Patents Examined by Michael G. Wityshyn
  • Patent number: 5628998
    Abstract: A method for improving amoxicillin absorption in mammals such as pigs by administering the amoxicillin to the mammal in combination with one or more of the following plant substances: Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. The plant substance is administered in its natural state, dried, or as an extract.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: May 13, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Seiichi Araki, Mamoru Suzuki, Masatoshi Fujimoto, Tadashi Ueki
  • Patent number: 5627021
    Abstract: The process of the present invention relates to a three dimensional co-culture process.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: May 6, 1997
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, David A. Wolf
  • Patent number: 5624838
    Abstract: A sterilized plant culture medium comprising a dye in an amount which imparts a visible color to the culture medium and which permits seed germination is provided which is useful for attracting children, for observing and studying seed germination, root and shoot formation and whole plant development, and for color-coding plant cultures.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: April 29, 1997
    Assignee: Plant Cell Technology, Inc.
    Inventor: Assaf Z. Guri
  • Patent number: 5624811
    Abstract: Enzyme specific for bilirubin which has a phenol oxidase activity of less than 0.5% and an activity for biliverdin of less than 10%, a broad pH optimum as well as a good thermostability. The enzyme is obtainable from plants such as alfalfa and is suitable for the determination as well as for the degradation of bilirubin in particular in biological liquids.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: April 29, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gunter Lang, Ingo Bohn, Hans-Willi Krell
  • Patent number: 5624671
    Abstract: A pharmaceutical composition or feed, which is useful for immunopotentiating and protecting an animal from infectious diseases, regulating a function of the digestive tract, improving antibiotic absorption, accelerating growth of an animal or improving egg production rate, egg weight, egg quality or eggshell strength of an animal, comprising a pharmaceutically effective amount of a substance selected from the group consisting of Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: April 29, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Seiichi Araki, Mamoru Suzuki, Masatoshi Fujimoto, Tadashi Ueki
  • Patent number: 5622844
    Abstract: A method of producing a mannosyl-cyclodextrin having a mannosyl group bonded to the hydroxyl group of the glucosyl group of a cyclodextrin via an alpha-bond. The method includes treating a liquid containing a cyclodextrin and an alpha-mannosyl compound with an alpha-mannosyl transfer agent.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 22, 1997
    Assignees: Ensuiko Sugar Refining Co., Ltd., Sumio Kitahata
    Inventors: Sumio Kitahata, Koji Hara, Koki Fujita, Nobuhiro Kuwahara, Kyoko Koizumi
  • Patent number: 5622849
    Abstract: A microbial catalase having a catalase activity at 0.degree. C. of 95% or more of its catalase activity at 30.degree. C., when measured at pH 7, and a process for producing the same. The microbial catalase preferably has (1) an operative temperature of 0.degree. to 60.degree. C. and an optimum temperature of 0.degree. to 30.degree. C., when measured within the range of from 0.degree. to 60.degree. C., (2) an optimum pH of 7 to 10, (3) a resistance to 10 mM potassium fluoride, (4) a molecular weight is 65,000.+-.3,000, when measured by SDS polyacrylamide gel electrophoresis, and (5) an isoelectric point is about 4.8, when measured by isoelectric focusing.
    Type: Grant
    Filed: August 21, 1995
    Date of Patent: April 22, 1997
    Assignee: Showa Denko K.K.
    Inventors: Yuichi Fusho, Yoshihiro Yajima
  • Patent number: 5623071
    Abstract: A cyclodextrin having a galactosyl group which is bonded to a 6-hydroxyl group of a glucosyl group of the cyclodextrin via an .alpha.-bond or a .beta.-bond; a cyclodextrin having a mannosyl group which is bonded to a 6-hydroxyl group of the cyclodextrin via an .alpha.-bond.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 22, 1997
    Assignees: Ensuiko Sugar Refining Co., Ltd., Sumio Kitahata
    Inventors: Sumio Kitahata, Koji Hara, Koki Fujita, Nobuhiro Kuwahara, Kyoko Koizumi
  • Patent number: 5620873
    Abstract: A process for preparing a dextrin containing a dietary fiber characterized by dissolving a pyrodextrin in water and causing .alpha.-amylase to act on the solution.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: April 15, 1997
    Assignee: Matsutani Chemical Industries Co., Ltd.
