Abstract: A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

Abstract: Provided are systems for measuring an electrocardiogram (ECG) using a wearable device. An example system includes the wearable device. The wearable device has a means for recording an electrical signal from a single wrist of a patient. The wearable device also has a means for detecting a pulse of the patient and recording a photoplethysmogram (PPG) signal, via a PPG optical sensor associated with the wearable device. The wearable device further has a means for generating the electrical signal segments being time-locked to the PPG signal by utilizing the PPG signal as a reference signal. Furthermore, the wearable device has a means for summing the electrical signal segments in a given time period and dividing by the number of segments to produce an average ECG waveform.

Abstract: Disclosed herein are devices, systems, methods and platforms for continuously monitoring the health status of a user, for example the cardiac health status. The present disclosure describes systems, methods, devices, software, and platforms for continuously monitoring a user's low-fidelity health-indicator data (for example and without limitation PPG signals, heart rate or blood pressure) from a user-device in combination with corresponding (in time) data related to factors that may impact the health-indicator (“other-factors”) to determine whether a user has normal health as judged by or compared to, for example and not by way of limitation, either (i) a group of individuals impacted by similar other-factors, or (ii) the user him/herself impacted by similar other-factors.

Abstract: The present invention relates to a three-dimensional adhesive device to be attached to the body surface of a mammal comprising a microelectronic sensing system characterized by (a) a three-dimensional adhesive body made of a pressure sensitive adhesive having an upper surface and a bottom surface; (b) a microelectronic system embedded in the body of the pressure sensitive adhesive; (c) one or more cover layer(s) attached to the upper surface; and (d) optionally a release liner releasable attached to the bottom surface of the adhesive device. Suitably the microelectronic system is a microelectronic sensing system capable of sensing physical input such as pressure, vibration, sound, electrical activity (e.g. from muscle activity), tension, blood-flow, moisture, temperature, enzyme activity, bacteria, pH, blood sugar, conductivity, resistance, capacitance, inductance or other chemical, biochemical, biological, mechanical or electrical properties.

Abstract: Disclosed herein is a robotic tele-surgery system for performing laparoscopic surgeries. The system may include: a patient-side unit, a surgeon-side unit, and a controller that may be configured for establishing a master-slave relationship between the surgeon-side unit and the patient-side unit. The patient side unit may include a patient support assembly, at least two passive mounting mechanisms that may be slidably coupled to the patient support assembly and at least two slave robotic arms, coupled with a surgical instrument via a tool adapting mechanism from their distal end, and mounted on an associated passive support assembly from their base end. The surgeon-side unit may including at least two master robotic arms, and an ergonomic adjustment mechanism that may be configured for housing and adjusting the position and orientation of the master robotic arms.

Abstract: Light energy is applied externally to a patient's head, neck, or both, to treat the brain and nervous system. The light energy stimulates different neurological pathways, reduces inflammation, stimulates mitochondria function in the brain, and increases HRV. The light is applied to the patient on the skull, near the vagus nerve, or a combination thereof. The treatment can be enhanced by activating the cranial nerves while the light is applied. The wavelengths of the applied light range from ultraviolet to far infrared, and preferably are visible light from about 400-760 nm. In a preferred embodiment the applied light is in the red range and more preferably about of 635 nm±10 nm. The applied light energy is applied with a pulse frequency or frequencies that mimic healthy brain function of alpha, beta, delta, and theta waves such as 8 Hz, 53 Hz, 73 Hz and 101 Hz. The pulse frequencies can be applied singularly, serially, alternately, or simultaneously.

Abstract: A three-dimensional adhesive device to be attached to the body surface of a mammal including a microelectronic sensing system. The system includes (a) a three-dimensional adhesive body made of a pressure sensitive adhesive having an upper surface and a bottom surface; (b) a microelectronic system embedded in the body of the pressure sensitive adhesive; (c) one or more cover layer(s) attached to the upper surface; and (d) optionally a release liner releasably attached to the bottom surface. Suitably the microelectronic system is capable of sensing physical input such as pressure, vibration, sound, electrical activity (e,g. from muscle activity), tension, blood-flow, moisture, temperature, enzyme activity, bacteria, pH, blood sugar, conductivity, resistance, capacitance, inductance or other chemical, biochemical, biological, mechanical or electrical purposes.

Abstract: An electronic device can include a housing defining an aperture and at least partially defining an internal volume of the electronic device, an electromagnetic radiation emitter and an electromagnetic radiation detector disposed in the internal volume, and an optical component disposed in the aperture. The optical component can include a first and second transparent portions disposed above the electromagnetic radiation detector and the electromagnetic radiation emitter, and an opaque portion disposed between the first and second transparent portions. A conductive component can be in electrical communication with the opaque portion and one or more components of the electronic device.

Abstract: An electronic device can include a housing defining an aperture and at least partially defining an internal volume of the electronic device, an electromagnetic radiation emitter and an electromagnetic radiation detector disposed in the internal volume, and an optical component disposed in the aperture. The optical component can include a first and second transparent portions disposed above the electromagnetic radiation detector and the electromagnetic radiation emitter, and an opaque portion disposed between the first and second transparent portions and extending a thickness of the optical component. The first transparent portion, the second transparent portion, and the opaque portion can define a flush exterior surface of the electronic device.

Abstract: Laser assisted cataract surgery methods and devices utilize one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may be applied to the anterior lens capsule to facilitate laser thermal separation of tissue along a treatment beam path on the lens capsule. Relative or absolute reflectance from the eye, and optionally from a surgical contact lens, may be measured to confirm and optionally quantify the presence of the light absorbing agent, before the treatment beam is applied.

Abstract: According to an aspect, there is provided an apparatus for use in detecting malingering by a first subject in a test of physical and/or mental function of the first subject.

Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

Abstract: A system predicts the mental state of a user using a variety of contact or contactless sensors that measure heart rate, breathing or other data of the user. The mental state may be flow, overload, underload, stress, attention, motivation, valence, arousal, etc. While performing a game-playing task the difficulty of the task is adjusted based upon the predicted mental state of the user. A classifier for classifying a mental state is trained using event marking and ground truth data. Computer usage generates event markers. Game playing is used to simulate a mental state. Interruptions of a user are prevented when the user enters a flow, focused, or effortful attention state by classifying that state and indicating physically or electronically that the user should not be interrupted. Interruptions of a user are also prevented when the user enters a mind wandering state by classifying or predicting that state and indicating physically or electronically that the user should not be interrupted.

Abstract: Provided are a method and systems for measuring an electrocardiogram (ECG) using a wearable device. An example system includes the wearable device in a shape of a band worn on a limb (e.g., a wrist) of a patient. The wearable device includes an electrical sensor. The wearable device is operable to record, via the at least one electrical sensor, an electrical signal from the limb of the patient. The wearable device is operable to split the electrical signal into segments based on a reference signal. The reference signal includes an indication of onset times of heart beats. The segments are averaged to derive average ECG data of low signal-to-noise ratio. The wearable device includes an optical sensor operable to measure skin color beneath a pulsating artery of the limb. The reference signal includes a photoplethysmogram (PPG) signal recorded via the optical sensor simultaneously with the electrical signal.

Abstract: Systems and methods are provided for analyzing electrocardiogram (ECG) data of a patient using a substantial amount of ECG data. The systems receive ECG data from a sensing device positioned on a patient such as one or more ECG leads/electrodes that may be integrated in a smart device. The system may include an application that communicates with an ECG platform running on a server(s) that processes and analyzes the ECG data, e.g., using neural networks, to detect and/or predict various abnormalities, conditions and/or descriptors. The system may also determine a confidence score corresponding to the abnormalities, conditions and/or descriptors. The processed ECG data is used to generate a graphic user interface that is communicated from the server(s) to a computer for display in a user-friendly and interactive manner with enhanced accuracy.

Abstract: An intracorporeal pressure shock wave includes an expandable pressure shock wave reflector at the distal end of an intracorporeal catheter to direct shock waves from a shock wave generator within a human or animal blood vessel or body lumen.

Abstract: Systems and methods for assessing a patient's risk of renal dysfunction are described. A system may include sensor circuits to sense physiological signals and processors to generate signal metrics from the physiological signals. The system may generate a primary renal risk indication using a first signal metric, and a secondary renal risk indication using at least a second signal metric. The system may generate a composite renal risk indication and estimate a glomerular filtration rate or a chronic kidney disease stage using at least the primary and secondary risk indications. The composite renal risk indication, which indicative of a degree of renal dysfunction, may be presented to a clinician, or provided to a detector for detecting worsening heart failure.

Abstract: Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter.

Abstract: Certain aspects of the disclosure are directed to an apparatus including a scale and external circuitry. The scale includes a platform, and data-procurement circuitry for collecting signals indicative of the user's identity and cardio-physiological measurements. The scale includes processing circuitry to process data obtained by the data-procurement circuitry, therefrom generate cardio-related physiologic data, and to send user data to the external circuitry. The external circuitry identifies a risk that the user has a condition based on the reference information and the user data provided by the scale and outputs generic information correlating to the condition to the scale that is tailored based on the identified risk.

Abstract: The present disclosure provides a system for femtosecond ophthalmic surgery in which a measuring device and a camera generate data that is processed and used to create an enhanced pictorial representation based on the actual positions of the suction ring and the eye. The pictorial representation may include a graphic relating to ophthalmic surgery, such as for a flap or an incision. The disclosure further provides a method for docking a suction ring in femtosecond laser ophthalmic surgery, which includes observing and generating data relating to the position of the suction ring, generating data relating to a pictorial representation of the suction ring and the eye, processing the data relating to the observed position and the pictorial representation to generate an enhanced pictorial representation, and presenting it during surgery. The pictorial representation may include a graphic relating to ophthalmic surgery, such as for a flap or an incision.