Abstract: Ophthalmic formulations containing nintedanib, or a pharmaceutically acceptable salt thereof are provided. The ophthalmic formulations can contain microparticles or nanoparticles of nintedanib. Also provided are methods of using the ophthalmic formulations for treating ocular surface diseases, such as dry eye disease.
Abstract: Compositions that are suitable for use as a disinfectant are disclosed. Methods of making and using compositions that are suitable for use as a disinfectant are also disclosed.
Abstract: The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.
Abstract: The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.
Abstract: The present disclosure relates to hair care and conditioning compositions; and to methods for conditioning, managing, and/or styling the hair using the compositions. The hair conditioning and managing compositions are substantially anhydrous and include: propylene glycol; one or more monoalcohols having from 2 to 6 carbon atoms; one or more cationic surfactants; and one or more fatty compounds. The compositions are solubilized, non-emulsified compositions until applied to wet or damp hair, whereupon the compositions form a lamellar phase in situ.
Abstract: The present invention is directed to an aripiprazole oral soluble film and a preparation method thereof. The aripiprazole oral soluble film comprises 10-60% w/w of aripiprazole in a crystalline state and 30-95% w/w of one or more film-forming materials, wherein 90% of the aripiprazole particles have a size of ?14.3 ?m and are uniformly blended in the film without visible undispersed particles. The aripiprazole oral soluble film has excellent bioavailability, uniformity, stability, and palatability. The oral soluble film preparation is prepared by first grinding aripiprazole particles to have desired small particle sizes, then blending the aripiprazole particles with film forming materials in an aqueous solution to a uniform suspension, defoaming the suspension, and coating the suspension on a substrate and drying it to form a film.
Abstract: The invention relates to a shampoo composition for enhancing deposition of oil drop onto a substrate, comprising a mixture of sulfonated methyl ester compounds containing two or more sulfonated methyl esters of a fatty acid having a chain length of 12 to 20 carbon atoms (C12-C20); a zwitterionic surfactant; an oil phase; and a cationic polymer. The shampoo composition may further comprise an inorganic electrolyte such as sodium chloride. The invention also relates to use of the shampoo composition for enhancing deposition of oil drop onto a substrate, wherein the composition comprises a specific blend of sulfonated methyl ester compounds.
Type:
Grant
Filed:
December 17, 2020
Date of Patent:
May 3, 2022
Assignee:
KL-KEPONG OLEOMAS SDN BHD
Inventors:
Peter Atanassov Kralchevsky, Rumyana Dobreva Stanimirova, Jordan Todorov Petkov, Hui Xu
Abstract: The invention relates to a shampoo composition for enhancing deposition of oil drop onto a substrate, comprising a mixture of sulfonated methyl ester compounds containing two or more sulfonated methyl esters of a fatty acid having a chain length of 12 to 20 carbon atoms (C12-C20); a zwitterionic surfactant; an oil phase; and a cationic polymer. The shampoo composition may further comprise an inorganic electrolyte such as sodium chloride. The invention also relates to use of the shampoo composition for enhancing deposition of oil drop onto a substrate, wherein the composition comprises a specific blend of sulfonated methyl ester compounds.
Type:
Grant
Filed:
August 30, 2018
Date of Patent:
May 3, 2022
Assignee:
KL-KEPONG OLEOMAS SDN BHD
Inventors:
Peter Atanassov Kralchevsky, Rumyana Dobreva Stanimirova, Jordan Todorov Petkov, Hui Xu
Abstract: The present invention relates to a composition comprising a lithium salt of an N-substituted glycine compound and a carrier, wherein the lithium salt of the N-substituted glycine compound is of Formula (I): in which R1, R2, and R3 each are independently hydrogen, alkyl, alkenyl, alkynyl, aralkyl, carbocyclyl, aryl, or heteroaryl, or one of R1, R2, and R3 is absent. Also provided in the present invention is a method of mitigating at least one symptom of a neuropsychiatric disorder, comprising administering to a subject in need thereof the lithium salt of an N-substituted glycine compound of Formula (I).
Type:
Grant
Filed:
January 18, 2019
Date of Patent:
March 22, 2022
Assignee:
SyneuRx International (Taiwan) Corp.
