Patents Examined by Sudhakar Katakam
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Patent number: 11975132Abstract: The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.Type: GrantFiled: February 28, 2019Date of Patent: May 7, 2024Assignee: PLAS-FREE LTDInventors: Abd Alrauf Hijazi, Zeev Dvashi
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Patent number: 11976108Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.Type: GrantFiled: October 15, 2020Date of Patent: May 7, 2024Assignee: James Cook UniversityInventors: Alex Loukas, Andrew Leech, Darren Pickering
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Patent number: 11970551Abstract: The present disclosure relates generally to the field of polypeptide synthesis, and more particularly, to the solution phase synthesis of the Wnt hexapeptide Foxy-5 and protected derivatives and peptide fragments thereof.Type: GrantFiled: March 15, 2023Date of Patent: April 30, 2024Assignee: WNTRESEARCH ABInventor: Dennis Henriksen
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Patent number: 11969512Abstract: A method for producing a protein composition containing a protein (A), a radical scavenger (RS), and at least one hydrogen-bond-formable compound (HC) selected from the group consisting of amino acids, peptides, and proteins other than the protein (A). The method including a sterilization step of radiosterilizing an unsterilized protein composition, wherein the unsterilized protein composition contains the protein (A), the radical scavenger (RS), and the hydrogen-bond-formable compound (HC), the protein (A) contains at least one functional group selected from the group consisting of sulfide, amide, hydroxyl, amino, and carboxyl groups, the hydrogen-bond-formable compound (HC) contains at least one functional group selected from the group consisting of sulfide, amide, hydroxyl, amino, and carboxyl groups, the at least one functional group in the protein (A) is capable of binding to the at least one functional group in the hydrogen-bond-formable compound (HC) via a hydrogen bond.Type: GrantFiled: June 2, 2021Date of Patent: April 30, 2024Assignee: SANYO CHEMICAL INDUSTRIES, LTD.Inventors: Satoshi Somamoto, Shingo Kawabata
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Patent number: 11970432Abstract: The present invention provides a process for preparing 2-methyl-N-(2?-methylbutyl)butanamide of the following formula (1): the process comprising: subjecting an ?-arylethyl-2-methylbutylamine compound of the following general formula (2): wherein Ar represents a substituted or unsubstituted aryl group having 6 to 20 carbon atoms, to N-2-methylbutyrylation to form an N-?-arylethyl-2-methyl-N-(2?-methylbutyl)butanamide compound of the following general formula (3): wherein Ar is as defined above, and removing the ?-arylethyl group of the resulting compound (3) to form 2-methyl-N-(2?-methylbutyl)butanamide (1).Type: GrantFiled: February 28, 2023Date of Patent: April 30, 2024Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takeshi Kinsho, Yusuke Nagae, Shogo Tsukaguchi, Yasuhiko Kutsuwada, Tatsuya Hojo, Takeru Watanabe
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Patent number: 11964025Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.Type: GrantFiled: August 12, 2021Date of Patent: April 23, 2024Assignee: Mersana Therapeutics, Inc.Inventors: Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, Bingfan Du, Dmitry R. Gumerov, Mariya Kozytska, Timothy B. Lowinger, Cheri A. Stevenson, Mao Yin
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Patent number: 11964259Abstract: A catalyst composition for hydrogenating 4,4?-methylenedianiline derivatives is provided. The catalyst composition includes a carrier including aluminum oxide and magnesium oxide, a rhodium-ruthenium active layer loaded on the surface of the carrier, and a solvent including an organic amine. The weight percentage of magnesium oxide in the carrier is between 12% and 30%. A method for preparing 4,4?-methylene bis(cyclohexylamine) derivatives using the catalyst composition is also provided.Type: GrantFiled: December 28, 2020Date of Patent: April 23, 2024Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chao-Huang Chen, Jyun-Da Wu, Tzong-Shyan Lu, Ying-Chieh Lee
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Patent number: 11965015Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.Type: GrantFiled: July 11, 2023Date of Patent: April 23, 2024Assignee: Medikine, Inc.Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
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Patent number: 11958860Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a, g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.Type: GrantFiled: December 7, 2021Date of Patent: April 16, 2024Assignee: Jiangsu Kanion Pharmaceutical Co., Ltd.Inventors: Wei Xiao, Wei Zhang, Yingguang Li, Qingming Guo, Shasha Gu, Hanfei Hu
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Patent number: 11958894Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.Type: GrantFiled: June 23, 2023Date of Patent: April 16, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Jaimie Grapel
