Abstract: Connector systems for a fluid container for pharmaceutical solutions are disclosed. The systems include an outer part adapted for insertion into a fluid conducting system and an inner part arranged in said outer part. The outer part includes a tamper-evident closure connected thereto at a predetermined breaking point that can be manually removed. An external side of the inner part abuts an internal side of the outer part. A closure element attached to the inner part prevents a flow of fluid through the inner part. The inner part and the outer part having provided thereon at least one fluid conducting element, such as a furrow, a flute, a depression or a groove. Medical supply systems comprising a bag, such as a dialysis bag, having such systems are also described.

Abstract: A dose setting mechanism that prevents dispensing of a drug when an incorrect cartridge assembly is attached to the dose setting mechanism. Dispense of a drug may be allowed by preventing rotation of a spindle nut of a drug delivery device, and dispense of a drug may be prevented by not preventing rotation of the spindle nut. Preventing dispense of a drug may be accomplished by preventing rotation of the spindle when an incorrect cartridge assembly is inserted. Preventing dispense of a drug may be accomplished by preventing the spindle from applying an axial force on the cartridge when an incorrect cartridge assembly is inserted.

Abstract: A balloon (1) for treating stenosis and the method for obtaining this balloon. The method comprises the steps of: bringing the balloon in the deployed configuration; placing a plurality of stylets (17) that are arranged in the axial direction along the outer wall (10) of the balloon, pushing the stylets towards the balloon core (11) in the radial direction such as to form a plurality of laps (12); laying the laps about the core in the tangential direction such as to lay each lap on an adjacent stylet; removing the stylets such as to form a plurality of cavities (13) comprised between each lap and the balloon core; filling the cavities with the drug.

Abstract: The injection assembly (2) includes a prefilled injection device (3), such as a syringe, provided with a coupling tip (16), for example of the Luer-Lock type, and a protection device (4) comprising a protective portion (23) removably mounted on the coupling tip (16), a supporting portion (30) connected to the protective portion (23), and an injecting element (34) removably mounted on the supporting portion (30) in a storage position. The injecting element (34) comprising an injection needle (35) and a connecting tip (36) fluidly connected to the injection needle (35), the connecting tip (36) being adapted to be mounted on the coupling tip (16) of the injection device (3) in a position of use of the injecting element (34). The injecting element (34) and the supporting portion (30) are arranged in such a way that, in the position of storage of the injecting element (34), the connecting tip (36) is accessible to cooperate with the coupling tip (16).

Abstract: An embeddable micro-needle patch for transdermal drug delivery and method of manufacturing the same are disclosed. The embeddable micro-needle patch for transdermal drug delivery comprises a supporting substrate, on which the surface includes a plurality of extruded supporting shafts; a biodegradable carrier, which is formed of biodegradable polymer material and disposed on the supporting shaft; and drugs, which are encapsulated in the biodegradable carrier. When the embeddable micro-needle patch for transdermal drug delivery is attached to the skin for a predetermined time, the biodegradable carrier is separated from the supporting shafts and embedded into the skin, and the biodegradable carrier may swell and then degrade, so as to release the drugs, which are encapsulated in the biodegradable carrier, at a rate of 1%-99% loaded drug per day into the skin. Accordingly, velocity of releasing the drugs may be regulated, so as to sustain the drug efficacy.

Abstract: Methods, systems, and devices are disclosed for administering a medicament to a patient. In one aspect, a system includes an injection pen device in wireless communication with a mobile communication device. The injection pen device includes a housing including a chamber to encase a cartridge containing medicine, a dose setting and dispensing mechanism to set the mechanism to dispense a particular dose of the medicine from the loaded cartridge, a sensor unit to detect a dispensed dose based on positions and/or movements of the dose setting and dispensing mechanism, and an electronics unit in communication with the sensor unit to process the detected dispensed dose and time data associated with a dispensing event and to wirelessly transmit the dose data to a user's device. The mobile communication device provides a software application to provide the user with health information using the processed dose data.

Abstract: A portable infusion pump can communicate with continuous glucose monitor (CGM) to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Because patient behavior can interfere with the accuracy and efficacy of such closed loop or semi-closed loop therapy, a system can employ various mechanisms for manual temporary suspension of closed-loop therapy when a patient is aware that current or future behavior may inhibit therapy.

Abstract: An autoinjector having a lower body (10) receiving a reservoir, a piston, a needle, a central body (1) fixed to the lower body, an actuating sleeve (11) having a contact end to contact the body of the user and displaceable in the lower body between a projected position, in which the actuating sleeve at least partially projects out of the lower body and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the lower body. The actuating sleeve includes a flexible tab (110) adapted to deform on the one hand radially and on the other hand laterally relative to the central body when the actuating sleeve is displaced from its projected position towards its actuation position then from its return actuation position towards its projected position.

Abstract: An attachment part with a coupling part by means of which coupling part the attachment part can be attached to a dispensing unit. The coupling part has a female cone area, with a continuous inlet opening, and a locking structure arranged around the female cone area. The female cone area can be pushed onto a male cone area of the dispensing unit, in order thereby to connect the attachment part to the dispensing unit. The locking structure serves to secure the attachment part on the dispensing unit. The first coupling part additionally has a rotation element, which is rotatable concentrically about the female cone area and on which the first locking structure is formed. The rotation element has an actuating element, which serves to rotate the rotation element relative to the female cone area.

