Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a housing, a mechanism member movable in a first axial direction relative to the housing during dose setting and movable in a second, opposite axial direction relative to the housing during injection, wherein the mechanism member is designed and arranged such that the mechanism member is able to change its condition between a first condition preventing movement in the second axial direction and a second condition allowing movement in the second axial direction, and a switching member forcing the mechanism member to change from its second condition into its first condition at a predefined position of the movement in the first axial direction during dose setting.

Abstract: An electrosurgical instrument for treating tissue includes a housing having a shaft extending therefrom having an axis A-A defined therethrough. The shaft is at least partially flexible and includes first and second jaw members attached at a distal end thereof. Each jaw member includes an electrically conductive tissue contacting surface adapted to connect to a source of electrosurgical energy such that the electrically conductive tissue contacting surfaces are capable of conducting electrosurgical energy through tissue held therebetween. A drive assembly is disposed in the housing and has a first actuator operably coupled to a drive rod for reciprocation thereof to move the jaw members from a first position in spaced relation to one another to a second position closer to one another for engaging tissue. A second actuator is disposed on the housing and is actuatable to articulate the shaft.

Abstract: This disclosure relates to drug delivery devices, systems, and methods. In some aspects, a drug delivery device includes an elongate member defining a fluid passage and an opening in fluid communication with the fluid passage, and a projection extending radially from the elongate member. A portion of the elongate member extending axially from the projection to a distal end of the elongate member has a length sufficient to allow the distal end of the elongate member to reach subdermal tissue of a patient when the elongate member is inserted into the patient and the projection is in contact with an outer surface of skin of the patient, and the opening is positioned at a location along the elongate member such that the opening is disposed within a dermis of the patient when the elongate member is inserted into the patient and the projection is in contact with the outer surface of the skin of the patient.

Abstract: A device and system for removing polyps is provided and includes a tubular member having proximal and distal ends, a snare portion operably extending from within the distal end of the tubular member, the snare portion including a cutting member for severing the sealed tissue. The polyp removal device may further include a handle portion operatively extending from within the proximal end of the tubular member. The handle portion may be configured for operable engagement by a user and the cutting member may extend between distal ends of the first and second electrodes.

Abstract: A drug delivery device comprising; a housing; a cylindrical member configured to be rotatably supported inside the housing, wherein the outer surface of the cylindrical member is provided with a track comprising a sequence of encoded images; and a sensor directed at the track of the cylindrical member and configured to detect features of the encoded images.

Abstract: One embodiment of the present invention discloses a balloon catheter employing a reinforced, co-axial, duel lumen design. In certain embodiments, at least one of the lumens is formed of a multilayer, tubular element in which one of the layers functions, in part, to provide radial reinforcement to the tubular element.

Abstract: An insertion tool for inserting a catheter into a patient's body is disclosed. The insertion tool unifies needle insertion, guidewire advancement, and catheter insertion in a single device. In one embodiment, the insertion tool comprises a housing in which at least a portion of the catheter is initially disposed, a hollow needle distally extending from the housing with at least a portion of the catheter pre-disposed over the needle, and a guidewire pre-disposed within the needle. A guidewire advancement assembly is also included for selectively advancing the guidewire distally past a distal end of the needle in preparation for distal advancement of the catheter. In one embodiment a catheter advancement assembly is also included for selectively advancing the catheter into the patient. Each advancement assembly can include a slide or other actuator that enables a user to selectively advance the desired component. Guidewire and catheter advancement assemblies are also disclosed.

Abstract: The present disclosure relates to a drug delivery device, in particular pen-type injectors, wherein a number or pre-set doses can be administered. In particular, the present disclosure relates to such drug delivery devices, where a user may activate the dose injection process and wherein the user is still able to control the dose injection process even after a dose injection process has been activated. The process of injecting a dose is supported by some kind of energy storing means as well as by a force to be exerted by a user. Moreover, the disclosure characterizes by a reduced amount of mechanical components.

Abstract: A dose setting mechanism for a drug delivery device. The mechanism may comprise a drug delivery device housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A split threaded insert is in threaded engagement with the dose dial component. The insert can transform from a first configuration to a second configuration when the dose dial component is rotated. In one dose setting mechanism arrangement, the first configuration may comprise a first open configuration and the second configuration may comprise a second closed configuration.

Abstract: The present embodiments provide apparatus and methods suitable for delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through container towards the target site. In an alternative embodiment, the container and the pressure source may be coupled to first and second inlet ports of a connecting member, respectively, such that the therapeutic agent flows through an outlet port of the connecting member and towards the target site.