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Patent number: 11951158Abstract: The present disclosure provides compositions and therapies that can address both the symptoms and disorders associated with insufficient surfactant production and hyperoxia. In one embodiment, the composition can be formulated for aerosol delivery during ventilation therapy. The composition can comprise one or more of the following: a PPAR gamma agonist, a surfactant peptide, and one or more phospholipids. The compositions are formulated to provide the complementary benefits of reducing the likelihood of developing or the severity of RDS in infants, as well as protecting and promoting lung maturation in a hyperoxic environment.Type: GrantFiled: November 1, 2021Date of Patent: April 9, 2024Assignee: LINDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTERInventors: Virender K. Rehan, John S. Torday, Frans J. Walther, Alan J. Waring, Larry M. Gordon
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Patent number: 11945848Abstract: The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.Type: GrantFiled: August 9, 2022Date of Patent: April 2, 2024Assignee: Omeros CorporationInventors: Peter Garred, Tina Hummelshoj Glue, Mikkel-Ole Skjodt
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Patent number: 11939404Abstract: Cyclized peptides having a crosslinked structure by one or more intramolecular S—S bonds may be prepared by: (1-A) as to a completely protected linear peptide having two or more SH groups as functional groups on the peptide, removing protecting groups of all functional groups other than the protected SH groups in the peptide, (1-B) protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S—S bond, and (2) subjecting the peptide obtained by step (1-A) and step (1-B) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S—S bond in the peptide molecule.Type: GrantFiled: May 13, 2021Date of Patent: March 26, 2024Assignee: AJINOMOTO CO., INC.Inventors: Daisuke Takahashi, Tatsuji Inomata, Yuki Shinohara
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Patent number: 11932588Abstract: The disclosure provides a process for preparing solid tri(C1-C4 alkyl)ammonium dihydrogen phosphates such as triethylammonium dihydrogen phosphate, in high yield, and in a free-flowing particulate form. The solid product advantageously possesses less than about 1500 ppm of aprotic organic solvents, less than about 1500 ppm of C1-C5 alkanols, and less than about 500 ppm of water, as determined by Karl Fischer titration.Type: GrantFiled: November 10, 2022Date of Patent: March 19, 2024Assignee: ENTEGRIS, INC.Inventors: Jonathan W. Dube, Christopher Brown, Keith Hao-Kiet Huynh, Hitendra Patel
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Patent number: 11931398Abstract: Described herein are pharmaceutical compositions comprising terlipressin and therapeutic methods for using them.Type: GrantFiled: June 14, 2019Date of Patent: March 19, 2024Assignee: Ferring B.V.Inventor: Mattias Malm
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Patent number: 11932590Abstract: Provided are an inhibitor for RuO4 gas generation used in a manufacturing process of a semiconductor element, that inhibits a RuO4 gas generated when a semiconductor wafer containing ruthenium and a treatment liquid are brought into contact, and a method for inhibiting the RuO4 gas. Specifically, provided is an inhibitor for RuO4 gas generation for inhibiting a RuO4 gas generated when a semiconductor wafer containing ruthenium and a treatment liquid are brought into contact in semiconductor formation steps, wherein the inhibitor includes an onium salt consisting of an onium ion and a bromine-containing ion. Also provided is a method for inhibiting RuO4 gas generation by adding the inhibitor to a ruthenium treatment liquid or a ruthenium-containing liquid used in semiconductor formation steps.Type: GrantFiled: September 23, 2020Date of Patent: March 19, 2024Assignee: TOKUYAMA CORPORATIONInventors: Tomoaki Sato, Yuki Kikkawa, Takafumi Shimoda, Takayuki Negishi
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Patent number: 11925197Abstract: Improving the balance of beneficial gut microbiota of an animal by providing a composition containing beta-casein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that has a proline at position 67 of the beta-casein amino acid sequence.Type: GrantFiled: September 30, 2016Date of Patent: March 12, 2024Assignee: THE A2 MILK COMPANY LIMITEDInventors: Andrew John Clarke, Catherine Mary Babidge, Jiayi Ni
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Patent number: 11925673Abstract: The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.Type: GrantFiled: September 10, 2021Date of Patent: March 12, 2024Assignee: The Provost, Fellows, Foundation Scholars, & The Other Members of Board, of the College of the HolyInventors: Matthew Campbell, Sarah Doyle, Natalie Hudson, Lucia Celkova
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Patent number: 11926580Abstract: A hydropersulfide precursor compound having the formula (I): formula (I) as defined in the specification. A process for preparing the hydropersulfide precursor, and a method of using the precursor to generate hydropersulfide are also described.Type: GrantFiled: August 30, 2019Date of Patent: March 12, 2024Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: John Pasquale Toscano, Vinayak S. Khodade
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Patent number: 11926574Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.Type: GrantFiled: June 8, 2022Date of Patent: March 12, 2024Assignee: Atai Therapeutics Inc.Inventors: Glenn Short, Robert B. Perni, Benjamin Robert Difrancesco, Tanweer A. Khan