Abstract: A patient monitoring system may be used with catheters to monitor the infusion and drainage of any solution into the human body. The system may be used, for example, with in-dwelling catheters for peritoneal dialysis in end stage renal disease (ESRD) patients, urinary tract catheters, insulin pumps in diabetic patients, feeding tubes and central venous line catheters. The patient monitoring system includes one or more fluid pathways for infusing into and/or draining solutions out of the catheter, and one or more sensors to monitor the fluid. The patient monitoring system transmits the patient monitoring data to a database, allowing data storage, processing, and access through graphical user interfaces to patients and providers via device applications or browser-based web access portals.

Abstract: Systems, methods, and apparatuses for reducing error between calculated analyte levels and impractical analyte measurements using practical analyte measurements as reference measurements for calibration. Reducing the error may include converting a practical reference analyte measurement into an estimated impractical analyte level, updating a conversion function using the estimated impractical analyte level, and using the updated conversion function to calculate an analyte level. In some embodiments, the practical reference analyte measurement may be a capillary blood analyte measurement, and the estimated impractical analyte level may be an estimated venous blood analyte level. In some embodiments, the updated conversion function may minimize the error between analyte levels calculated using the updated conversion function and estimated venous blood analyte levels.

Abstract: Systems, methods, and apparatuses that provide alerts based on analyte data and acceleration data. An analyte sensor may generate the analyte data. An accelerometer may generate the acceleration data. A transceiver may convert the analyte data into analyte concentration values. The transceiver may convert the acceleration data into activity information. The transceiver may generate an alert based on the analyte concentration values and activity information. The alert may be communicated to a user by a mobile medical application executed on the transceiver and/or a display device (e.g., smartphone) in communication with the transceiver. The mobile medical application may display (e.g., on a display of the display device) a plot or graph of the analyte concentration values and activity information with respect to time.

Abstract: In an organ of interest in a patient is emplaced a set of sensors designed to monitor parameters of the organ of interest, including at least nicotinamide adenine dinucleotide level and at least one parameter from among the group consisting of tissue blood flow, blood hemoglobin, and tissue reflectance. Substantially continuously, a vitality index of the organ of interest is computed based at least in part on the parameters monitored by the sensors at the organ of interest. Another point of the patient is monitored continuously for a systemic reference, NADH level and at least two parameters from among the group consisting of blood flow (BFS), blood hemoglobin, and tissue reflectance. Substantially continuously, a systemic vitality index is computed from the measured systemic parameters. The vitality index of the organ of interest and systemic vitality index are monitored for a divergence in the temporal trend.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multiple metal protective system including multiple metals incorporated in and/or in close proximity to a surface of the analyte indicator that reduce deterioration of the analyte indicator.

Abstract: This invention is a transvascularly placed steerable guidewire, further including internal steerability and the ability to articulate in a direction at right angles to its longitudinal axis at or near its distal end. The steerable guidewire is generally fabricated from stainless steel and includes an outer tube, an inner tube, hub structures, and a distal articulating region. The steerable guidewire can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature. The steerable guidewire hub can be removed to permit advancement of catheters over its proximal end followed by re-attachment of the hub to permit deflection of the distal end of the steerable guidewire. Removal of the hub can result in a limp guidewire or maintenance of a forced curvature of the distal end of the guidewire.

Abstract: Devices, systems, and methods for patient sensing include a patient sensor having a light diffuser arranged to provide a light field in which photoelectric sensors can be positioned to provide enhanced detection of physiological parameters of the patient. The light diffuser is connected with a sensor baffle to assist in avoiding interference.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: Systems, devices, and methods for tracking one or more physiological metrics (e.g., heart rate, blood oxygen saturation, and the like) of a user are described. For example, one or more light sources and one or more light detectors may be positioned on a wearable device such that light can be emitted towards the user's skin and further such that light reflected back to the wearable device can be measured and used to generate values for the one or more physiological metrics.