Abstract: A system, device and method are presented for utilizing stretchable active integrated circuits with inflatable bodies. The invention allows for such operative features to come into direct contact with body structures, such as the inner wall of a lumen. Such direct contact increases accuracy of measurement and delivery of therapy.

Abstract: A dose setting mechanism for a drug delivery device is provided comprising a dose setting member and a further element. Maximum dose stop features are provided on a housing and on the further element.

Abstract: A dispensing assembly has a dispensing chamber housing, a temperature control device, a thermal sensor, and an interface. The dispensing chamber housing has an inner surface, an outer surface, and a wall thickness. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The temperature control device at least partially surrounds the dispensing chamber housing. The temperature control device alters a temperature of a substance in the dispensing chamber. The temperature control device and the thermal sensor are located on a substrate. The substrate is wrapped around an exterior surface of the dispensing chamber housing. The interface is connected to the temperature control device and the thermal sensor. An interface connector is connected to the interface. The distance between the temperature control device and the thermal sensor is approximately equal to the wall thickness of the dispensing chamber housing.

Abstract: A hemodialysis catheter with an integrated means of displacing away from each other portions of a distal end of a tube assembly. The displacement serves to allow a fibrous sheath to be disrupted without removing the catheter from a patient.

Abstract: A steerable endoluminal device adapted for delivery into a patient's vasculature. The device includes a tubular member having a distal deflection portion that extends to the distal end and a main body portion that extends from the deflectable portion to the proximal end, the tubular member further including a stiff portion extending along the distal deflection portion, and being formed of polymeric material, which is disposed circumferentially adjacent to the stiff portion. The stiff portion is made of a material that has an elastic modulus greater than the elastic modulus of the polymeric material. A pull wire extends between the proximal end and the distal end of the tubular member and is attached to the distal deflection portion to control deflection of the distal deflection portion of the tubular member.

Abstract: For controlling the movement of the push device of a pump of the syringe driver-type, the pump comprising a casing (100), a syringe cradle (200) for a syringe (400), a push device (300) mobile relative to the casing (100) and capable of being driven in rotation parallel to the longitudinal axis of the syringe by driving means, clutch means (310, 350, 351) for engaging or disengaging the push device on the driving means, the push device is disengaged from the driving means, in order to move it manually, and the presence or absence of a contact between the push device and the syringe head is determined. If the push device is not in contact with the syringe head, it is advanced manually. Blocking of the advance movement of the push device is triggered only if, at the beginning, the push device was not in contact with the syringe head.

Abstract: A balloon catheter, in particular for delivering medicaments, stents or medicament-coated stents in the region of a stenosis, comprising an outer shaft (4) an inner shaft (6), and a balloon (7) at the distal catheter end, which balloon is dilatable by a feedable pressure fluid and which is attached with its proximal end (8) to the outer shaft (4) and with its distal end (9) to the inner shaft (6) which protrudes the outer shaft (4) in the distal direction, and a cover sheath (15) which is seated in a covering position over the contracted balloon (7) and is displaceably guided on the outer shaft (4) and which is displaceable on the outer shaft (4) in the proximal direction via its front opening (17) by the dilating balloon (7) while continuously releasing the same from distal to proximal.

Abstract: An injection device 110 is described having a housing 112 that receives a syringe 114 having a needle 118, wherein the syringe is supported in a syringe carrier 150. The syringe 114 and syringe carrier 150 are biased by a return spring 126 from an extended position in which the needle 118 extends from the housing 112 through an exit aperture 128 to a retracted position in which it does not. A drive spring 130 acts via a drive to advance the syringe 114 from its retracted position to its extended position and discharge its contents through the needle 118 and a return spring 126, brought into play when the drive has reached a nominal return position, restores the syringe 114 to its retracted position. The syringe carrier 150 is designed to restrict rearward movement of the syringe so that the injection device is less prone to failure and damage to is components than prior art devices.

Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.

Abstract: A catheter integral with a valved needle-free connector provides a safety catheter device configured to receive a blunt cannula and sharp needle forming an insertion mechanism. The sharp needle is mounted within a needle tube and a control handle is used to slide the sharp needle out of and into the protective needle tube. When the insertion mechanism is mounted to the connector and the control handle is used to slide the sharp needle out of the tube, a blunt cannula first moves into contact with and enters the bore of the valve mechanism of the connector opening it and protecting it from damage that may be caused by the sharp needle. The sharp needle is then extended through the connector and extends out the distal end of the catheter so that a venipuncture procedure may be performed to properly locate the catheter in the patient's circulatory system. Once located, the needle may be retracted into the insertion mechanism, the insertion mechanism disconnected from the connector, and discarded.