Patents Examined by William H. Beisner
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Patent number: 11965149Abstract: The shock tube comprises a tube, a first electrode, a second electrode and a stopple, wherein the tube is internally provided with a cavity for accommodating a target liquid sample. The first electrode is arranged at one end of the tube. The second electrode is arranged in the stopple, and the outer end of the second electrode can be electrically connected with the exterior via an opening of the stopple. The stopple is internally provided with an elastic piece connected with the second electrode. The outer side of the elastic piece is connected with the stopple, and the inner side of the elastic piece is connected with the second electrode. The invention further provides a cell electroporation device where the shock tube can be placed.Type: GrantFiled: September 29, 2019Date of Patent: April 23, 2024Inventor: Jian Chen
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Patent number: 11959060Abstract: Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.Type: GrantFiled: May 15, 2020Date of Patent: April 16, 2024Assignee: HUMACYTE, INC.Inventors: Heather L. Prichard, Dustin Cashman, Joshua McCall, Laura E. Niklason, Benjamin Orbon, Justin T. Strader
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Patent number: 11952565Abstract: An electrical stimulation device includes a terminal electrode having an opening at a center thereof, a ground electrode having an area smaller than that of the terminal electrode, and a power source connected to the terminal electrode and the ground electrode and configured to apply an electrical stimulus to an object disposed between the terminal electrode and the ground electrode by applying a terminal voltage to the terminal electrode.Type: GrantFiled: January 13, 2021Date of Patent: April 9, 2024Assignee: Samsung Electronics Co., Ltd.Inventors: Don-Wook Lee, Young Jun Hong
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Patent number: 11946032Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.Type: GrantFiled: March 18, 2019Date of Patent: April 2, 2024Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre VAnhaver
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Patent number: 11948307Abstract: A solid-liquid boundary detection device 20 is a device for detecting a boundary 141 between a solid and a liquid in a test tube 14, and includes a surface illumination 21, an imaging unit 22, and a boundary detection processor 31. The surface illumination 21 illuminates the test tube 14 from outside. The imaging unit 22 is arranged on an opposite side of the test tube 14 from the surface illumination 21, and captures an image including the boundary 141. The boundary detection processor 31 detects the boundary 141 from the image captured by the imaging unit 22.Type: GrantFiled: July 10, 2019Date of Patent: April 2, 2024Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, SHIMADZU CORPORATIONInventors: Tsutomu Watanabe, Naoki Takamura, Tomohisa Hasunuma
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Patent number: 11944975Abstract: A thermal cycler system comprises a sample block configured to receive a sample holder configured to receive a plurality of samples; an adaptor configured to surround a periphery of the sample block; and a drip pan configured to surround a periphery of the adaptor. The drip pan comprises one or more ejector mechanisms and one or more openings, the one or more ejector mechanisms configured to respectively extend through the one or more openings into contact with the sample holder in a state of the sample holder received by the sample block and the adaptor surrounding the periphery of the sample block.Type: GrantFiled: December 29, 2022Date of Patent: April 2, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Zeqi Tan, Wuh Ken Loh, Siew Yin Lee, Kuan Moon (Bernard) Boo
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Patent number: 11939565Abstract: Provided herein is a method for incubating living cells, in accordance with principles of the disclosure, may include the steps of: (a) providing a pressurized gas to a medium reservoir, the pressurized gas providing an impetus that moves a growth medium in the medium reservoir to a bioreactor chamber via a first incoming fluid line connecting the medium reservoir to the bioreactor chamber; (b) simultaneously or subsequently to step (a), providing a pressurized gas to a cell reservoir holding a suspension of the living cells, the pressurized gas providing an impetus that moves the suspension to the bioreactor chamber via a second incoming fluid line connecting the cell reservoir to the bioreactor chamber; and (c) incubating the growth medium and the living cells in the bioreactor chamber, under conditions compatible with cell viability.Type: GrantFiled: June 28, 2023Date of Patent: March 26, 2024Assignee: Trisk Bio Ltd.Inventors: Gergo Bohner, Adam Luke Hiles, Samuel Isidor Jones, Kevin Lynagh, Ryan Olf, Gabor Pap, Spencer Ryan Wilson, Thomas Felix Martin Cummings
