Abstract: Provided is an optical sensor, including a light source configured to emit light; a photodetector array comprising a plurality of photodetectors positioned at different distances from the light source, each photodetector being configured to detect an optical signal returning from an object irradiated by the light emitted by the light source, and to measure a light intensity of the detected optical signal; and a processor configured to determine a correlation coefficient between variables based on the measured light intensity, and to determine a quality of the optical signal based on the determined correlation coefficient, an optical characteristic of the object being determined by selectively using the optical signal of which the quality is an acceptable level or higher.

Abstract: An ocular device is disclosed along with methods for the employment thereof. In one aspect, a device for placement into a lacrimal punctum or conjunctival sac of a person includes one or more sensor materials responsive to one or more components of the chemical composition of the person's tears. Each sensor material is configured to present a tear-based color from a plurality of tear-based colors indicative of a medical condition of the person. In some embodiments, phenylboronic acid could be employed as a sensor material(s). In some embodiments, material(s) emitting radiation when excited by other radiation could be employed as a sensor material. In another aspect, methods for employing the ocular device are disclosed.

Abstract: Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration.

Abstract: A pulse sensing device including main body with at least a pair of sensors, a power source, a power connector, at least one light source electrically coupled to the at least a pair of sensors and a divider configured to separate the power source from the power connector, a casing surrounding the main body, and, an adhesive layer located on a surface of the casing.

Abstract: A vehicle includes a control system for controlling one or more operations of the vehicle. A touchpoint integrated in the vehicle is configured to receive PPG signals reflected from skin of an occupant, wherein the PPG signals are at a plurality of wavelengths. A processing circuit is configured to determine a signal quality of at least one of the PPG signals and generate one or more of: a visible feedback, an audible feedback or a tactile feedback in response the signal quality of the at least one PPG signal. The PPG signals to obtain health information of a user and generate a health message to the control system of the vehicle in response to the health information, wherein the control system controls one or more operations of the vehicle in response to the health message.

Abstract: An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include: a sensor housing, an analyte indicator on at least a portion of the sensor housing, a protective material on at least a portion of the analyte indicator, and a light source in the sensor housing and configured to emit excitation light to analyte indicator. The transceiver may be configured to receive the sensor measurements conveyed by the analyte sensor, infer information about a condition of the environment surrounding the analyte sensor, and calculate an analyte level using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the sensor. The protective material may have a thickness that is thin enough to allow at least some of the excitation light to pass through the protective material and into the environment surrounding the analyte sensor.

Abstract: System, method, and device is presented for generating and processing tissue-monitoring signals. An emitting driver is operable to control, upon receipt of at least one emitted signal, an optical emitter to emit at least one emitted signal. A processor is coupled to the at least one optical emitter and operable to execute instructions to generate the at least one emitted signal. At least one photodetector is operable to detect one or more photons transmitted through tissue and to convert the detected photons into a detected signal. A hardware processing sequence is coupled to the photodetector and processor. The hardware processing sequence is operable to filter and condition the detected signal. The processor is operable to execute instructions to demodulate the at least one emitted signal and the detected signal.

Abstract: A measurement value calculation section calculates the actual measurement value of the hemoglobin concentration of an object to be observed and the actual measurement value of an oxygen saturation thereof on the basis of a plurality of first spectral images. A relative value calculation section calculates the relative value of the hemoglobin concentration and the relative value of the oxygen saturation on the basis of the actual measurement value and the reference value of the hemoglobin concentration and the actual measurement value and the reference value of the oxygen saturation. An image generation section generates a relative value image obtained from the imaging of the relative value of the hemoglobin concentration and/or the relative value of the oxygen saturation, and displays the relative value image on a display unit.

Abstract: Devices, kits, and methods for (a) determining the presence and/or concentration of at least one analyte(s) of interest present in a patient's fluid sample and devices and methods of calibration related thereto, and (b) preventing, mitigating, and/or eliminating biofouling of an indwelling, wearable biosensor are disclosed and/or claimed herein.

