Abstract: A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

Abstract: A method for monitoring blood pressure includes sensing and storing sympathetic nerve activity data of a patient via a recording lead of an implantable medical device. Changes in sympathetic nerve activity from the nerve activity data are determined. Corresponding changes in blood pressure are determined from the changes in sympathetic nerve activity. An alert signal and/or modification of therapy can be provided.

Abstract: The invention relates to indicator dilution measurements of a central volume (V1) with a first site of injection (S1) upstream of the central volume (V1) a second site of detection (S2) of the diluted indicator downstream of the central volume (V1), wherein a first additional volume (V2) is defined between the first site (S1) and the central volume (V1) and a first additional branch (B2) is defined between the first site (S1) and the central volume (V1) and wherein a second additional volume (V3) is defined between the central volume (V1) and the second site (S2) and a second additional branch (B3) is defined between the central volume (V1) and the second site (S2) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V2, V3) and/or for the first and second additional branches (B2, B3).

Abstract: A method, system and computer program product are provided for evaluating whether an oscillometric signal representative of pressure oscillations in the vasculature of a patient is associated with special conditions that may lead to inadvertently identifying the signal as being indicative of peripheral arterial disease or non-analyzable. In one embodiment, the method includes obtaining an oscillometric signal at a location on an extremity of the patient, determining a ratio using a value associated with a first frequency component of the oscillometric signal and a value associated with a second frequency component of the oscillometric signal, comparing the ratio to a threshold value, associating a first diagnostic class with the oscillometric signal when a first outcome results from comparing the ratio to a threshold value, and associating a second diagnostic class with the oscillometric signal when a second outcome results from comparing the ratio to a threshold value.

Abstract: A device 10 for performing electroencephalography on a patient, the device comprising a sagittal portion 14 comprising: a forehead anchor 44 comprising two forehead anchor arms, a first forehead anchor arm 46 and an opposing second forehead anchor arm 48; a neck anchor 54 comprising two neck anchor arms, a first neck anchor arm 56 and an opposing second neck anchor arm 58; a midsection 52 between the forehead anchor and the neck anchor; and a plurality of imbedded electrodes 20 within the forehead anchor, and the midsection. The device further comprises: a coronal portion 12 comprising a plurality of imbedded electrodes; and electrical connectors 22 for electrically connecting the imbedded electrodes in the sagittal portion and the coronal portion to an electroencephalograph.

Abstract: A method of diagnosing an air leak in a lung compartment of a patient may include: advancing a diagnostic catheter into an airway leading to the lung compartment; inflating an occluding member on the catheter to form a seal with a wall of the airway and thus isolate the lung compartment; measuring air pressure within the lung compartment during multiple breaths, using the diagnostic catheter; displaying the measured air pressure as an air pressure value on a console coupled with the diagnostic catheter; and determining whether an air leak is present in the lung compartment based on the displayed air pressure value during the multiple breaths.

Abstract: Various embodiments of the invention disclosed herein comprise a system of wearable devices that collectively allow for the continuous, non-invasive, measurement and monitoring of blood pressure, without the use of an inflatable cuff. The system incorporates: 1) An optical module, which is comprised of a coherent source of light, a semi-transparent hologram, optics for viewing the interference pattern developed between the illuminated hologram and arterial blood, a Charge-Coupled Device (CCD) array, and processing electronics with Bluetooth capability that facilitates digitization and wireless transmission of the fringe pattern to, 2) a personal digital assistant (PDA) that is worn on a waist belt. The PDA and associated software allow for continuous calculation and monitoring of real-time arterial blood pressure from the digitized fringe patterns received. The system further comprises 3) a personal computer (PC) with wireless capacity and connection to the internet.

Abstract: A blood pressure measurement device is characterized in that the said device is designated to arithmetically apply to the computed blood pressure value a correction value that is in accordance with the difference in atmospheric pressure between the position of the blood pressure transmitting part and the position of the heart of the subject wearing the blood pressure transmitting part as obtained from the sensor signal, on the basis of the internal pressure variation of the blood pressure transmitting part.

Abstract: An electro-encephalography system includes an internal device for implantation below a scalp and above a skull of a patient, and an external device to be worn or carried outside the patient's body. The internal device includes a first electrode for receiving neurological signals originating from the patient's brain and a second electrode for receiving artifacts originating from sources other than the patient's brain. The external device includes a processing unit for receiving data from the internal device, mitigating the effects of the artifacts, and determining a neurological state of the patient. A therapy device is included to provide a therapy to the patient based on the patient's neurological state.

