Abstract: Electrophysiological signals from a graphical representation of an electrophysiology map including a plurality of electrophysiology data points can be sorted by receiving user inputs specifying a number of virtual electrodes for a virtual catheter and defining a pathway of the virtual catheter. A corresponding number of virtual electrodes can be defined on the pathway of the virtual catheter, and one or more electrophysiology data points relevant to electrical activity at the virtual electrodes can be identified, allowing output of a graphical representation of electrophysiological signals corresponding to the identified electrophysiology data points. Relevant electrophysiology data points can be identified by applying one or more relevance criterion, such as a distance criterion, a bipole orientation criterion, a time criterion, and/or a morphology criterion.

Abstract: The present disclosure pertains to a system configured to predict a lucidity level of a subject.

Abstract: A computer program product for controlling a laser-assisted eye treatment, configured to encode a system controller with a routine for planning the eye treatment, invention further relates to a laser-assisted eye treatment system including a laser treatment unit and a system controller, to a method for generating control data for a laser-assisted eye treatment system, to a planning method for a laser-assisted eye treatment and to an eye treatment method using a laser beam for treating a patient's eye. The invention provides systems and methods for a fast laser-assisted eye treatment of a patient's eye which improve the security and minimize the risk of a non-optimal eye treatment and enable sale eye treatment planning and a shortening of the critical phase of the eye treatment. Encoding a system controller by a routine for planning the eye treatment is strictly based on an anatomy of a patient's eye.

Abstract: A wet electrolytic capacitor containing a cathode, fluidic working electrolyte, and planar anode formed from an anodically oxidized sintered porous pellet is provided. The pellet may be formed from a pressed valve metal powder, which in turn, is formed by reacting an oxide of a valve metal compound (e.g., tantalum pentoxide) with a reducing agent that contains a metal having an oxidation state of 2 or more (e.g., magnesium). Through the use of such a powder, the present inventors have discovered that higher capacitance levels can be achieved than previously thought possible for the high voltage capacitors employed in implantable medical devices.

Abstract: A method for delivering energy as a function of degree coupling may utilize an external unit configured for location external to a body of a subject and at least one processor associated with the implant unit and configured for electrical communication with a power source. The method may determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and regulate delivery of power to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna.

Abstract: Provided are the methods and devices to detect and quantify microstructural and functional differences in valve and cardiac disease using heart sounds, specifically for subjects suffering from early stages of valve remodeling. Such methods and devices can be used to detect and quantify microstructural and/or functional differences in, for example, aortic valves of subjects having bicuspid aortic valves and/or suffering from early Calcific Aortic Valve Disease (CAVD).

Abstract: A system for monitoring a fetus in a pregnant woman, and/or the maternal health risk for pregnancies complicated by such as pre-eclampsia and hypertensive disorders is configured to be worn by the pregnant woman, preferably so as to allow monitoring during daily life, e.g. in the form of an adhesive patch. The unit has a sound sensor, e.g. a microphone or accelerometer, to be positioned on the skin of the abdominal area so as to detect a vascular sound from umbilical arteries of the fetus or from the uterine arteries of the pregnant woman. The sound sensor is functionally connected to a processing unit which executes a processing algorithm on the captured vascular sound and extracts a signal parameter accordingly. The processing unit then communicates the signal parameter, e.g. using an audio signal, a visual display or by means of a wired or a wireless data signal.

Abstract: A system for monitoring a patient includes a sensor unit having a housing and sensors disposed in or around the housing; and a base having a shell and configured and arranged to be adhesively attached to skin of the patient. The sensors can be used to monitor physical therapy and rehabilitation of the patient. The sensor unit can provide information to a patient or clinician device to facilitate the monitoring. In some instances, the sensor unit and base are magnetically coupled together. In some instances, the base has an opening so a temperature sensor of the sensor unit can be exposed to the skin of the patient.

Abstract: A method for assessing electrocardiogram signal quality, the method comprising: receiving heart beat analysis data by processing electrocardiogram data acquired from an electrocardiogram monitoring device; extracting position information and width information of a QRS complex in the heart beat analysis data; extracting an RR interval signal between two adjacent QRS complex signals; performing QRS complex signal cancellation processing on the RR interval signal to obtain an RR interval signal for which the QRS complex signal is removed; filtering the processed RR interval signal without the QRS complex signal, and performing envelope calculation on the filtered signal to obtain the average power of a noise signal of the RR interval signal for which the QRS complex signal is removed; obtaining a signal quality evaluation index according to the average power of the noise signal and the power of the QRS complex signal.