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Patent number: 11932840Abstract: A bioreactor includes a container (1) composed of at least one side wall (11), a bottom wall (12) and an opening (13) closed by a cap (14), such to identify an inner chamber. An intermediate wall (2) is inside the inner chamber, to divide the inner chamber in an upper chamber (31) and a lower chamber (32). The intermediate wall (2) has at least one hole (21). The intermediate wall (2) has at least one region resting on the bottom wall and/or the side wall and provides at the hole (21) at least one housing seat (26) for a membrane (22).Type: GrantFiled: January 15, 2018Date of Patent: March 19, 2024Assignee: REACT4LIFE S.R.L.Inventors: Silvia Scaglione, Maurizio Aiello, Marta Maria Cavo
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Patent number: 11932841Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.Type: GrantFiled: July 25, 2017Date of Patent: March 19, 2024Assignee: UBE CORPORATIONInventors: Masahiko Hagihara, Shinsaku Fuse, Motohisa Shimizu, Yukinori Wada
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Patent number: 11925899Abstract: A system for removing undesirable compounds from contaminated air includes a biofilter having sintered glass media. Hydrogen sulfide is removed from contaminated air by passing the contaminated air through the biofilter.Type: GrantFiled: May 10, 2021Date of Patent: March 12, 2024Assignee: Evoqua Water Technologies LLCInventor: Timothy Frank Matheis
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Patent number: 11920115Abstract: An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.Type: GrantFiled: August 29, 2018Date of Patent: March 5, 2024Assignees: The University of North Carolina at Chapel Hill, Cell Microsystems, Inc.Inventors: Nancy L. Allbritton, Yuli Wang, Christopher E. Sims, Nicholas C. Dobes, Steven C. Gebhart, Nicholas C. Trotta
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Patent number: 11919058Abstract: The invention relates to a method for microbial remediation of underground water petroleum hydrocarbon contamination by regulating soil buffer capability, which comprises detecting the soil particle size of contaminated site soil, dividing the contaminated site soil into coarse-grained soil and fine-grained soil; dividing the contaminated site soil into high buffer capacity soil and low buffer capacity soil; and adjusting the composition and ratio of a biostimulant solution added to the contaminated site soil based on the classification of the contaminated site soil. The detecting step includes classifying soil with a particle size between 0.075 mm and 60 mm and a mass greater than or equal to 50% of the total mass as coarse-grained soil; and classifying soil with a particle size not greater than 0.075 mm and a mass greater than or equal to 50% as fine-grained soil.Type: GrantFiled: May 31, 2023Date of Patent: March 5, 2024Assignee: CHENGDU UNIVERSITY OF TECHNOLOGYInventors: Shengyan Pu, Peng Wang, Shibin Liu, Xin Wang, Hui Ma, Pei An
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Patent number: 11912968Abstract: A microcavity dish (10) for cultivating cells includes a dish body including a sidewall (16) that encloses a cell culture chamber within the dish body. The dish body has a top and a bottom (12). The bottom includes a cell culturing substrate comprising an array of microcavities (46). The sidewall includes a transition portion (30) that divides the sidewall into an upper portion and a lower portion that is offset inward relative to the upper portion defining a liquid medium delivery surface (26) that extends at least partially along an interior surface (28) of the sidewall and slopes toward the bottom.Type: GrantFiled: July 13, 2018Date of Patent: February 27, 2024Assignee: CORNING INCORPORATEDInventors: Gregory Roger Martin, Allison Jean Tanner
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Patent number: 11912966Abstract: Aspects of the invention are directed to a system and method of sparging an algae cultivation container. The method may include controlling at least one first sparger to distribute a first fluid into the container at a first operating flow rate; and controlling at least one second sparger to distribute a second fluid into the container at a second operating flow rate. The first operating flow rate may be adapted to allow mixing the algae in the cultivation container, and the second operating flow rate may be adapted to allow assimilation of materials in a liquid in the cultivation container.Type: GrantFiled: July 22, 2019Date of Patent: February 27, 2024Assignee: VAXA TECHNOLOGIES LTDInventors: Oded Bashan, Ohad Bashan, Stephen Drummey
