Abstract: A pulse wave detecting device includes: a pressure pulse wave detector which is configured to press a pressing surface in which a pressure detecting element is formed, against a radial artery under a skin of a wrist of a subject, and which is configured to detect a pressure pulse wave from the radial artery; and a housing which accommodates the pressure pulse wave detector in a state where the pressing surface is exposed toward the wrist. The housing is configured so that a compression pressure which is exerted by the housing in an attachment state where the housing is attached to the wrist, and which is applied onto the radial artery is smaller than a compression pressure which is exerted by the pressing surface in the attachment state, and which is applied onto the radial artery.

Abstract: Improvements in ingestible electronics with the capacity to sense physiologic and pathophysiologic states have transformed the standard of care for patients. Yet despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we disclose an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantified its key behaviors in the GI tract by using computational modeling, and validated its functionality in awake and ambulating swine. Our piezoelectric devices can safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for diagnosing and treating motility disorders and for monitoring ingestion in bariatric applications.

Abstract: A method for continuous acoustic signature recognition and classification includes a step of obtaining an audio input signal from a resonant microphone array positioned proximate to a target, the audio input signal having a plurality of channels. The target produces characterizing audio signals depending on a state or condition of the target. A plurality of features is extracted from the audio input signal with a signal processor. The plurality of features is classified to determine the state of the target. An acoustic monitoring system implementing the method is also provided.

Abstract: Sleep performance systems and methods of using the same are disclosed. The sleep performance systems can improve the quality of sleep by making one or more recommendations to the subject for increasing a sleep quality score. The sleep performance systems can have one or more electroencephalography (EEG) electrodes configured to measure a subject's brain activity during sleep. The sleep performance systems can have a processor configured to quantify the quality of the subject's slow-wave sleep by determining one or more sleep performance scores associated with the measured brain activity. The sleep performance systems can recommend and/or activate sleep improvement programs based on various threshold scores.

Abstract: A stretch-measurement probe includes an elongate outer sleeve, expansion feature associated with a distal portion of the outer sleeve, and an elongate inner rod disposed at least partially within the outer sleeve. The expansion feature is configured to allow a longitudinal distance between a proximal end of the outer sleeve and the distal end of the outer sleeve to be varied.

Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, facilitating determination of the oxygen consumption, carbon dioxide production, respiratory exchange ratio, and/or energy expenditure of a mammal.

Abstract: A method for detecting wheeze from an audio respiratory signal comprises capturing the audio respiratory signal from a subject using a microphone. Further, the method comprises recognizing a plurality of breath cycles and a plurality of breath phases from the audio respiratory signal and detecting wheezing from the plurality of breath cycles and the plurality of breath phases. The detecting comprises analyzing a block of interest in the audio respiratory signal, wherein the block of interest comprises a plurality of frames. The detecting further comprises calculating an auto-correlation function (ACF) for each frame in the block and determining a maximum value of the ACF calculated for each frame in the block. Finally, the detecting comprises analyzing the maximum value to detect if wheezing is present in the block.

Abstract: The present specification describes systems and methods that enable the automatic detection, analysis and calculation of various processes and parameters associated with electromyography. The methods of the present specification include the automated modulation of analytical or recording states based on the nature of the signal, optimal reference fiber selection, modulating a trigger level, and determining firing parameters.

Abstract: A blood pressure measurement method includes wrapping a cuff around a site. The cuff includes: a first bladder that swells due to receiving fluid and is arranged at an outer surface of the site that corresponds to a first half surface where an artery is; and a second bladder that swells due to receiving fluid and is arranged at the outer circumferential surface of the measurement site that corresponds to a second half surface opposite to the first half surface. During inflation, the pressure of the second bladder is made larger than the first bladder by supplying more fluid such that the stroke amount by which the second fluid bladder swells is larger in the thickness direction. Then, the two bladders are inflated at equal rates. In the process of inflating, or in the process of deflating at rates equal to each other after inflating, blood pressure is measured.

Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

Abstract: Apparatus for ophthalmic electrophysiological testing, the apparatus comprising: an EER stimulator for providing an electrical stimulus to an eye so as to evoke an electrophysiological response, wherein the EER stimulator comprises a power source; an amplifier for receiving the electrophysiological response and measuring that response, wherein the amplifier is integrated with the EER stimulator; and at least one switch disposed between the power source and the amplifier for isolating the power source from the amplifier when the electrical stimulus is delivered to the eye.

