Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, one or more substances may be delivered to a patient at a particular infusion rate while the patient's estimated glucose level is within a predetermined range. A different insulin infusion rate may then be applied if the patient's estimated blood glucose level deviates outside of the predetermined range.

Abstract: An automated reservoir filling system for a portable medical device is disclosed. The system includes a vial sealed by a septum partially filled with a liquid and a gas occupying a headspace. The system further includes a reservoir with a volume defined between a reservoir septum and a plunger head. The plunger head is coupled to a plunger arm which is further coupled to a drive system. Further included is a transfer system with a vial end that pierces the vial septum and remains in contact with the liquid, and a reservoir end that pierces the reservoir septum and remains in the reservoir volume. A controller coupled to the drive system to actuates the drive system automatically drawing fluid from the vial to the reservoir through the degas system.

Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. The housing includes a retractable guard and an interference component, e.g., a lock ring, adjacent to the retractable guard that interferes with the movement of the retractable guard. An energy source is configured for biasing the plunger to produce an injecting pressure to jet inject the medicament from the fluid chamber through the needle to an injection site.

Abstract: An injection device tip includes a body configured to be removably connected to an injection device. A needle has a first portion projecting out from the body and a second portion projecting into a space within the body. The body includes at least one of; at least one slot separating flexible portions which can be deflected outwardly to cause release of an engagement between the body and a proximal end of the injection device, at least one slot separating flexible portions which can be deflected outwardly to cause release of a thread engagement, at least one frangible connection arranged on the body, at least one indicator arrangement on the body which provides a visual indication that the pen needle has been previously used, and at least one spacing separating two generally semi-circular or generally semi-cylindrical flexible portions which can be deflected outwardly.

Abstract: The disclosed devices and methods provide for the minimization of fluid extravasation during use of infusion catheters such as peripherally inserted central catheters and central venous catheters. The anti-extravasation catheter allows a surgeon to drain fluids from soft tissue surrounding an infusion site while also providing fluid inflow to a patient.

Abstract: The invention relates to a jig for microneedle array placement that is provided with a main jig body with through holes through which the microneedles of the microneedle array will pass and a guiding part that guides the microneedle array to be incorporated into the main jig body and leads the microneedles into the through holes, and a microneedle array device using the jig for microneedle array placement. The invention prevents the deformation of the skin surface during puncture and allows penetration of the microneedles to the prescribed depth under the skin.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A needleless valve system includes a cannula comprising a cannula tip; a valve comprising a valve tip, wherein the valve is disposed around the cannula; and a housing comprising a housing tip, wherein the cannula tip, the valve tip, and the housing tip comprise a flat surface when the needleless valve system is in a sealed position.

Abstract: An infusion system having an integrated inserter and infusion set (10) for containing and placing a flexible catheter (40), and a retractable introducer needle (26), wherein the catheter (40) is isolated from movement after placement. The integrated inserter and infusion set (10) includes a hub (20), having a user push button (30) to activate the device for catheter (40) placement. An adhesive liner (34) can be provided to cover an adhesive layer (36), such as pressure sensitive adhesive (PSA), on the bottom of the device (10).

Abstract: A circuit configured for connecting an electrode to a catheter or sheath is disclosed. The circuit includes a member having a longitudinal axis and configured to extend along at least a portion of the length of the catheter or sheath. The circuit further includes a trace printed on the member, where the trace includes at least a longitudinal segment extending generally along at least a portion of the longitudinal axis and a transverse segment extending generally transverse to the longitudinal axis. In an embodiment, the circuit further includes a pad integral with and extending from the circuit proximal the transverse segment of the trace. A catheter or sheath assembly comprising the circuit and an electrode connected to the circuit is also disclosed. A method of forming a catheter or sheath assembly is also provided.

Abstract: An injection device includes a syringe having a body with a piston disposed therein with an open end along with a viscous fluid disposed in the body for injection by the piston. A needle assembly is provided which includes a cannula having a luer connection engageable with the syringe distal end with the luer connector including a hub. Mating engagement is provided by way of internal threads at the syringe distal end and external threads of a hub with a pitch sufficient to prevent detachment of the hub from the syringe distal end during ejection of the viscous fluid. In addition, a stepped cavity, disposed in the hub, further prevents detachment of the hub from the syringe distal end during ejection of the viscous fluid.