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Patent number: 11905546Abstract: A sample testing apparatus includes a sample tray defining a planar surface and a plurality of wells recessed relative to the planar surface, and a lid member configured to be sealed about the planar surface of the sample tray. The lid member includes an adhesive layer configured to be sealed to the planar surface of the sample tray, a breathable film layer disposed about the adhesive layer, and a backing layer disposed about the breathable film layer. Methods of using the sample testing apparatus for testing a sample and kits to facilitate such testing are also provided.Type: GrantFiled: September 14, 2021Date of Patent: February 20, 2024Assignee: IDEXX LABORATORIES INC.Inventors: Daniel H. Broder, Lawrence G. Chapper, Veronica L. Newport, Julie E. Rollins, Brian M. Swalla, Scott W. Wagner, David L. White
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Patent number: 11905505Abstract: The disclosure relates to a liquid reservoir for a food waste recycling appliance. The liquid reservoir includes a reservoir body with a hollow interior and having an exterior surface bounding an interstitial space. A food waste through opening can pass through the interstitial space. The reservoir body can also include a channel on the exterior surface.Type: GrantFiled: December 22, 2020Date of Patent: February 20, 2024Assignee: Whirlpool CorporationInventors: Akshay Bhandari, Thomas L. Burger, Rachel Maghas
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Patent number: 11905503Abstract: Generation of energy and storage of energy for subsequent use is provided by electromethanogenesis of carbon dioxide into a fuel gas and the storage of the fuel gas for subsequent use. An electromethanogenic reactor includes an anode conductor and a cathode conductor wherein the cathode conductor includes submicron to micron scale pores. Electromethanogenesis microbes and/or enzymes are located in the micron scale pores of the cathode electrode conductor. Carbon dioxide is introduced into the electromethanogenic reactor and the electromethanogenesis microbes/enzymes and the carbon dioxide interact and produce a fuel gas. The fuel gas is stored for subsequent use, for example use in power generation.Type: GrantFiled: August 3, 2021Date of Patent: February 20, 2024Assignee: Lawrence Livermore National Security, LLCInventors: Jennifer Marie Knipe, Sarah E. Baker, Marcus A. Worsley, Swetha Chandrasekaran
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Patent number: 11906454Abstract: A microcalorimeter device capable of measuring cellular bioenergetics and systems that are limited in analytic volume. The microcalorimeter device provides sub-nWatt resolution and even tens of pico-Watt resolution, thus enabling resolution of the metabolic rate of a single cell.Type: GrantFiled: November 13, 2017Date of Patent: February 20, 2024Assignee: President and Fellows of Harvard CollegeInventors: Jinhye Bae, Joost J Vlassak
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Patent number: 11898134Abstract: Systems and methods relating to dynamic spargers for generating fine bubbles within reactors such as biological and chemical reactors. A sparger system is positioned within a reactor and comprises a support plate, multiple annular shrouds engaged with the support plate, and spargers positioned within the annular shrouds defining a gap between an interior surface of the annular shroud and an exterior surface of the corresponding sparger. Liquid flows through the defined gap between an interior surface of the annular shroud and an exterior surface of the sparger. Acceleration of the liquid through the gap shears bubbles at the exterior surface of the sparger creating bubbles or fine bubbles.Type: GrantFiled: October 31, 2022Date of Patent: February 13, 2024Assignee: LanzaTech, Inc.Inventors: Mayur Sathe, Joss Anton Coombes, Robert John Conrado, Gregory Joseph Morin
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Patent number: 11891597Abstract: An automatic processing device of culture plates (2) for microbiological samples, wherein the processing device (1) includes a support frame (3); a slide (4) provided with a seating (5) configured for removably housing a culture plate (2) and movably mounted on the support frame (3) so as to be selectively displaceable between a first loading position, a plurality of image-acquiring positions, and a first unloading; a camera (6) of a linear type, provided with an optic (7) of a telecentric type and a trilinear sensor, and arranged according to a vertical axis (8) such as to acquire, at an image-acquiring zone, a multiplicity of linear images of corresponding linear portions of an upper surface of the culture plate (2), during the displacing of the slide (4); a first lighting device (11) orientated such as to illuminate the linear portions of an upper surface of the culture plate (2); an advancing device (14) of the slide (4) configured such as to enable obtaining a constant and substantially vibration-free adType: GrantFiled: December 28, 2020Date of Patent: February 6, 2024Assignee: Copan Italia S.p.A.Inventor: Daniele Triva