Abstract: Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery.

Abstract: Examples described herein include systems and methods for determining sleep characteristics based on movement data. In one example, a device including at least one accelerometer can be worn by a user during the night. The accelerometer can be configured to detect small motions of the user and provide an output signal. The output signal can be filtered and used to determine whether the user was sleeping during a particular timeframe. The output signal can also be used to determine a sleep characteristic of the sleep, such as light sleep, deep sleep, REM sleep, obstructive apnea, or central apnea.

Abstract: Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

Abstract: The present disclosure provides systems and methods for predicting fluid responsiveness. Embodiments include sensors configured to obtain a high-resolution electrocardiogram signal and a computer system connected to the sensors that detects and processes changes in at least one of length, amplitude, slope, area, depth, and height of at least one of P, Q, R, S, T, and U complex of the electrocardiogram signal caused by the influence of physiological variables on each other to create a prognostic index. The prognostic index of the changes in the electrocardiogram signal may then be used to generate a fluid responsiveness prediction. The fluid responsiveness prediction may then be used to control fluid administration for patients that are receiving anesthesia during surgery or that are critically ill or unresponsive. Disclosed embodiments may also be used as a diagnostic tool for athletes during training, who are undergoing endurance tests, for bike riders, etc.

Abstract: The present invention discloses a Lung condition monitoring device for performing ultrafast detection of humidity level in exhaled air while breathing out and therefrom detect condition of the human lungs in real time. The Lung 5 condition monitoring device comprises a mouthpiece for forcibly exhaling air there through, one or more humidity sensor to measure the variable electrical resistance based on level of adsorption of water molecules thereon of the humidity content of exhaled air and real time monitoring unit operatively connected to said humidity sensor and having correlating means for correlating 10 the change in humidity level and related variation in the electrical resistance due to exhalation to peak flow rate of the exhaled air for monitoring lung condition.

Abstract: A capsule adapted to be introduced into the digestive system and gastrointestinal (GI) tract of a mammal which consists of a capsule shaped container consisting of a wall material capable of being bio compatible with the digestive system and being adapted to protect the electronic and sensor devices contained in the capsule. The capsule contains gas composition sensors operable at several temperature points for a short duration, a temperature sensor, a micro controller, a power source and a wireless transmission device. The capsule wall incorporates gas permeable membranes adjacent said gas sensors. The microprocessor is programmed to receive data signals from the sensors and convert the signals into gas composition and concentration data and temperature data suitable for transmission to an external computing device.

Abstract: The present invention provides a dermal patch for selectively retaining one or more analyte(s) from a body of a subject comprising: a membrane layer (101) for retaining one or more analyte(s) from a body of a subject, with a first and a second side, wherein the first side is adapted to be in fluid communication with the skin of the subject; optionally holding means for securing the membrane layer in place; an adhesive layer (104); and a backing layer; wherein between the backing layer and the membrane layer (101) there is an expandable layer (103) for applying pressure to the membrane layer.

Abstract: The application relates to a chemical monitoring system comprising a skin patch for detecting an analyte in perspiration and a processor adapted to receive parameter data and to return an output indicative of a presence of an analyte in a subject's body based on the parameter data. The skin patch (100) includes a first layer (105) permeable to perspiration; a second layer (110) coupled to the first layer, the second layer being adapted to receive the perspiration; wherein a property of the second layer changes upon receiving the analyte; an electrical detector coupled to the second layer, adapted to detect parameter data indicative of the property of the second layer; and a flexible electronic circuit (140) coupled to the second layer, comprising a readout circuit for reading parameter data from the electronic detector and a transmitter adapted to transmit the parameter data to a processor.

Abstract: Provided is a method for measuring blood glucose levels of a subject with a portable apparatus for noninvasively measuring blood glucose levels including at least one light receiving element for detecting light by using different light integration times, including: (a) switching on an LED for emitting light having wavelength absorbed in or scattered by glucose; (b) measuring a first signal value according to light which is reflected off the surface skin layer of the subject and enters in response to a first light integration time in the situation where the light is radiated; (c) adjusting a second light integration time for measuring light reflected off the inner skin layer of the subject based on the first signal value; (d) measuring a second signal value according to the light which is reflected off the inner skin layer of the subject and enters in response to the adjusted second light integration time; and (e) producing the blood glucose level of the subject by using a third signal value according to light