Abstract: An implantable optical sensor comprises a photonic integrated circuit comprising a substrate 2 and an optical microstructure 3 integrated with the substrate 2. The optical microstructure is positioned to form an exposed optical interaction area 4 on a part of a surface 5 of the substrate 2. A cover cap 6 is sealed onto a part of the substrate 2 adjacent to the optical interaction area 4 and by wafer-to-wafer bonding technology or another wafer-level hermetic packaging technique. At least one active component 8 is positioned in a sealed cavity 9 which is formed between the surface 5 and the cover cap 6. The substrate 2 comprises at least one optical feedthrough 10, which is an embedded waveguide extending from the sealed cavity 9 to the optical interaction area 4.

Abstract: A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.

Abstract: Biomonitoring systems and methods of loading and releasing the same are disclosed herein. In one embodiment, a biomonitoring system includes a wearable sensor patch and an applicator. The sensor patch has a filament and an electronics subsystem. The sensor patch is configured to detect a parameter of an analyte in fluid of a user when it is adhered to the user's skin and the filament extends into the user's tissue. The applicator includes first and second applicator portions and a spring positioned within an interior of the second application portion between the first and second applicator portions. When the applicator transitions from a loaded mode to a released mode, the spring transitions from a first state of compression to a second, lower state of compression and accelerates the first applicator portion and the wearable sensor patch toward the user's skin such that the filament extends into the user's tissue.

Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.

Abstract: Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.

Abstract: A system, for the transcutaneous measurement of a substance concentration, preferably alcohol, in blood, includes a light source (1); a detector device (15); an optical device (7, 7?), with an inlet (5), an outlet (49) and an exit opening (35); and a contact surface element (37) with a contact surface (41). Measuring radiation emitted by the light source (1) reaches the inlet (5) and exits the exit opening (35), to the contact surface (41). The optical device (7, 7?) focuses measuring radiation at a measuring point (39) at a predefined distance from the contact surface (41). The optical device (7, 7?) is configured such that scattered radiation generated in the measuring point (39) and entering into the exit opening (35) is focused at an outlet point (19) at the outlet (49). The detector device (15) is arranged to detect the scattered radiation focused at the outlet point (19).

Abstract: A device may identify a peak timestamp and a trough timestamp based on a first principal component of photoplethysmography (PPG) data associated with a plurality of wavelength channels. The device may generate a peak absorption spectrum based on the peak timestamp and the PPG data, and may generate a trough absorption spectrum based on the trough timestamp and the PPG data. The device may determine a measured arterial blood spectrum based on the peak absorption spectrum and the trough absorption spectrum. The device may fit the arterial blood spectrum model to the measured arterial blood spectrum to determine a set of values, each value in the set of values corresponding to a variable in a set of variables. The device may calculate an arterial oxygen saturation value based on one or more values of the set of values.

Abstract: An apparatus for non-invasively measuring bio-information is provided. The apparatus includes a plurality of light sources configured to emit light to a first region and a second region of an object, a detector configured to detect a first scattered light signal from the first region and a second scattered light signal from the second region and output a first electrical signal corresponding to the first scattered light signal and a second electrical signal corresponding to the second scattered light signal, and a processor configured to correct the first electrical signal based on the second electrical signal and measure bio-information based on a correction result.

Abstract: Embodiments described herein relate to an implantable device that include an inductor coil, a storage capacitor, active circuitry, and a sensor, but doesn't include an electrochemical cell, and methods for use therewith. During first periods of time, the storage capacitor accumulates and stores energy received via the inductor coil from a non-implanted device. During second periods of time, interleaved with the first periods of time, and during which energy is not received from the non-implanted device, the active circuitry of the implantable device is powered by the energy stored on the storage capacitor and is used to perform at least one of a plurality of predetermined operations of the implantable device, including, e.g., obtaining a sensor measurement from the sensor of the implantable device, transmitting a communication signal including a sensor measurement to the non-implanted device, and/or receiving a communication signal from the non-implanted device.

Abstract: The non-invasive biolipid concentration meter comprises: an irradiator (2) that emits light at a given intensity toward the inside of a living body from outside; a light intensity detector (3) that is disposed at a given distance from a position (21) irradiated with the light from the irradiator (2) and that determines the intensity of light emitted from the living body; a scattering coefficient calculator (4) that calculates the coefficient of light scattering within the living body on the basis of the light intensity determined with the light intensity detector (3); and a lipid concentration calculator (5) that calculates the lipid concentration in the living body on the basis of the coefficient of light scattering.