Inventors:
Guochuan Emil Tsai, Ching-Hsun Huang, Han-Yi Hsieh, Jing-Jia Huang, Ching-Cheng Wang
Abstract: A lutein microcapsule formulation and preparation method thereof, the formulation comprising the following ingredients: lutein crystals, a water-soluble emulsifier, an oil-soluble antioxidant, a wall material, a filler, a water-soluble antioxidant, and purified water. The preparation method comprises: dissolving the lutein crystals and the oil-soluble antioxidant in the water-soluble emulsifier to obtain an oil phase; adding the wall material, the water-soluble antioxidant, and the filler to the purified water to obtain a water phase; adding the oil phase to the water phase, grinding to obtain a particle size of the liquid emulsion of less than 100 nm, and granulating.
Abstract: Implants comprising an antimalarial agent such as decoquinate or another therapeutic drug are disclosed. The implants can be in the form of a complex comprising a drug, a lipid or lipids and optionally a polymer carrier. The present invention provides methods for preparing implants wherein the implants comprise decoquinate or another therapeutic drug, and a lipid or lipids such as cholesterol, monoglycerides, or diglycerides, and optionally a small percentage of a biocompatible polymer based on the total implant weight. The implants are useful for releasing a therapeutic drug at a constant level and maintaining a prophylactic or therapeutic level of the drug in a subject, for preventing a malarial infection or treating other diseases or disorders.
Abstract: The invention provides pharmaceutical compositions comprising a dry medicament. The dry medicaments can be rapidly dissolved, solubilized, and/or reconstituted to deliver to a subject. The present invention provides methods of preparing a medical solution. The medical solution can be prepared from mixing the pharmaceutical composition as described herein with a first liquid.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
February 15, 2022
Assignee:
Windgap Medical, Inc.
Inventors:
Adam R. Standley, Kaliappanadar Nellaiappan, Brent A. Buchine
Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
Type:
Grant
Filed:
June 30, 2015
Date of Patent:
January 25, 2022
Assignee:
President and Fellows of Harvard College
Inventors:
Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay Uzun
Abstract: Compositions containing iron, buffering agent and denatured protein have been prepared that are capable of increasing serum iron in a subject. For example, spray dried microbeads have been prepared containing iron entrapped within a protein matrix and unbound iron in a buffered composition that provides a gastroprotective effect, preserves iron in the more available Fe2+ form and improves iron bioavailability in humans relative to previously known vehicles for delivering iron to a subject.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
January 18, 2022
Assignee:
SOLVOTRIN THERAPEUTICS LTD
Inventors:
John Gilmer, Radics Gabor, Michael Whelehan, Jun Wang, Pat O'Flynn, Mark Ledwidge
Abstract: The present invention relates to topical composition comprising a cetyl phosphate surfactant mixture consisting essentially of mono- and/or dicetyl esters of phosphoric acid or salts thereof and cetylalcohol and inorganic phosphate and heavy metals and water, characterized in that the surfactant mixture contains no organochlorine impurities and has an inorganic phosphate content of less than 0.7 wt.-% and a heavy metal content of less than 12 ppm.
Type:
Grant
Filed:
June 27, 2017
Date of Patent:
January 18, 2022
Assignee:
DSM IP ASSETS B.V.
Inventors:
Andre Duesterloh, Anne Janssen, Christeine Mendrok-Edinger, Karina Radomsky, Thomas Rudolph
Abstract: The present invention relates to a modified-release composition of mazindol and its use in the treatment of attention deficit disorders (ADD) or attention deficit/hyperactivity disorder (ADHD) or related deficit of alertness (i.e., incoercible sleepiness) or decline of vigilance (i.e., daytime somnolence) or excessive daytime sleepiness (e.g., narcolepsy, idiopathic hypersomnia) in particular in children, adolescents and adults.
Type:
Grant
Filed:
March 8, 2017
Date of Patent:
December 28, 2021
Assignee:
NLS Pharmaceutics AG
Inventors:
Alexander C. Zwyer, Lewis P. Amsel, Virginia Schmith, Scott Brantley
Abstract: Suspensions of pump inhibitors (PPIs) are disclosed. The suspension may include a PPI, a copolymer of ethylene oxide and propylene oxide; simethicone emulsion; Sodium Bicarbonate; and Sodium Citrate, USP (Dihydrate). The suspensions have desirable viscosities and enhanced stability.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
December 28, 2021
Assignee:
AZURITY PHARMACEUTICALS, INC.
Inventors:
Ken Fallin, Kaity Renaud, Peter Mione, Neal Muni, Anisa Gandhi
Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices are described.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
November 30, 2021
Assignee:
MicroVention, Inc.
Inventors:
Gregory M. Cruise, Michael Constant, Terrance Tran, Joseph Gulachenski
Abstract: The present invention relates to a sustained-release pharmaceutical composition intended for animal use, which comprises a drug, a sugar, a wax, and a water-soluble polymer.