Patents Examined by Jagadishwar Samala
  • Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof
    Patent number: 9371360
    Abstract: The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. Because they present multiple copies of the pharmacophore, multivalent ligands can bind to receptors with high avidity and affinity, thereby serving as powerful inhibitors. The modular multivalent scaffolds of the present invention, in one or more embodiments, contains a lysine-based (?-, ?-)dialkyne residue for incorporating two or more antigen binding moieties, such as PSMA binding Lys-Glu urea moieties, exploiting click chemistry and one or more additional lysine residues for subsequent modification with an imaging and/or therapeutic nuclides or a cytotoxic ligands for tumor cell killing.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: June 21, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Gilbert Pomper, Sangeeta Ray, Ronnie C. Mease, Hassan Shallal
  • Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi
    Patent number: 9345793
    Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: May 24, 2016
    Assignee: PIRAMAL IMAGING SA
    Inventors: Markus Berger, Martin Kruger, Jessica Lohrke, Michael Reinhardt, Holger Siebeneicher
  • Ligands for targeting of S1P receptors for in vivo imaging and treatment of diseases
    Patent number: 9345791
    Abstract: The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogs, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: May 24, 2016
    Assignee: Westfaelische Wilhelms-Universitaet Muenster
    Inventors: Guenter Haufe, Bodo Levkau, Michael Schaefers, Stefani Silke Schilson, Petra Keul
  • Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer
    Patent number: 9339564
    Abstract: Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: May 17, 2016
    Assignee: CELLECTAR, INC.
    Inventors: Jamey P. Weichert, Anatoly Pinchuk, Irawati Kandela, Marc Longino, William R. Clarke
  • Activatable fluorogenic compounds and uses thereof as near infrared probes
    Patent number: 9341630
    Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
    Type: Grant
    Filed: September 15, 2013
    Date of Patent: May 17, 2016
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Doron Shabat, Ronit Satchi-Fainaro
  • Coated up-conversion nanoparticles
    Patent number: 9333271
    Abstract: The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising ?-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: May 10, 2016
    Assignee: University of Massachusetts
    Inventors: Gang Han, Jie Shen
  • In vivo imaging method for cancer
    Patent number: 9314541
    Abstract: The present invention provides a method useful in the diagnosis and monitoring of cancer wherein there is an abnormal expression of PBR. The method of the invention is particularly useful in evaluating the severity of the cancer, e.g. PBR expression correlates with cell proliferation rates, metastatic potential, tumor aggressiveness, malignancy progression. The method of the invention can therefore be applied in the determination of likely disease progression and in making an associated prognosis. Furthermore, the method of the invention can find use in determining the likely success of certain therapeutic approaches, or in the evaluation of the efficacy of certain proposed new treatments.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: April 19, 2016
    Assignee: GE Healthcare Limited
    Inventor: Paul Alexander Jones
  • Photostable AIE luminogens for specific mitochondrial imaging and its method of manufacturing thereof
    Patent number: 9315465
    Abstract: AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: April 19, 2016
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Yuning Hong, Sijie Chen, Wai Tung Leung, Engui Zhao, Haiqin Deng
  • Fluorescent probe for imaging lymph nodes
    Patent number: 9302018
    Abstract: Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: April 5, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Hideki Hayashi, Masanori Fujinami, Taro Toyota, Yutaka Tamura, Akira Aoki, Yutaka Muraki, Kazuki Onoue
  • Bacteriochlorin imides
    Patent number: 9303165
    Abstract: Compound of Formula I: are described, along with compositions containing the same and methods of use thereof.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 5, 2016
    Assignee: North Carolina State University
    Inventors: Jonathan S. Lindsey, Michael Krayer
  • Fe(II) sequestering agents and uses thereof
    Patent number: 9302019
    Abstract: Compounds and uses of the compounds are provided. The compounds can be used as Fe(II) sequestering compounds. For example, these compounds can be used to sequester Fe(II) in cells, organs, vasculature, or tissues. Also, provided are compositions and methods of using the them for sequestering Fe(II) in an individual. The compounds can be used as MRI paraCEST contrast agents.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 5, 2016
