Abstract: A device insertable in the ear canal for substance delivery to and/or extraction from the tympanic cavity is described that includes a stationary body having a distal surface, a proximal surface; a movable body having a distal surface and a proximal surface, disposed within the stationary body and free to move relative to the stationary body in response to a pressure difference created in the ear canal; and at least one piercing element having a distal end and a proximal end, disposed in the movable body.

Abstract: In various embodiments, a device is provided comprising a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being the same or greater than the first pressure. In various embodiments, a method comprising fabricating a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being at or greater than the first pressure, disposing the balloon on an elongate member having a lumen, placing the lumen in fluid communication with an interior volume of the balloon.

Abstract: This present invention provides a delivery device that could be used to delivery discreet small volume of expensive biotechnology treatments to specific areas of the oral cavity, or other tissues. The present invention also provides a method of using the device disclosed herein to deliver biotechnology treatments and/or therapeutic agents to specific areas of the oral cavity, or other tissues. In one embodiment, the treatments and/or therapeutic agents are delivered to the interproximal area between and around the teeth.

Abstract: A robotic catheter device cartridge may include a finger or a slider block generally disposed in a channel and engaged with a steering wire. The steering wire may control movement of a component having the steering wire engaged thereto when the finger or the slider block is linearly driven in a predetermined direction. The cartridge may be a transseptal cartridge having a transseptal needle connected thereto, a catheter cartridge having a catheter connected thereto, or a sheath cartridge having a sheath connected thereto.

Abstract: A head mounted catheter holder assembly is disclosed comprising a head mount assembly and an one or more catheter holders. Said one or more catheter holders comprises a first catheter holder. Said one or more catheter holders attach to said head mount assembly. Said head mount assembly releasably attaches to a head of a user. Said one or more catheter holders releasably hold a one or more catheter tubes.

Abstract: An autoinjector having a body (1010; 2010) receiving a reservoir, a piston, a needle, an actuating 5 sleeve (1011;2011) having a contact end to contact the body of the user and displaceable relative to the body between projected positions, in which the actuating sleeve at least partially projects out of the body receiving a reservoir, and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the body receiving a reservoir. The actuating sleeve is in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector. The actuating sleeve or the body receives a reservoir having a flexible tab adapted to deform laterally relative to the actuating sleeve and/or relative to the body receiving a reservoir when the actuating sleeve is displaced from its first projected position towards its actuation position then from its return actuation position towards its second projected position.

Abstract: Systems for predicting a drug delivery profile as described herein include at least one drug pump and/or a controllable valve that produce a drug flow and dispense at least a first drug. The system also includes at least one carrier fluid pump and/or another controllable valve that produces a carrier fluid flow, a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow, and a fluid path for carrying the mixed flow between the flow junction structure and a delivery point. The system further includes a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow. The model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.

Abstract: The present invention provides a catheter site insertion plug composed of a body that includes an upper surface, a lower surface and a protruding portion extending from the lower surface. The protruding portion of the body forms a frustum having a terminus and defines a passageway extending from an opening at the upper surface to an exit orifice at the terminus of the frustum. The passageway is configured to receive a catheter therethrough. The lower surface may include a second protruding portion in the form of an annular ring around the first protruding portion. The first protruding portion may include an end section that extends radially outward to provide an inflection point generally adjacent the terminus of the frustum. The end section may extend outward to provide at least one radial edge. The present invention also provides a catheter system composed of a flexible catheter and catheter site insertion plug.

Abstract: A non-coring needle for use in accessing an implanted medical device is disclosed. The non-coring needle is configured so as to include a compact bevel face relative to standard non-coring needles. In one embodiment, the non-coring needle comprises a hollow cannula that defines a lumen and terminates at a sharpened distal tip. The cannula includes a proximal portion and a bent distal portion. The distal portion defines a bevel face extending proximally from the distal tip, and the bevel face includes the lumen distal opening. The bevel face defines an open angle of at least about one degree with respect to a longitudinal axis of the proximal portion of the cannula. The bevel face is also laterally offset from the proximal portion of the cannula by an offset distance of no more than about 0.010 inch. A portion of the bevel face is dulled to prevent access port septum coring.