    Inventors: Kazuhiro Ohkuma, Yoshio Hanno, Kazuyuki Inaba, Isao Matsuda, Yasuo Katsuda
  • Patent number: 5620876
    Abstract: Enzymatic hydrolysis and esterification processes for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: April 15, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Brian L. Davis, Paul M. Cino, Laszlo J. Szarka
  • Patent number: 5620872
    Abstract: A cyclodextrin which when added to water produces a haze-free solution is made by the use of starch which contains at least about 90% amylopectin in a two-stage process wherein first a starch hydrolysate is formed by means of an alpha-amylase or an acid and a second subsequent step wherein the cyclodextrin is formed by means of a cyclodextrin-glycosyl-transferase.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 15, 1997
    Assignee: American Maize-Products Company
    Inventors: Wen Shieh, Allan Hedges
  • Patent number: 5618728
    Abstract: Process for the enzymatic separation of phosphinothricin derivatives, which comprises treating a mixture of D- and L-phosphinothricin derivatives of the formulae (I) and (II) ##STR1## with a hydrolytically active enzyme in an aqueous or aqueous-organic medium.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Lothar Willms, Klaus Bartsch
  • Patent number: 5618707
    Abstract: A stereoselective reduction of compound II to compound of formula I ##STR1## which comprises adding ketone substrate II to a culture broth of the Zygosaccharomyces bailii ATCC 38924, incubating the resulting mixture, and isolating a hydroxy compound of formula I, is described. The resulting compound of formula I is useful as an intermediate in the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)propyl]-4(S)-(4-hy droxyphenyl)-2-azetidinone which is a serum cholesterol lowering agent. Also described is a stereoselective reduction of a compound of formula IV to compound of formula III ##STR2## using Schizosaccharomyces octosporus ATCC 2479.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: April 8, 1997
    Assignee: Schering Corporation
    Inventors: Michael J. Homann, Edward Previte
  • Patent number: 5618531
    Abstract: A method for increasing the viability of viable cells which are administered to the brain or spinal cord of a mammalian subject. This method is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain or spinal cord. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 .mu.m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: April 8, 1997
    Assignee: New York University
    Inventor: Bruce D. Cherksey
  • Patent number: 5618705
    Abstract: Anti-inflammatory compounds are useful, for example, in treating arthritis and heart attack patients. Novel oligosaccharides useful in the rapid synthesis of certain anti-inflammatory compounds are disclosed, as is a rapid method of synthesizing the oligosaccharides. Low pH can loosen the acceptor specificity of galactosyltransferase (lactose synthase: EC 2.4.1.22), allowing the rapid synthesis of novel oligosaccharides. The disaccharides cellobiose (.beta.1.fwdarw.4), laminaribiose (.beta.1.fwdarw.3), gentiobiose (.beta.1.fwdarw.6) and maltose (.alpha.1.fwdarw.4) acted as acceptors for lactose synthase under low pH conditions. From these four acceptors, the following four novel trisaccharides were synthesized: Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.3)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.4)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.6)-Glc and Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.alpha.1.fwdarw.4) Glc.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 8, 1997
    Assignee: Board of Supervisors of Louisiana State University Mechanical College
    Inventors: Roger A. Laine, Eunsun Yoon
  • Patent number: 5616479
    Abstract: The invention relates to a fed batch production process for a composition of sophorosides, in which culturing takes place of at least one Candida bombicola or Candida apicola strain and the cultured strain is exposed in a reaction zone to an excess sugar supply and a continuous supply of at least one appropriate substrate at a supply rate to the reaction zone between 0.01 and 4 grams per hour and per liter of initial reaction volume and for a supply time such that the residual concentration of the substrate in the reaction zone is maintained at a value at the most equal to 18 grams per liter of initial reaction volume for the supply time and the composition of sophorosides produced is recovered.
    Type: Grant
    Filed: August 19, 1992
    Date of Patent: April 1, 1997
    Assignee: Institut Francais du Petrole
    Inventors: Remy Marchal, Jeannine Lemal, Caroline Sulzer
  • Patent number: 5614407
    Abstract: Compositions and methods are provided for countering the adverse effects of aging on cells in culture and in vivo in which cells are contacted with the compositions that ameliorate the adverse effects of aging on mammalian cells by slowing or reversing the changes that normally accompanying aging of such cells but do not significantly increase the growth rate or total proliferative capacity of such cells. The compositions contain one or more 6-(substituted amino)purine cytokinins and preferably do not contain ingredients that promote cell division or that induce or potentiate the ability of the 6-(substituted amino) purine cytokinins to promote cell division. Among the preferred applications of the compositions and methods provided herein are the preservation of or restoration of the health of mammalian cells in culture and, by application of the compositions to human skin, the health and youthful appearance of the skin.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: March 25, 1997
    Assignee: Senetek PLC
    Inventor: Suresh I. S. Rattan
  • Patent number: 5614405
    Abstract: This invention is directed to a method of evaluating viral reduction capability of a viral inactivation step in a viral inactivation procedure. The method requires spiking a biological product with a virus more than once during the viral inactivation step so that a virus reduction factor can be calculated.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: March 25, 1997
    Assignee: Immuno Aktiengesellschaft
    Inventors: Johann Eibl, Friedrich Elsinger, Yendra Linnau, Gunther Wober
  • Patent number: 5614188
    Abstract: It is an object of the present invention to provide a soil-borne diseases controlling agent by the use of newly discovered microorganisms having strong antibacterial action. The soil-borne diseases controlling agent according to the present invention is characterized by that the agent comprises microorganisms selected from the group consisting of Bacillus sp. International Deposit Number FERM BP-4375 and Bacillus sp. International Deposit Number FERM BP-4376 as an active ingredient antagonistic against pathogenic Fusarium fungi (Fusarium species).
    Type: Grant
    Filed: June 16, 1995
    Date of Patent: March 25, 1997
    Assignee: Murakashi Lime Industry Co., Ltd.
    Inventors: Teruo Urano, Hiroshi Miyaji, Kazuhiro Maesato
  • Patent number: 5612203
    Abstract: Disclosed is a method for producing saccarides of definite chain length, such as glucose, maltose, malto-oligosaccharides and isomalto-oligosaccharides with a high purity. Saccharides such as starch, dextran and cellulose, and hydrolyzates thereof, are subjected to modification of the anomeric carbon at the reducing end of the molecule without modification of the non-reducing end of the molecule. The modification may be oxidation, for example by bromine to produce a carboxylic acid at the anomeric carbon, or amination, for example by phenylhydrazine to produce an osazone or osone of the saccharide. After modification, the modified saccharide can be adsorbed on an ion exchange resin and then repeatedly cleaved with a suitable enzyme, such as .beta.-amylase, to produce the desired saccharide of definite chain length.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: March 18, 1997
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shigeaki Maruo, Noriyuke Tachikake, Yohji Ezure