Abstract: A biological component estimation apparatus according to an aspect of the present invention includes: a light detector array including a plurality of light detectors; a plurality of light sources disposed on both ends of the light detector array; and a processor configured to calculate a blood vessel alignment index, which indicates a degree of alignment of the biological component estimation apparatus with respect to blood vessels, by using an intensity of a first light that is measured by the plurality of light detectors after the first light is emitted to a user's skin from a first light source disposed on one end of the light detector array among the plurality of light sources, and an intensity of a second light that is measured by the plurality of light detectors after the second light is emitted to the user's skin from a second light source disposed on the other end of the light detector array among the plurality of light sources.

Abstract: A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: The invention relates to a computer-implemented method (10) for determining the blood volume flow (IBI) through a portion (90i, i=1, 2, 3, . . . ) of a blood vessel (88) in an operating region (36) using a fluorophore. A plurality of images (801, 802, 803, 804, . . . ) are provided, which are based on fluorescent light in the form of light having wavelengths lying within a fluorescence spectrum of the fluorophore, and which show the portion (90i) of the blood vessel (88) at different recording times (t1, t2, t3, t4, . . . ). By processing at least one of the provided images (801, 802, 803, 804, . . .

Abstract: A dental probe for determining the vitality of a tooth, comprising a light emitter and a light receiver, wherein the light emitter emits light from an emitter surface adapted to be positioned on a hard dental surface of a tooth, wherein the light receiver collects light incident on a receiver surface adapted to be positioned on a hard dental surface of the tooth so that the optical path of the light emitted from the light emitter passes at least through a portion of the pulp chamber of the tooth. The light receiver includes a light shielding spacer member adjacent to the optical path for establishing and maintaining a distance of at least 50 ?m between the gum line and the optical path at the receiver surface.

Abstract: An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and/or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.

Abstract: A regional oximetry sensor can have a sensor head configured to secure to skin of a user and a stem extending from the sensor head. The sensor head can include an emitter configured to transmit optical radiation into the skin and at least one detector configured to receive the optical radiation after attenuation by blood flow within the skin. The stem can be configured to transmit electrical signals from the sensor head to a cable. A plurality of notches can extend from a perimeter of the sensor head towards an interior thereof. The plurality of notches can form a plurality of independently flexible cutouts in the sensor head configured to allow for movement of at least a portion of the skin of the user underlying the sensor head when the regional oximetry sensor is in use.

Abstract: In one example, the disclosure relates to a catheter system comprising an elongated body defining a lumen. The elongated body comprising a proximal portion and a distal portion. An anchoring member is positioned on the proximal portion of the elongated body. The anchoring member configured to anchor the proximal portion of the elongated body to a patient. The catheter system includes one or more sensors positioned on the elongated body. The one or more sensors are configured to sense a parameter of a fluid within the lumen of the elongated body. The catheter system includes memory positioned on the elongated body, the memory configured to store patient-specific information.

Abstract: A glucose biosensor includes a plurality of optical fibers configured for placement within the ear canal. A first optical fiber emits light into the ear canal. A plurality of other optical fibers capture and transmit the reflected light back to the glucose biosensor. A plurality of photodetectors are configured in the glucose biosensor to detect the reflected light from the plurality of optical fibers. The glucose biosensor processes the detected light from each photodetector to determine a glucose level measurement. In an embodiment, the glucose biosensor also obtains a second glucose level measurement using another method and determines a calibration for the first glucose level measurement using the second glucose level measurement.

Abstract: A biological information measurement device includes a first light emitting portion that emits first light, a second light emitting portion that emits second light, a light receiving portion that receives the first light reflected by an epidermis of a skin, a dermis of the skin, and a subcutaneous layer, and the second light reflected by the epidermis and dermis of the skin, and a processing unit that calculates biological information by removing noise, from a first detection signal output based on the first light received by the light receiving portion, using a second detection signal output based on the second light received by the light receiving portion.

Abstract: A device includes an optical circuit that obtains a first signal at a first wavelength using light reflected from skin tissue of a patient, wherein the first wavelength has a high absorption coefficient for nitric oxide (NO) in blood flow and a second PPG signal at a second wavelength using light reflected from skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for NO in blood flow. A measurement of a level of NO in blood flow is determined using the first PPG signal and the second PPG signal. A health condition is determined using the measurement of the level of NO, such as hyperglycemia or hypoglycemia.