    Assignee: The Research Foundation for The State University of New York
    Inventors: Janet R. Morrow, Pavel Tsitovich
  • Folate conjugates of albumin-binding entities
    Patent number: 9295739
    Abstract: The present invention is directed towards new trifunctional folate-conjugates comprising a folate, an albumin binder and a radionuclide-based therapeutic or diagnostic moiety as well as pharmaceutical compositions thereof, their method of production and their use in diagnostic and therapeutic medical applications, such as diagnostic nuclear imaging and radionuclide therapy.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 29, 2016
    Assignee: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Harriet Struthers, Viola Groehn, Simon Mensah Ametamey, Cindy Ramona Fischer
  • Contrast agent for imagining myocardial perfusion
    Patent number: 9295738
    Abstract: Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient using diagnostic imaging. Kits including the compound or precursor compounds linked or not linked to an imaging moiety are also described.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: March 29, 2016
    Assignee: RESPIRATORIUS AB
    Inventor: Martin Johansson
  • Composition comprising silver nanoparticles and extracts of Polygonum Multiforum Thunb and the use thereof
    Patent number: 9295694
    Abstract: The present invention relates to a pharmaceutical composition comprising an effective amount of silver nanoparticles and extracts of Polygonum Multiflorum Thunb, a method for increasing hair growth by administering the pharmaceutical composition locally to a host, and use thereof.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: March 29, 2016
    Assignee: Skylight Technology Limited
    Inventor: Mingfen Tsai
  • Radiolabeled compounds and uses thereof
    Patent number: 9290463
    Abstract: The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 22, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Joseph John Mann, J. S. Dileep Kumar
  • Imaging agents, process for the preparation thereof and pharmaceutical compositions containing same
    Patent number: 9278143
    Abstract: Compounds of formula (I) in which: >R is a linear or branched (C1-C6) alkyl, >L is a spacer group, >A is a diagnostic agent, and >m is equal to 1 or 2.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: March 8, 2016
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Alain Lepape, Stéphanie Lerondel, Guillaume Reveillon, Jean-Marie Delbos, Luc Demuynck, Hubert Grandon, François Lefoulon, Gordon Tucker
  • Compositions and methods related to calcitriol
    Patent number: 9271994
    Abstract: Contemplated compositions and methods are drawn to use of various boron-containing compounds to temporarily and transiently increase endogenous blood calcitriol concentration. The boron-containing compound is preferably a carbohydrate-boron complex having sufficient stability to achieve measurable quantities of the complex in blood upon oral administration of the complex.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 1, 2016
    Assignee: VDF Futureceuticals, Inc.
    Inventor: Zbigniew Pietrzkowski
  • Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
    Patent number: 9272055
    Abstract: The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to ?-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: March 1, 2016
    Assignee: The Regents of the University of California
    Inventor: Massoud Akhtari
  • Compounds, probes, and methods of synthesis and methods of imaging COX-2-associated diseases
    Patent number: 9266847
    Abstract: Embodiments of the present disclosure provide for a compound, methods of making a compound, a probe, methods of making a probe, pharmaceutical compositions including a probe or a compound, methods of using a probe, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a disease (e.g., cancer, diseases caused by inflammation (e.g., arthritis, cardiovascular disease, and the like)), and the like, and/or related biological events using a probe, kit for imaging, diagnosing, localizing, monitoring, and/or assessing a disease, and/or related biological events, using a probe, and the like.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: February 23, 2016
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Wellington Pham, Donald D. Nolting, John C. Gore
  • N-alkoxyamide conjugates as imaging agents
    Patent number: 9266846
    Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: February 23, 2016
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Thomas D. Harris, Simon P. Robinson, Richard J. Looby, Edward H. Cheesman, Padmaja Yalamanchili, David S. Casebier