Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.
Type:
Grant
Filed:
August 26, 2022
Date of Patent:
March 12, 2024
Assignee:
TEXAS MEDICAL CENTER
Inventors:
Timothy J. Keane, Jr., Peter Alexander Smith, Stephen G. Ramon
Abstract: Embodiments of the present disclosure, in one aspect, relate to compositions including a vacancy-engineered (VE)-ZnO nanocomposite, methods of making a composition, methods of using a composition, and the like.
Type:
Grant
Filed:
November 25, 2022
Date of Patent:
February 27, 2024
Assignee:
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Abstract: Described herein are nasal pharmaceutical compositions comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located inside pores of the porous excipient, and wherein the composition is adapted for nasal administration. Also described herein are methods of making and using nasal pharmaceutical compositions.
Abstract: A peptide composition and methods for slimming and/or for promoting the growth of probiotics using early harvested rice prebiotics are provided. The peptide composition or the early harvested rice prebiotics includes at least one peptide as set forth in: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 and SEQ, ID NO: 8.
Abstract: A method of targeting to the synovial tissue biodegradable drug delivery compositions or morselizing biodegradable drug delivery compositions are described. The biodegradable drug composition comprises a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as at least one pharmaceutically active principle is disclosed.
Type:
Grant
Filed:
January 25, 2021
Date of Patent:
January 9, 2024
Assignee:
MEDINCELL S.A.
Inventors:
Georges Gaudriault, Sylvestre Grizot, Mark Hurtig, Matthew Shive
Abstract: Disclosed are a peptide capable of induced self-assembly by a bioactive molecule comprising a (i) hydrogelation-promoting amino acid sequence and (ii) an oligomerization sequence; compositions containing the peptide and, optionally, bioactive molecule; hydrogels formed thereby; and various methods of using the same.
Abstract: The invention provides compositions and methods that comprise encapsulated silver diamine fluoride or other antimicrobial materials for use in treatment of dental caries, for example.
Abstract: Suspensions of pump inhibitors (PPIs) are disclosed. The suspension may include a PPI, a copolymer of ethylene oxide and propylene oxide; simethicone emulsion; Sodium Bicarbonate; and Sodium Citrate, USP (Dihydrate). The suspensions have desirable viscosities and enhanced stability.
Type:
Grant
Filed:
December 17, 2021
Date of Patent:
November 14, 2023
Assignee:
AZURITY PHARMACEUTICALS, INC.
Inventors:
Ken Fallin, Kaity Renaud, Peter Mione, Neal Muni, Anisa Gandhi
Abstract: The present invention relates to polyoxazoline polymers, polymer combinations and compositions comprising those polymers or combinations of polymers. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.
Type:
Grant
Filed:
March 18, 2019
Date of Patent:
October 24, 2023
Assignee:
Universiteit Gent
Inventors:
Maarten Vergaelen, Richard Hoogenboom, Victor Retamero de la Rosa, Chris Vervaet, Aseel Samaro, Valérie Vanhoorne
Abstract: Provided is an injectable implant configured to fit at or near a bone defect to promote bone growth, the injectable implant comprising lyophilized demineralized bone matrix (DBM) being in fiber and particle forms; alginate; and a liquid carrier, wherein the DBM is in an amount of about 20 wt. % to about 40 wt. % of a total weight of the injectable implant, the alginate is in an amount of from about 3 wt. % to about 10 wt. % of the total weight of the injectable implant, and the liquid carrier is in an amount from about 50 wt. % to about 70 wt. % of the total weight of the injectable implant. A moldable implant and methods of making the implants are further provided.
Abstract: The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.
Type:
Grant
Filed:
July 27, 2021
Date of Patent:
October 10, 2023
Assignee:
FEMASYS INC.
Inventors:
Kathy Lee-Sepsick, Lani L. L. Paxton, Jeffrey A. Marcus, Stephen N. Williams
Abstract: Disclosed herein are methods of improving skin appearance associated with skin aging. The method comprises the step of applying an anti-aging bioactive composition to a skin surface having at least one sign of aging. The anti-aging bioactive composition is applied for a period of time sufficient to improve the appearance of the at least one sign of aging. In one embodiment, the anti-aging bioactive composition comprises an effective amount of a Nelumbo nucifera (Sacred Lotus) serum fraction. In another embodiment, the anti-aging bioactive composition comprises an effective amount of a Chamomilla recutita (German Chamomile) Flower serum fraction. In other embodiments, the anti-aging bioactive composition can further include a dermatologically acceptable carrier.
Type:
Grant
Filed:
October 19, 2021
Date of Patent:
September 26, 2023
Assignee:
ISP INVESTMENTS LLC
Inventors:
Olga Dueva-Koganov, Artyom Duev, Li Zhang, Karine Cucumel, Gilles Oberto
Abstract: The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.
Type:
Grant
Filed:
August 27, 2021
Date of Patent:
September 5, 2023
Assignee:
AI Therapeutics, Inc.
Inventors:
Henri Lichenstein, Jonathan M. Rothberg, Thomas Armer, Lawrence S. Melvin, Jr.
Abstract: Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.
Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
September 5, 2023
Assignee:
UPM-KYMMENE CORPORATION
Inventors:
Markus Nuopponen, Lauri Paasonen, Anne Meriluoto, Jukka Rissanen, Harri Jukarainen
Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed to yield a stabilizing effect without altering morphological properties of a first fiber system. By addition of a stabilizing fiber population one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. In one particular abstract, medical barrier materials may be formed from the electrospun materials to provide improved medical barriers for treatments.
Type:
Grant
Filed:
January 30, 2015
Date of Patent:
August 29, 2023
Assignee:
Poly-Med, Inc.
Inventors:
Michael Scott Taylor, Seth Dylan McCullen, David Shalaby
Abstract: The present invention provides oral care compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more plasticizers, benzocaine (and optionally one or more further active ingredients), one or more polymeric solvents, and an aqueous solvent. The oral care composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral care compositions are also provided herein.
Type:
Grant
Filed:
August 12, 2021
Date of Patent:
August 15, 2023
Assignee:
Church & Dwight Co., Inc.
Inventors:
Sarah Lindsay Grant, Dominic Gregory Walsh, Mark Alexander Livingstone