Abstract: A dressing, for use in securing an infusion set on a skin surface, the dressing consisting of a film having a skin contacting surface and a non-skin-contacting surface, the skin-contacting surface being provided with an adhesive; a releasable backing layer provided on the non-skin-contacting surface of the film; a releasable liner provided on the skin-contacting surface of the film layer and overlaying the adhesive wherein an aperture is provided having a first portion extending from an edge of the film, backing layer and liner opening into a second portion having a geometry which is identical or substantially similar to the geometry of the perimeter of the hub of an infusion set, and wherein at least one handle is provided between the film and the liner.

Abstract: A compliant surgical device such as a flexible entry guide employs tendons to operate or steer the device and attaches asymmetric or constant force spring systems to control tension in the tendons. As a result, the surgical device can be compliant and respond to external forces during a surgical procedure without rapidly springing back or otherwise causing a reaction that damages tissue. The compliance also permits manual positioning or shaping of the device during or before insertion for a surgical procedure without damaging the tendons or connections of the tendons within the device or to a backend mechanism.

Abstract: The present disclosure relates to a medical catheter including an elongate catheter member defining a longitudinal axis and having a proximal end, a distal end, an outer wall, and first and second internal lumens. The outer wall of the catheter member includes a first opening in fluid communication with the first internal lumen to facilitate the establishment of a first flow stream, and a second opening in fluid communication with the second internal lumen to facilitate the establishment of a second flow stream. Each of the first and second openings includes proximal and distal tapered portions that are connected by an intermediate portion having a constant transverse dimension. The configurations, dimensions, and positioning of the first and second openings optimizes separation of the first flow stream from the second flow stream in order to reduce the likelihood of recirculation between the first and second internal lumens.

Abstract: Some embodiments of a medical device anchor system includes an anchor sleeve and a catheter (or other medical instrument) to advance through a working channel of the anchor sleeve. The anchor sleeve may have a subcutaneous cuff device arranged along an outer surface. In such circumstances, the embedded cuff device can inhibit the migration of infection from outside the skin and into the blood stream.

Abstract: This syringe has an outer tube, a gasket, and a pusher. The pusher is provided with: a tubular holding part which covers at least a part of an outer surface of the outer tube and is movable relative to the outer tube in the longitudinal direction thereof; and a pressure part which is connected with the holding part, is inserted into the outer tube, and moves the gasket to the distal side of the outer tube by distally a movement of the holding part relative to the outer tube. In addition, between the holding part and the outer tube, a guide part is provided which guides the movement of the holding part relative to the outer tube.

Abstract: A connector for a medical use comprising a fitting secured to a chamber, the fitting being provided at its center with a needle encased at least in its terminal portion in the recess of an elastic seal having, across the thickness of its free end, a slit or the like, the elastic seal being further provided with a ring. A terminal end of the elastic seal has a deformable peripheral rim overlapping the end of said ring.

Abstract: An assembly for the administration of a selected dosage of insulin or other medicaments from a cartridge by moving a plug guided in said cartridge, comprises an adapter assembly for adapting cartridges with different dimensions or contents. The adapter assembly comprises a first threaded element threaded with a thread lead and movable in a moving direction to move the plug, and a second threaded element threaded with a thread lead for setting a selected dosage, pivotably screwed to said first threaded element and limiting the movement of said first threaded element, and wherein said thread lead of said first element and said thread lead of said second threaded element are adapted to the dimensions and/or the contents of said cartridge.

Abstract: A system (101) for treatment of an epithelial tissue layer (3) is provided. The system comprises a reservoir (107), for containing an amount of a flowable medium, arranged to enable the medium, when contained in the reservoir, to be in contact with a surface (5) of the epithelial tissue layer, a light source (109) for generating a laser beam (11) during at least a predetermined pulse time, and an optical system for focusing the laser beam into a focal spot (15), and for positioning the focal spot in a target position. The target position of the focal spot is within the reservoir and within the medium, when contained in the reservoir, and the dimension of the focal spot and the power of the generated laser beam are such that, in the focal spot, the laser beam has a power density, which is above the characteristic threshold value for the medium, above which, for the predetermined pulse time, a laser induced optical breakdown event occurs in the medium.