: Shimadzu CorporationInventor: Kohei Yamamoto
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Patent number: 11513098Abstract: We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor.Type: GrantFiled: November 29, 2018Date of Patent: November 29, 2022Assignees: Owlstone Medical Limited, Owlstone Inc.Inventors: Max Allsworth, Julian William Few, Isabel Marquez Sillero, Jonathan Pearson
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Patent number: 11515134Abstract: A method for strontium isotope analysis of picogram-level samples using highly sensitive silicotungstic acid emitter is presented by a thermal ionization mass spectrometry. The emitter has merits of extremely high sensitivity, low cost, simple operation, etc. It is an important innovation of the strontium isotope analysis of the picogram-level samples. Compared with a sample consumption of 1-50 ng of conventional emitter, the present invention only needs 30-200 pg to obtain satisfying measurement accuracy. The present invention greatly improves test sensitivity, and has broad application prospects in future.Type: GrantFiled: November 30, 2019Date of Patent: November 29, 2022Assignee: Institute of Geology and Geophysics Chinese Academy of SciencesInventor: Chaofeng Li
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Patent number: 11486866Abstract: When chromatogram data for a target sample have been acquired, a peak position estimator determines an estimated result of the position of the starting and/or ending point of a peak as well as the confidence value representing the reliability of the estimation, using a trained model stored in the trained model storage section. Normally, a plurality of estimated results of the starting point and/or ending point of the peak are acquired for one peak. A peak information correction processor identifies a candidate having the highest confidence as a prime candidate, and superposes a plurality of candidates including the prime candidate, with their respective confidence values, on a displayed chromatogram. An operator referring to the confidence values selects a peak which needs close checking or correction, and corrects the starting point and/or ending point of the selected peak, for example, by selecting and indicating a candidate other than the prime candidate.Type: GrantFiled: November 9, 2017Date of Patent: November 1, 2022Assignee: SHIMADZU CORPORATIONInventors: Takeshi Osoekawa, Yusuke Hida, Yuzi Kanazawa, Shinji Kanazawa, Yohei Yamada, Hiroyuki Yasuda, Akihiro Kunisawa
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Patent number: 11482397Abstract: An ion source is provided. The ion source may include an ion source chamber, and a cathode disposed in the ion source chamber and configured to emit electrons to generate a plasma within the ion source chamber, the cathode comprising a refractory metal, wherein the refractory metal comprises a macrocrystalline structure.Type: GrantFiled: June 3, 2021Date of Patent: October 25, 2022Assignee: Applied Materials, Inc.Inventors: Craig Richard Chaney, Frank Sinclair, Daniel R. Tieger
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Patent number: 11442039Abstract: Provided is a sample support body that includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and a third surface of the conductive layer which is located on a side opposite to the substrate, are formed in the substrate and the conductive layer. At least one of the second surface and the third surface is subjected to surface treatment for providing a difference in an affinity with water between a surface close to the second surface and a surface close to the third surface.Type: GrantFiled: January 8, 2019Date of Patent: September 13, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani