Patents Examined by Jagadishwar Samala
  • Aryloxyanilide imaging agents
    Patent number: 9186424
    Abstract: The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: November 17, 2015
    Assignee: GE Healthcare Limited
    Inventors: Harry John Wadsworth, Dennis O'Shea
  • Imaging diagnostics by combining contrast agents
    Patent number: 9179882
    Abstract: The present invention relates to the use of a combination of several contrast agents having different properties with respect to imaging representation.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: November 10, 2015
    Assignee: MIVENION GMBH
    Inventor: Ulrike Wiebelitz
  • Non-peptidic quenched fluorescent imaging probes
    Patent number: 9180209
    Abstract: Methods and materials for the imaging of cells and tissues containing active proteases such as cathepsin are disclosed. The present materials include activity based probes that bind to an enzyme and are subsequently cleaved. Cleavage results in covalent attachment of a fluorescent signal to a target protease due to removal of a quenching group which, when present on the probe causes altered or no fluorescence. The probes are non-peptidic, small molecule scaffolds linked to a reactive acyloxymethyl ketone group, a fluorophore and a quencher. The probes are cell permeable and may use, for example, a QSY21 (CAS 304014-13-9) quencher and a cyanine dye. The probes form covalent bonds with the active site of cysteine cathepsins, proteases that are upregulated at the tumor boundaries with normal tissue and at sites of inflammation.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: November 10, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew S. Bogyo, Laura E. Edgington, Martijn Verdoes
  • Use of non-labeled sugars and detection by MRI for assessing tissue perfusion and metabolism
    Patent number: 9180211
    Abstract: A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: November 10, 2015
    Assignee: The Johns Hopkins University
    Inventors: Peter C. Van Zijl, Dmitri Artemov, Kannie Wai Yan Chan, Yoshinori Kato, Michael T. McMahon, Guanshu Liu
  • ?-amyloid plaque imaging agents
    Patent number: 9180212
    Abstract: Various compounds, compositions, and methods for binding to ?-amyloid plaque and norepinephrine transporters are presented. Especially preferred compounds include those with a PET-detectable label.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: November 10, 2015
    Assignee: The Regents of the University of California
    Inventors: Jogeshwar Mukherjee, Min-Liang Pan
  • Bifunctional hydroxy-bisphosphonic acid derivatives
    Patent number: 9173946
    Abstract: The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof, and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: November 3, 2015
    Assignee: ATLANTHERA
    Inventors: Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot
  • CXCR7 antagonists
    Patent number: 9169261
    Abstract: Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: October 27, 2015
    Assignee: ChemoCentryx, Inc.
    Inventors: Junfa Fan, Antoni Krasinski, Christopher W. Lange, Rebecca M. Lui, Jeffrey P. McMahon, Jay P. Powers, Yibin Zeng, Penglie Zhang
  • In vivo imaging method of mood disorders
    Patent number: 9168317
    Abstract: The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the differential diagnosis of said mood disorders and other conditions where there is no abnormal expression of PBR but where the symptoms may be similar to those of said mood disorder.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: October 27, 2015
    Assignee: GE Healthcare Limited
    Inventor: Paul Alexander Jones
  • Method for F-18 FLT synthesis
    Patent number: 9163054
    Abstract: The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 20, 2015
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Li-Yuan Huang, Yen-Hung Tu, Wen-Chin Su, Jenn-Tzong Chen, Ting-Shien Duh, Wuu-Jyh Lin
  • Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
    Patent number: 9156814
    Abstract: The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 13, 2015
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Wanggui Yang, Yi Wong, Olivia T. W. Ng, Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong
  • Imidazolium salts and carbene metal complexes based thereon for use as bioanalytical markers for biomolecules
    Patent number: 9150515
    Abstract: The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilization as bioanalytical tags for biomolecules.
    Type: Grant
    Filed: September 5, 2011
    Date of Patent: October 6, 2015
    Assignee: ERNST-MORITZ-ARNDT-UNIVERSITÄT GREIFSWALD
    Inventor: Olaf Kuehl
  • Process for production of heterodimers of glutamic acid
    Patent number: 9149547
    Abstract: A manufacturing process for the preparation of radiolabeled compounds of formula (I) includes reacting compounds of formula (II) with a source of readionuclide of a halogen in the presence of an oxidant under acidic condition, wherein: *I is 123I, 124I, 125I or 131I; R is lower alkyl, optionally substituted with one or more fluorine atoms; Q is C(O), O, NR?, S, S(O)2, C(O)2, (CH2)p; Y is C(O), O, NR?, S, S(O)2, C(O)2, (CH2)p; R? is H, C(O), S(O)2, C(O)2; Z is H, C1-C4 alkyl, benzyl, substituted benzyl or trialkylsilyl; m is 0, 1, 2, 3, 4 or 5; n is 0, 1, 2, 3, 4, 5 or 6; and p is 0, 1, 2, 3, 4, 5 or 6.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 6, 2015
    Assignee: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
    Inventors: John W. Babich, Craig Zimmerman, Kevin P. Maresca
  • Medical device with intrapore films
    Patent number: 9144634
    Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: September 29, 2015
    Assignee: Covidien LP
    Inventors: Joshua Stopek, Amin Elachchabi, Daniel Broom
  • Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle
    Patent number: 9138492
    Abstract: Provided is a particle which can stably hold a dye in itself even in an aqueous solution such as serum, in order to solve such a problem of a particle containing ICG, which has been conventionally used in a contrast agent or the like, that the ICG is a dye having a hydrophilic functional group and hence the ICG leaks out of the particle in an aqueous solution such as serum. More specifically, provided is a particle including a hydrophobic dye having a cyanine structure, in which the hydrophobic dye is represented by the following chemical formula (1).
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: September 22, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tatsuki Fukui, Fumiko Tomatsu, Kengo Kanazaki, Satoshi Yuasa, Mayuko Kishi, Daisuke Sasaguri
  • High-sensitivity magnetic resonance imaging nano-contrast agent based on an anionic polymer and cationic polymer ion complex, and a production method therefor
    Patent number: 9138491
    Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (?-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a ?-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (?-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (?PGA) and cationic chitosan.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 22, 2015
    Assignees: BIOLEADERS CORPORATION, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee, Hyun Min Kim
  • Conjugates and their uses in molecular imaging
    Patent number: 9138495
    Abstract: The present invention relates to bifunctional compounds, the bifunctional compounds for use in molecular imaging and therapy, methods of molecular imaging using the bifunctional compounds and kits including the bifunctional compounds for use molecular imaging. The bifunctional compounds have a tripodal hydroxypyridinone chelating portion and may be conjugated to a targeting group so that the compounds target specific cells or tissues in a subject.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: September 22, 2015
    Assignee: King's College London
    Inventors: James Russell Ballinger, David Berry, Philip John Blower, Yongmin Ma, Gregory Edgar David Mullen
  • Functionalized naphthalene fluorophores
    Patent number: 9133234
    Abstract: Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 15, 2015
    Inventor: Kay M. Brummond
  • Tc imaging agents and methods of use
    Patent number: 9125955
    Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: September 8, 2015
    Assignee: General Electric Company
    Inventors: Bruce Fletcher Johnson, Randall Lee Carter, Michael James Rishel, Mark Christopher Patrick Darey, Tao Wu, Yang Yang, John Fitzmaurice Valliant, Karin Ann Stephenson
  • Paramagnetic metal-nanodiamond conjugates
    Patent number: 9125942
    Abstract: The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 8, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lisa M. Manus, Daniel J. Mastarone, Dean Ho, Thomas J. Meade
  • Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
    Patent number: 9125937
    Abstract: The present invention relates to the compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4)alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or a group of formula (?): —Y—Z—W—R11??(?) wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a —N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: September 8, 2015
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE D'AUVERGNE CLERMONT 1, LABORATORIES CYCLOPHARMA
    Inventors: Jean-Michel Chezal, Frederic Dolle, Jean-Claude Madelmont, Aurelie Maisonial, Elisabeth Miot-Noirault, Nicole Moins, Janine Papon, Bertrand Kuhnast, Bertrand Tavitian, Raphael Boisgard