Patents Examined by Jagadishwar Samala
  • Molecular design toward dual-modality probes for radioisotope-based imaging (PET or SPECT) and MRI
    Patent number: 9463254
    Abstract: In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: October 11, 2016
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Xiankai Sun, Amit Kumar, Zoltan Kovacs
  • Pretargeting kit, method and agents used therein
    Patent number: 9463256
    Abstract: Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: October 11, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Johan Lub, Wolter Ten Hoeve, Raffaella Rossin, Sandra Martina Van Den Bosch, Marc Stefan Robillard
  • Methods for treating conditions of the nail unit
    Patent number: 9446009
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 20, 2016
    Assignee: Hallux, Inc.
    Inventors: Frank Kochinke, Corinne Bright
  • Chelated PSMA inhibitors
    Patent number: 9446157
    Abstract: Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: September 20, 2016
    Assignee: Cancer Targeted Technology LLC
    Inventors: Clifford Berkman, Bea Langton-Webster, Xiaobing Wang
  • Mo compounds as accelerator targets for production of Tc
    Patent number: 9449726
    Abstract: Methods of synthesizing 100Mo2C and 99mTcO4? are disclosed. Methods of 100Mo2C generation involve thermally carburizing 100MoO3. Methods of 99mTcO4 generation involve proton bombardment of 100Mo2C in a cyclotron. Yields of 99mTcO4 can be increased by sintering 100Mo2C prior to bombardment. The methods also include recycling of 100Mo2C to form 100MoO3. SPECT images obtained using 99mTcO4 generated by the disclosed methods are also presented.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 20, 2016
    Assignee: Washington University
    Inventors: Vernal Richards, Suzanne Lapi
  • Macrocycles
    Patent number: 9439984
    Abstract: The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 13, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kenneth N. Raymond, Jide Xu, Tiffany A. Pham
  • Multilayered magnetic micelle compositions and methods for their use
    Patent number: 9439978
    Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: September 13, 2016
    Assignees: University of South Florida, The United States of America as represented by National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Government
    Inventors: Subhra Mohapatra, Chunyan Wang
  • Nitric oxide generating medical devices
    Patent number: 9421223
    Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: August 23, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Thierry Glauser, Stephen D. Pacetti, Paul M. Consigny
  • Bodipy structure fluorescence probes for diverse biological applications
    Patent number: 9423396
    Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 23, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Sung Chan Lee, Nam-Young Kang, Seong Wook Yun, Cheryl Kit Mun Leong, Hyung Ho Ha
  • Family of analogues and NADP+ or NADPH, their preparation and their application in therapeutics
    Patent number: 9409937
    Abstract: A new family of analogues of NADP+ or NADPH, their preparation and their application in therapeutics.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: August 9, 2016
    Assignee: UNIVERSITE PARIS DESCARTES
    Inventors: Anny Slama-Schwok, Jean-Luc Boucher, Yun Xu-Li, Eric Deprez, Etienne Henry, Chantal Dessy, Olivier Feron, Bogdan Tarus
  • Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
    Patent number: 9403794
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: August 2, 2016
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Lei Guo, Di Xu, See-Lok Ho, Chung-Yan Poon, Olivia T. W. Ng, Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong
  • Compositions and methods for multimodal imaging
    Patent number: 9393326
    Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 19, 2016
    Assignee: University Health Network
    Inventors: David Jaffray, Christine Allen, Jinzi Zheng, Raymond Matthew Reilly, Gregory Jason Perkins
  • Methods and compositions for radiohalogen protein labeling
    Patent number: 9393327
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 19, 2016
    Assignee: GENENTECH, INC.
    Inventors: Charles Andrew Boswell, Leslie A Khawli, Jan Marik, Simon Williams
  • N-alkoxyamide conjugates as imaging agents
    Patent number: 9393329
    Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: July 19, 2016
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Thomas D. Harris, Simon P. Robinson, Richard J. Looby, Edward H. Cheesman, Padmaja Yalamanchili, David S. Casebier
  • Luminescent probes for biological labeling and imaging, method for preparing same
    Patent number: 9388202
    Abstract: The present invention relates to organic compounds that are usable as ligands for preparing complexes of lanthanides or of certain transition metals which are water-soluble, to a method for preparing same, and also to the use thereof as a fluorescent probe.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: July 12, 2016
    Assignees: CENTRE NATIONAL DE LA RECHRCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Raymond Ziessel, Mathieu Starck, Alexandra Sutter
  • Radiolabeled prostate specific membrane antigen inhibitors
    Patent number: 9388144
    Abstract: Compounds according to Formula I and Formula II are potent inhibitors of PSMA activity: Pharmaceutical compositions may include a complex of a radionuclide and a compound of Formula I or Formula II.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: July 12, 2016
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. Babich, Craig Zimmerman, John L. Joyal, Genliang Lu
  • Halogenated compounds for cancer imaging and treatment and methods for their use
    Patent number: 9375496
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: June 28, 2016
    Assignees: British Columbia Cancer Agency Branch, The University of British Columbia
    Inventors: Raymond John Andersen, Carmen Adriana Banuelos, Javier Garcia Fernandez, Yusuke Imamura, Jian Kunzhong, Nasrin R. Mawji, Marianne Dorothy Sadar, Jun Wang, Amy (Hsing Chen) Tien
  • Rapid dissolution formulation of a calcium receptor-active compound
    Patent number: 9375405
    Abstract: The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient, wherein the composition has a controlled dissolution profile. The present invention further relates to a method of manufacturing the pharmaceutical composition, as well as a method of treating a disease using the pharmaceutical composition.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: June 28, 2016
    Assignee: Amgen, Inc.
    Inventors: Glen Gary Lawrence, Francisco J. Alvarez, Hung-Ren H. Lin, Tzuchi R. Ju
  • Oxygen sensors
    Patent number: 9375494
    Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 28, 2016
    Assignee: PROFUSA, INC.
    Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William McMillan
  • Methods for treating and diagnosing blinding eye diseases
    Patent number: 9370484
    Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: June 21, 2016
    Assignee: TRANSLATUM MEDICUS INC.
    Inventor: Shelley Romayne Boyd