Abstract: A conduit management device and method for quickly and easily securing a conduit and reducing the risk of conduit disruption is disclosed. A selectively securable cleat is arranged for selective encirclement and securement of at least a portion of a conduit by wrapping the conduit around the cleat. An embodiment is disclosed having an elongate cleat that is fixed to the patient apparatus at a first location of the cleat spaced apart from releasably securable locations proximate first and second ends of the cleat such that the fixation point at the first location forms the fixed base of the cleat.

Abstract: A process to increase hair growth and hair caliber which uses stem cells derived from acellular extracellular matrix, e.g., from urinary bladder and is combined with a nutrient rich medium of autologously harvested platelet rich plasma has been developed. Preferably, a microneedling device is used to induce “micro wounds” aids in the healing process of the hair bearing skin by converting the stem cells in the matrix to progenitor cells.

Abstract: An introducer having a dilator positioned in a sheath is inserted into a first artery and, thereafter, only the dilator tube is drawn out of the first artery and the sheath while the sheath remains in the first artery. A diagnostic instrument having an outer diameter smaller than a maximum outer diameter permitting insertion into the sheath tube is inserted into the second artery, and a stenosis of the second artery is diagnosed. While keeping the sheath indwelling in the first artery, a therapeutic instrument or a catheter permitting the therapeutic instrument to be inserted therein, which therapeutic instrument or catheter has a maximum outer diameter permitting insertion into the sheath tube, is inserted into the second artery, and the second artery is treated.

Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.

Abstract: An infusion pump comprises a tube attachment section configured such that an infusion tube is detachably attachable to the tube attachment section, an access cover configured to close the tube attachment section in an openable manner, and a tube clamp mechanism located within the tube attachment section and configured to clamp and block a portion of the infusion tube. The tube clamp mechanism comprises a base member, a clip clamp member rotatably mounted on the base member, a tube clamp release lever rotatably mounted on the base member, and a tube clamp member rotatably mounted on the base member.

Abstract: Medical devices, perfusion systems, and methods for detecting a pressure within a space in a subject and for perfusion of fluid into a space in a subject. The space may be a fluid-filled space, or a space that is depleted of fluid due to an obstruction to fluid flow into the space. Methods for forming the medical devices.

Abstract: A peritoneal dialysis system includes a base peritoneal dialysis system and a peritoneal dialysis fluid exchange system that operates independently of the base system. The base system includes a first cassette including a first patient line configured to be connected to a patient, and a PD cycler. The PD cycler receives the first cassette, and includes a pump that cooperates with the first cassette to deliver dialysate to and drain dialysate from a peritoneal cavity of the patient via the first patient line. The peritoneal dialysis fluid exchange system includes a second cassette including a second patient line configured to be connected to the patient and a fluid exchange device that receives the second cassette. The fluid exchange device includes a data exchange interface operable to transfer patient treatment data from the peritoneal dialysis fluid exchange system to the base peritoneal dialysis system.

Abstract: A safety needle device comprising a needle hub, an attachment mechanism arranged at the distal end for attaching the safety needle device to a medicament container, and a coaxially arranged needle attachment member. The safety needle device also comprises an injection needle comprising a proximal pointed injection end and a distal pointed non-injection end arranged to penetrate a septum of a medicament container, the injection needle being attached inside the needle hub and extending through the needle attachment member. A rotator arranged to rotate on the hub, the rotator arranged with an annular wall provided with a central passage, such that the needle attachment member of the needle hub extends through a central passage of the rotator. A needle shield surrounds the rotator and slidably arranged with respect to the hub and the rotator.

Abstract: A shielding needle assembly is provided with a hub having a needle cannula with a puncture tip extending from a forward end thereof, and a shield member in telescoping association with the hub. A drive member biases the hub and the shield member away from each other for relative telescopic movement between a first position in which the puncture tip extends from a forward end of the shield member, and a second position in which the puncture tip is encompassed within the shield member. A pivoting lever maintains the hub and the shield member in the first position against the bias of the drive member with the needle cannula exposed for use. The lever is pivotable during contact with a patient's skin surface such as during venipuncture, thereby releasing the hub and the shield member from the first position and permitting the drive member to bias the hub and the shield member toward the second position.

Abstract: A drive mechanism of a drug delivery device is presented having, a piston rod to operably engage with a piston of a cartridge containing a medicament, a first functional component and a second functional component whose position or orientation relative to each other is unambiguously correlated to a predefined axial position of the piston rod, wherein the first and/or the second functional component comprise at least one engaging portion to inseparably and to adhesively engage the first and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached.

Abstract: A method for delivering a target volume of fluid to a destination is provided. The method includes delivering a first volume of fluid to the destination in increments each having approximately a first incremental volume, the first volume of fluid being less than the target volume and delivering a second volume of fluid to the destination in increments each having approximately a second incremental volume, the second incremental volume being less than the first incremental volume, such that the sum of the first volume and the second volume is approximately equal to the target volume.