Abstract: Embodiments of the present disclosure relate to a circulatory support device with an integrated cannula. In an exemplary embodiment, an apparatus for attachment to a cardiac pump, comprises an adaptor. The adaptor comprises an annular cross section configured to receive the cardiac pump. The annular cross section is secured to the cardiac pump. The adaptor also comprises a plurality of channels arranged around the adapter and a cannula comprising a proximal portion, a distal portion, and an intermediate portion comprising a braided mesh extending between the distal portion and the proximal portion. The proximal portion has a proximal end comprising a plurality of elements arranged through the channels and the distal portion comprises a plurality of wires and a tip element. The plurality of wires extend in a distal direction from the braided mesh to the tip element and are secured to the tip element. And, a coating covers at least a portion of the braided mesh.

Abstract: A sensor circuit that is capable of sensing of neural action potentials is disclosed. The circuit can be designed to minimize power dissipation and total silicon area so that it can be incorporated into a massively parallel sensor array and ultimately implanted in the body (e.g. into the brain) in a safe manner. The circuit can also be designed to be tunable such that it can be optimized in silico prior to fabrication, and can be optimized through the use of controllable current sources after fabrication.

Abstract: An intravascular blood pump comprises a pumping device including an impeller and an electric motor for driving the impeller. A rotor of the electric motor is rotatable about an axis of rotation and coupled to the impeller so as to be able to cause rotation of the impeller. An outer sleeve forms a casing of the pumping device, wherein stator components are fixed inside the outer sleeve by means of a casting compound. In a method of manufacturing the blood pump the stator components are placed on a molding base, including the outer sleeve to thereby form an interspace between the molding base and the outer sleeve in which the stator components are disposed. The casting compound is then injected into the interspace via the molding base to fix the stator components inside the outer sleeve. The outer sleeve preferably comprises a magnetically conductive material to form a yoke of the electric motor.

Abstract: A wearable electronic device comprises a base for mounting a plurality of sensors, where the sensors acquiring physiological data of a user wearing the device. By providing multiple sensors on a single device, additional physiological data, such as pulse transit time, can be provided. To ensure quality data is collected, the device includes a spring mechanism for applying a compressive force on the sensor to force it into the skin of a user.

Abstract: Disclosed are systems and techniques for determining an acoustic biomarker. For example, a precordial sound recording that includes at least a first sound component corresponding to a heart and a second sound component corresponding to a left ventricular assist device (LVAD) can be obtained. At least a portion of the second sound component corresponding to the LVAD can be filtered from the precordial sound recording to yield a filtered precordial sound recording. Based on the filtered precordial sound recording, at least one acoustic biomarker can be determined.

Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

Abstract: A biometric information measurement system and method are disclosed. A biometric information measurement system according to an embodiment of the present invention may comprise an implant device that is inserted into the human body so as to measure biometric information and an external device that transmits a signal to the implantable device while sweeping a frequency.

Abstract: Devices and methods of use for treating atrial arrhythmias. A single-pass lead includes a body portion having at least two electrodes configured to be positioned within or adjacent a right atrium of a heart of a patient, and a distal portion having at least two electrodes configured to be positioned within a blood vessel proximate the left atrium. The lead is configured to operated by an implantable therapy generator programmed to deliver a multi-stage therapy by activating various combinations of at least one electrode of the body portion of the lead and at least one electrode of the distal portion of the lead.

Abstract: An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, where the neural tissue has an activation function. The system may further include a neural modulation generator configured to deliver energy using at least some electrodes to generate a modulation field within the volume of neural tissue. The neural modulation generator may be configured to use a programmed modulation parameter set to generate the modulation field. The programmed modulation parameter set having values selected to control energy delivery using the at least some electrodes to achieve an objective function specific to the activation function of the volume of neural tissue to promote uniformity of a response to the modulation field in the volume of neural tissue along a span of the at least one lead.

Abstract: Some embodiments of percutaneous ventricular assist devices have a two-part design that includes a housing component and a separately deployable rotatable inner catheter component. The housing component can include an expandable pump housing. The inner catheter can include an expandable pump impeller and an associated flexible drive shaft. The drive shaft can be coupled to a motor located external to the patient. The motor can rotate the drive shaft to spin the pump impeller inside of the pump housing, causing blood to be pumped within the patient. In some embodiments, the pump impeller is inflatable or self-expandable. The two-part percutaneous ventricular assist devices with inflatable or self-expandable pump impellers are designed to have very small delivery profiles. Accordingly, various deployment modalities, including radial artery deployment, are practicable using the two-part percutaneous ventricular assist devices described herein.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: A blood pump (10) includes a pump housing (30) having a pump inlet (16) and a pump outlet (18) spaced apart along a longitudinally extending central pump axis (28). The blood pump (10) also includes a rotating assembly (100) comprising an impeller (104). The blood pump (10) further includes partial arc journal bearings (160, 180) that support the rotating assembly (100) for rotation in the housing (30). The rotating assembly (100) is rotatable relative to the housing (30) to pump blood from the pump inlet (16) to the pump outlet (18).