Abstract: A system and method for eye treatment. The system and method utilize an electro acupuncture stimulator. The electro acupuncture stimulator includes a positive lead and a negative lead. The system further includes a pair of first needles, a second needle and a diode. The pair of first needles are electrically connected to one of the positive lead and the negative lead. The diode is electrically connected to the other of the positive lead and the negative lead. The second needle is electrically connected to the diode.

Abstract: A gel distribution apparatus can include modules so that each module is connected to a respective sensor of a sensor array included in headgear. Each module can be configured to facilitate the distribution of a gel onto a scalp of a patient to permit deployment of the gel at locations on the head of a patient near the sensor to which the module is adjacently positioned or attached. The modules can each include at least one flange to permit a user to pull the module away from the scalp while also pressing a compressible gel reservoir of the module toward the scalp for directing the gel onto the scalp. The pulling force can help counteract internal pressure generated from compression of the reservoir to expel the gel so that the gel flows along a desired gel flow path without excessive back pressure.

Abstract: Systems and methods are provided for detecting arrhythmias in cardiac activity is provided. The systems and methods include measuring conduction delays between an atria (A) and multiple left ventricular (LV) electrodes to obtain multiple intrinsic A/LV intervals, measuring conduction delays between a right ventricular (RV) and the multiple LV electrodes to obtain multiple intrinsic VV intervals. The systems and methods include calculating a first atrial ventricular (AV) delay based on at least one of the intrinsic A/LV intervals, and calculating a second AV delay based on at least one of the intrinsic VV intervals. The systems and methods include selecting a biventricular (BiV) pacing mode or an LV only pacing mode based on a relation between the first and second AV delays, and delivering a pacing therapy based on the selecting operation.

Abstract: A method of programming an implantable medical device (IMD) configured to provide electrical stimulation via a plurality of stimulation vectors during delivery of the electrical stimulation of a plurality of pulse widths to a neural target. The method may comprise comparing strength-duration curve data for the plurality of stimulation vectors to one another, the strength-duration curve data representing, for respective pulse widths and stimulation vectors, a corresponding stimulation strength that evokes a physiological response associated with the neural target. The method may comprise selecting at least one stimulation vector of the plurality of stimulation vectors based on the comparison of the strength-duration curve data for the plurality of stimulation vectors. The method may comprise programming, in response to the selection, the IMD to deliver the electrical stimulation to the neural target via the selected at least one stimulation vector.

Abstract: A computer implemented method for detecting pocket stability for an implantable cardiac monitor, including under control of one or more processors in the ICM, collecting impedance data over at least one cardiac cycle. The impedance data is processed to separate an impedance waveform that varies over the at least one cardiac cycle in a manner representative of cardiac functionality over the at least one cardiac cycle. A characteristic of interest is analyzed from the impedance waveform over the at least one cardiac cycle. A pocket stability state of the ICM is identified and recorded based on the analyzing operation.

Abstract: Methods are disclosed for determining a prognosis of a test patient following or during a surgical procedure. In some embodiments, the disclosed methods comprise forming a test data vector characterizing concurrent measures of mean arterial pressure (MAP), bispectral index (BIS), and standard minimum alveolar concentration (MAC) of the test patient from sequential time intervals during the surgical procedure. A K-means clustering procedure is performed on the test data vector and a plurality of reference data vectors characterizing concurrent MAP, BIS, and MAC measures for sequential time intervals during surgical procedures from reference patients with known clinical outcome. A prognosis of one or more post-surgical outcomes of the test patient is determined based on the known surgical outcome of reference patients in the cluster including the test data vector.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure.

Abstract: Described herein are methods for treating a subject suffering from or at risk for a condition mediated by an inflammatory cytokine cascade, by electrically or mechanically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.

Abstract: A method of determining responsiveness of a patient wearing a wearable defibrillator configured to deliver therapy to the patient includes sensing an electrocardiogram signal of the patient wearing the wearable defibrillator via a plurality of ECG sensing electrodes, and determining whether a defibrillation treatment should be provided to the patient via at least one treatment electrode. The method includes causing a user interface to provide a patient prompt from the wearable defibrillator responsive to determining that the defibrillation treatment should be provided to the patient. The method includes receiving a first signal indicative of a first patient response within a time interval, receiving a second signal indicative of a second patient response within the time interval, and withholding the defibrillation treatment to the patient via the at least one treatment electrode in response to receiving both the first signal and the second signal within the time interval.

Abstract: Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.