Abstract: Solutions for non-invasively monitoring blood metabolite levels of a patient are disclosed. In one embodiment, the method includes: repeatedly measuring a plurality of electromagnetic impedance readings with a sensor array from: an epidermis layer of a patient and one of a dermis layer or a subcutaneous layer of the patient, until a difference between the readings exceeds a threshold; calculating an impedance value representing the difference using an equivalent circuit model and individual adjustment factor data representative of a physiological characteristic of the patient; and determining a blood metabolite level of the patient from the impedance value and a blood metabolite level algorithm, the blood metabolite level algorithm including blood metabolite level data versus electromagnetic impedance data value correspondence of the patient.

Abstract: Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.

Abstract: An eavesdropping arrangement for acquiring a measured physiological variable of an individual includes a receiver and a communication interface in a housing separate from the receiver. The communication interface is positioned along a communication link between a first sensor, which is configured to measure aortic blood pressure and to provide a signal representing measured aortic blood pressure, and a central monitoring device configured to monitor the measured aortic blood pressure. The communication interface includes a high impedance connection to the communication link that permits the communication interface to eavesdrop on the signal representing measured aortic blood pressure such that information representing measured aortic blood pressure is sent to the receiver while allowing the central monitoring device to receive and use the signal representing measured aortic blood pressure.

Abstract: The present invention relates to a method for evaluating a value representing the mass or the concentration of a substance comprised by a tissue or a bodily fluid of a patient, the method including the steps of a) determining a relation between one or more calculated or measured value(s) reflecting the mass or the concentration and a distribution space of the patient or an approximation thereof, and b) assessing whether the relation fulfills a criterion. The present invention further relates to systems and computer programs for performing this method.

Abstract: An intravascular pressure sensor assembly is disclosed herein that is produced in part using photolithography and DRIE solid-state device production processes. Using DRIE production processes facilitates a number of features that could not be readily incorporated in sensor chips fabricated using mechanical saws. In accordance with a first feature, sensor chips are created with non-rectangular outlines. The sensor chip includes a widened portion that substantially abuts an inner wall of a sensor housing, and a cantilevered portion that is relatively narrow in relation to the widened portion. The non-rectangular outline of the sensor chip is formed using photolithography in combination with DRIE processing. In accordance with another feature, the sensor chip is positioned width-wise in the housing, thereby reducing a required length for the housing.

Abstract: A device for measuring biological information by being worn on a person includes a sensor unit subjected to measure biological information, a device main unit provided with a concavity and subjected to accommodate the sensor unit, and a holding unit supported on one side by the sensor unit and on the other side by the device main unit; wherein the holding unit is elastic and has a space on one side of the concavity to hold the sensor unit so that at least part of the sensor unit extends outside from the device main unit, and wherein the sensor unit is displaced relative to the device main unit by elastic deformation in accordance with an external force applied to the sensor unit.

Abstract: Techniques associated with a wearable device structure with enhanced motion detection by a motion sensor are described, including a band configured to be worn, a nodule coupled to the band, the nodule including a structure configured to enhance detection of movement of an adjacent skin surface, the structure having an articulator configured to rotate in a plurality of planes, and a sensor coupled to the structure and configured to detect rotational motion.

Abstract: The present invention discloses a method to determine the lung clearance index (LCI) or other indices of ventilation inhomogeneity of the lungs by combining two pulmonary gas exchange techniques; Inert gas rebreathing (IGR) is used for rapid wash-in of the inert tracer gas and for accurate determination of the functional residual capacity (FRC) by gas analysis alone. This is followed by multiple-breath wash-out (MBW) for determination of the cumulative expired volume (VCE) required to clear the inert tracer gas from the lungs, and calculation of the LCI as the ratio between VCE and FRC. The advantages of the method are i) significant reduction of required test time, ii) significant reduction of consumed gas mixture for wash-in of tracer gas, iii) potential for further reduction of the use of tracer gas, and iv) more accurate determination of the FRC by gas dilution alone. Furthermore the present invention relates to a corresponding system and computer-readable medium.

Abstract: A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

Abstract: A relatively compact implantable cardiac medical device includes a wireless communications module, which employs a directional antenna and which is adapted to receive input concerning ventricular wall motion. When the cardiac medical device is anchored to a ventricular wall, transmitter elements of the communications modules are only activated for communication during a detected period of reduced ventricular wall motion. The period of reduced ventricular wall motion may be defined as at least one time interval during which an axis of the directional antenna does not rotate out from a baseline orientation by more than 15 degrees. The communication may be conducted with an external programmer-type device, or with another implanted device, for example, located remote from the heart.

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802?, 802? formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.