Abstract: An apparatus for monitoring nutrition, especially fermentation in a rumen of a ruminant, is designed to be orally applied to the ruminant and to stay permanently in the rumen. The apparatus includes: a) at least one sensing unit for sensing a characteristic value of dissolved carbon dioxide in the liquor of rumen and/or reticulum; and b) at least one first communication unit for the wireless communication of data with a respective second communication unit outside the ruminant. The sensing unit includes at least one attenuated total reflectance (ATR) sensor.

Abstract: A device, including a housing of a medical device configured to be implanted in a human recipient, the housing having at least one opening on one side of the housing, and a linear feedthrough assembly, wherein the linear feedthrough assembly closes the opening, the housing has a length, a width, and a height, wherein the height is the smallest dimension, and the opening is located in at least about the center of at least one of the length or the width, and the opening faces a direction normal to a plane established by the length and the width.

Abstract: A pacemaker having a motion sensor is configured to select an atrial event sensing vector of a multi-axis motion sensor for sensing atrial systolic events from a motion signal produced by the motion sensor. In some examples, the pacemaker determines a maximum amplitude during a sensing window for each one of multiple vector signals produced by the multi-axis motion sensor. The pacemaker may select the atrial event sensing vector signal from among the vector signals based on the determined maximum amplitudes.

Abstract: Electrocardiogram (ECG) data is compressible at high compression ratios using suitable compressive sensing techniques. Methods of detecting QRS complexes in an ECG signal may comprise receiving compressively-sensed measurements of an ECG signal; constructing an estimate of the ECG signal from the received compressively-sensed measurements, and detecting QRS complexes in the estimate of the ECG signal. QRS complexes may be detected by computing the first-order difference of the estimate of the ECG signal and processing the first-order difference of the estimate of the ECG signal to locate one or more significant natural blocks, each indicating a QRS complex in the ECG signal. QRS complexes may also be detected by using a conventional QRS detection algorithm on the estimate of the ECG signal. Also disclosed are related systems for detecting QRS complexes and for compressively sensing ECG signals.

Abstract: For the purposes of working on eye tissue, an ophthalmological apparatus comprises a laser source that is configured to produce a pulsed laser beam, a focusing optical unit that is configured to focus the pulsed laser beam into the eye tissue, and a scanner system for deflecting the pulsed laser beam onto work target points in the eye tissue. A circuit controls the scanner system in such a way that the scanner system guides the pulsed laser beam into work trajectories that extend next to one another, in order, initially, to produce cut trajectories, separated by remaining tissue bridges, of a tissue cut to be undertaken in an area and in order, thereafter, to guide the pulsed laser beam in the remaining tissue bridges between the cut trajectories in order to complete the tissue cut.

Abstract: The application relates to a pump, in particular blood pump. The pump comprises a drive shaft (3) which runs in an axial direction, a delivery element (6) which is connected to the drive shaft (3) in a distal region of this, and a housing (5) which surrounds the delivery element (6). The delivery element (6) and the housing (5) are designed in a manner such that these automatically unfold after a forced compression. The housing (5) moreover comprises an inlet region (22) with at least one inlet opening (23), a fluid-tight region (20) which surrounds a region of the delivery element (6), and an outlet region (24) with at least one opening (23) for the exit of the pump medium. The delivery element (6) is arranged in a manner such that it projects into the outlet region (24).

Abstract: Apparatus and related methods for assisting tool use includes one or more motors, a wrist support and a shaft coupled to the one or more motors. The shaft includes a coupling to couple to a tool to enable a user resting a hand with the wrist on the wrist support to hold and manipulate the tool with one or more fingers. The apparatus can include a controller configured to: receive position data indicative of a position of an active end of the tool; receive constraint data indicative of one or more regions of space in which the active end should not be positioned; and process the position and constraint data to control the one or more motors to bias the active end out of a region indicated by the constraint data when a position indicated by the position data is within the region indicated by the constraint data.

Abstract: The invention relates to a micromotor (10), the stator of which contains a back iron jacket (18). Said back iron jacket consists of a continuous unslotted sleeve consisting of a metal alloy that contains ferritic iron as the main constituent, up to 30% chromium and preferably aluminium and yttrium oxide. Electric conductivity is reduced by the oxidation of the aluminium. The yttrium oxide performs the same function. The reduced electric conductivity suppresses eddy currents to a great extent. The back iron jacket (18) has a high magnetic conductivity with a small wall thickness, thus increasing the electrical output for a motor with a small diameter.