Abstract: The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.
Abstract: Provided is a photo-oxidation reaction of benzylic C—H bonds of an aromatic compound under the catalysis of an acid catalyst. The method aims to synthesize aromatic acids and acetophenones. The acid catalyst is one of Bronsted acids, including one or a mixture of two or more selected from the group consisting of hydrochloric acid, phosphoric acid, sulfuric acid, p-toluenesulfonic acid, methanesulfonic acid, trifluoromethanesulfonic acid, trifluoroacetic acid, and potassium hydrogen sulfate, as well as N-propylsulfonate pyridinium hydrogensulfate, N-butylsulfonate pyridinium hydrogensulfate, N-propylsulfonate pyridinium trifluoromethanesulfonate, N-butylsulfonate pyridinium trifluoromethanesulfonate, N-propylsulfonate pyridinium tetrafluoroborate, and N-butylsulfonate pyridinium tetrafluoroborate. The oxidation reaction is conducted under mild conditions (normal temperature and pressure) using air or oxygen as the oxidant in the presence of recyclable catalyst and solvent.
Type:
Grant
Filed:
January 19, 2022
Date of Patent:
October 3, 2023
Assignee:
NANJING TECH UNIVERSITY
Inventors:
Yufeng Li, Hongjun Zhu, Hongfei Ma, Hongzhong Bu, Jieqing Wu, Jiefan Gu, Jiwei Chen, Haoyue Zhang, Chen Wang
Abstract: Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The Peptides modulate the activity of the transcription factor NF ?B.
Abstract: The present invention provides a method for producing primary amines and secondary amines, the method being characterized by reducing a primary amide or a secondary amide in the presence of a reducing agent and an organic metal halide of a group-2 element.
Abstract: In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identical groups. Also provided herein are compositions for use in the preparation of the secondary amine.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
September 26, 2023
Assignee:
William Marsh Rice University
Inventors:
Padmanabha Venkatesh Kattamuri, Laszlo Kurti
Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst.
Type:
Grant
Filed:
December 28, 2021
Date of Patent:
September 26, 2023
Assignee:
East China University of Science and Technology
Abstract: The present invention relates to compositions comprising daptomycin and at least one amino acid, methods of providing such compositions and the uses thereof.
Type:
Grant
Filed:
August 28, 2018
Date of Patent:
September 19, 2023
Assignee:
XELLIA PHARMACEUTICALS APS
Inventors:
Anita Bevetek Mocnik, Stipica Tomic, Barbara Fumic
Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
Type:
Grant
Filed:
October 9, 2018
Date of Patent:
September 12, 2023
Assignee:
Alpine Immune Sciences, Inc.
Inventors:
Lawrence Evans, Joseph L. Kuijper, Ryan Swanson
Abstract: The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.
Type:
Grant
Filed:
October 8, 2020
Date of Patent:
September 12, 2023
Assignee:
Ra Pharmaceuticals, Inc.
Inventors:
Steven James DeMarco, Michelle Denise Hoarty, Grace Victoria Parker, Alonso Ricardo, Sylvia Tobe, Douglas A. Treco
Abstract: A process for continuous production of C2-C4-monoalkanolamines by reaction of a corresponding C2-C4-alkylene oxide with a molar excess of ammonia (NH3), wherein aqueous ammonia is employed, in the liquid phase and in the presence of an acidic cation exchanger as catalyst which contains a crosslinked copolymer comprising acidic functional groups as the carrier matrix, wherein the cation exchanger has a total exchange capacity of not less than 1.8 eq/L.
Type:
Grant
Filed:
January 28, 2019
Date of Patent:
September 12, 2023
Assignee:
BASF SE
Inventors:
Christian Gruenanger, Gabriele Iffland, Zeljko Kotanjac, Hermann Luyken, Thomas Krug, Jian Zhong Yi, Johann-Peter Melder
Abstract: The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising no more than 0.01% (w/w) phenol, their preparation, kits comprising such compositions as well as uses thereof.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
September 12, 2023
Assignee:
Novo Nordisk A/S
Inventors:
Eva Horn Moeller, Michael Duelund Soerensen, Joakim Lundqvist
Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation.
Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.
Type:
Grant
Filed:
February 3, 2021
Date of Patent:
September 5, 2023
Assignee:
MEDIKINE, INC.
Inventors:
William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
Abstract: Disclosed herein are small molecule GIP/GLP-1 dual receptor agonist compositions, pharmaceutical compositions, the use and preparation thereof.
Type:
Grant
Filed:
November 18, 2022
Date of Patent:
September 5, 2023
Assignee:
Viking Therapeutics, Inc.
Inventors:
Brian Lian, Geoffrey E. Barker, Maureen Barnes, Kader Yagiz, Erland Stevens
Abstract: Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more modified HMG-box 1 domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
Type:
Grant
Filed:
March 14, 2018
Date of Patent:
September 5, 2023
Assignee:
Research Institute at Nationwide Children's Hospital
Inventors:
Steven David Goodman, Lauren O. Bakaletz
Abstract: A method of reducing color in an alkanolamine is described. The method includes contacting the alkanolamine with a color-reducing amount of a borane complex effective to provide a color-reduced alkanolamine composition having a Platinum-Cobalt Color Value, according to Test Method ASTM D1209, of less than 50.
Abstract: The present invention relates to a method for purification of liquid compositions containing at least one sphingolipid and the use of a specific clay mineral for the purification of such liquid compositions.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
August 29, 2023
Assignee:
Clariant Produkte (Deutschland) GmbH
Inventors:
Carina Bitterwolf, Joern Kretzschmar, Lina Tubes, Benjamin Fuerst