Abstract: Device for medicament delivery with syringe-like usability having a restraining mechanism A device for medicament delivery with syringe-like usability comprising at least one grip, at least one medicament container holder, and at least one plunger rod being substantially rotationally fixed relatively to the grip. The medicament container holder (13) is movable towards the grip in a longitudinal direction of the device, and rotation of at least one rotatable part (40), which is rotatable relatively to the grip and substantially inhibits movement of the plunger rod (20) in a longitudinal direction for dose delivery when in at least one locking position until being rotated, is restrained by at least one restraining member (42) abutting or being connected to the rotatable part (40) and the grip (30) until the medicament container holder is moved towards the grip for interacting with the at least one restraining member.

Abstract: Presented here are techniques for controlling glucose levels of a patient based on predicted time to a target glucose level. One methodology predicts a trajectory of the blood glucose level based on past observations of the blood glucose level, determines a cost expression based on the trajectory, and affects a future command to an infusion pump to affect a cost value according to the cost expression. Another methodology defines a target blood glucose concentration level for the patient, observes a current blood glucose concentration for the patient based on signals received from a blood-glucose sensor, and predicts a duration of time for the patient's blood glucose concentration to reach the target blood glucose concentration level based on the observed current blood glucose concentration.

Abstract: Systems and methods for controlling fluid delivery via a manually administrable medication container to a patient through a fluid delivery pathway are provided. The systems and methods described herein incorporate rules-based clinical decision support logic to drive a flow control valve within a flow pathway based on a determination of whether or not an IV fluid connected to an input port on the pathway is appropriate for patient administration by considering such factors as patient-specific clinical circumstances, current medical orders, and accepted delivery protocols. Related apparatus, systems, methods and articles are also described.

Abstract: A system is provided for testing whether an iontophoretic drug delivery device is in an appropriate state for administering a therapeutic agent into an animal body. An electrical characteristic of at least one electrical path associated with an electrode test point is used to determine whether the iontophoretic device is in an appropriate state. The measured electrical characteristic indicates that the iontophoretic device is in an appropriate state for administering the therapeutic agent into the animal body when the therapeutic agent is properly disposed with respect to the electrodes of the iontophoretic device.

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Abstract: An automatic administration instrument includes a syringe and a partition wall in the syringe which partitions the syringe into different rooms for respectively holding plural kinds of drug solutions or a drug and a drug solution. A partition-wall driver displaces the partition wall and an injection needle is connected to the syringe. A body cap attached to the administration instrument body so as to cover the injection needle. The syringe, the partition wall, and the body cap are configured such that displacing the partition wall dissolves or mixes the drug solutions or the drug and the drug solution in a state that the injection needle is covered by the body cap.

Abstract: A fluid dispensing device includes a container coupled between a bottle and a discharge tube for forcing the fluid to flow through the discharge tube without gravity, a base member is disposed in the container, a housing is engaged in the container and movable toward and away from the base member, a spring biased plug controls the fluid to flow out of the housing, a cap and a casing are attached to the container, a spring biased valve piece is engaged in the casing for engaging with the cap and for controlling the fluid to flow through the cap, a magnetic member is attached to the casing, and a coil is attached to the container to act with and to move the magnetic member in the container.

Abstract: Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.

Abstract: A method for delivering a target volume of fluid to a destination is provided. The method includes delivering a first volume of fluid to the destination in increments each having approximately a first incremental volume, the first volume of fluid being less than the target volume and delivering a second volume of fluid to the destination in increments each having approximately a second incremental volume, the second incremental volume being less than the first incremental volume, such that the sum of the first volume and the second volume is approximately equal to the target volume.

Abstract: An enteral fluid delivery system includes a pump having a motor coupled to a rotor configured to accept a portion of a tubing of a feeding set. The motor drives the rotor, which compresses the tubing to deliver to a patient enteral fluid during a feeding cycle. The system includes a user interface that is operatively connected to a memory that stores a plurality of types of enteral fluids. The user interface enables a user to select at least one type of enteral fluid. The system also includes a processor that is operatively connected to the pump. The processor adjusts the flow rate of the pump to deliver the selected enteral fluid for delivery based on one or more characteristics of the feeding fluid such as the viscosity or the caloric content.

Abstract: A peripheral intravascular catheter assembly comprising a tubular introducer needle and an adapter connected to the proximal end of the light guide. An introducer needle comprises a connection hub and a needle member. The needle member has a lumen, a distal end and a proximal end. The assembly can include a cannula tubing surrounding at least a portion of the needle member, with at least one light source and with an electronic module, configured to power the light source. The light guide has a distal end and a proximal end and extends along the lumen of the needle member. The adapter may be connected to the electronic module to the connection hub of the introducer needle so that light emitted by the light source is capable of entering the light guide, but blood flowing through the lumen of the needle member is prevented from contacting the light source.