Abstract: An earbud device having a user interface that incorporates a rotary switch is described. The rotary switch is part of a stem that extends from the main body of the earbud, and can provide file selection and/or volume control functions. The interface can include a pressure switch, which can provide switching between on, off, and sleep modes. The pressure switch can also be positioned on the stem, and in some embodiments the rotary switch can also act as the pressure switch when pressed. In some embodiments the user interface can utilize a combination of rotary switch and pressure switch inputs.

Abstract: The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.

Abstract: The present invention includes compositions and methods for treating T cell lymphomas and leukemias. In certain aspects, the compositions and methods include CAR T cells targeting CD2, CD5, or CD7 and modified cells wherein CD2, CD5, or CD7 has been knocked-out.

Abstract: Provided is a chimeric antigen receptor (CAR) comprising a domain that binds a V? region of a T cell receptor. Also provided is a T cell genetically modified to express the CAR, and methods for treating cancer in a subject in need thereof.

Abstract: The invention provides methods for stimulating a universal immune receptor-mediated response in a mammal using cells engineered to express a universal immune receptor that comprises an adaptor molecule, such as a SpyCatcher or a SpyTag moiety, a transmembrane domain, and an intracellular domain for T cell activation.

Abstract: Methods are provided that utilize irradiation to selectively induce release of granules (such as granules containing cytokines or other therapeutically active substances) from platelets. Such irradiation can be performed ex vivo or in vivo, and can be utilized to provide a treated platelet suspension for therapeutic infusion.

Abstract: An adapter for a bearing race and seal driver tool that allows the tool to be used in hard to reach applications. The adapter connects to a driver and a handle at a non-zero angle, for example a right angle, to allow the adapter to be struck at a face of the adapter rather than the handle to be struck at an end of the handle. A pocket is included at one or more connection points between the adapter and the handle or driver to resist rotational movement of the handle or driver.

Abstract: Methods for producing and utilizing primed platelets are provided, in which platelets are primed for release of specific granule types and/or active compounds by irradiation, for example with electromagnetic radiation, an electrical field, and/or a magnetic field. Such irradiation can be performed ex vivo or in vivo. Such primed platelets have utility in treating inflammatory conditions, neurodegenerative conditions, and/or joint and tendon related injuries.

Abstract: A method for providing secure single sign on includes receiving a first data object from an application hosting server, the first data object indicating at least a service provider name and identifying a configuration file corresponding to the service provider name, wherein the configuration file includes at least trusted identity information. The method also includes determining, using the configuration file corresponding to the service provider name, whether the first data object is valid and, in response to a determination that the first data object is valid, generating a response message.

Abstract: One or more memory systems, architectural structures, and/or methods of storing information in memory devices is disclosed to improve the data bandwidth and or to reduce the load on the communication links. The system may include one or more memory devices, one or more memory control circuits and one or more data buffer circuits. The memory system, architectural structure and/or method improves the ability of the communications links to transfer data downstream to the data buffer circuits. The memory control circuit receives a store command and a store data tag (Host tag) from a Host and sends the store data command and the store data tag to the data buffer circuits. No store data tag or control signal is sent over the communication links between the Host and the data buffer circuits, only data is sent over the communication links between the Host and the data buffer circuits.

Abstract: An in-line filter uses scalar coils positioned in series with an input of a speaker to modify or enhance the audio quality and of the speaker, and its auditory effects on a user, by changing the sound signature and reducing digital noise. Scalar coils have two spiral windings with opposite winding directions. Scalar coils can also be used in series with a laser emitter that produces a laser beam that travels through the scalar coil, which produce electromagnetic forces that improve perceived audio quality in a user.

Abstract: Compositions and methods for treatment of cancer according to aspects of the present disclosure comprise compounds comprising or consisting of: structural formula (I) or (II) disclosed herein, or a salt, isomer, or derivative thereof.

Abstract: An adaptor for a press. The adaptor includes a body adapted to removably couple to the press cylinder or carriage of the press and an extension shaft having first and second opposing ends. The first end is removably coupled to the body, and the second end is adapted to couple to a drive adaptor.

Abstract: The present invention includes compositions and methods that utilize a Universal Immune Receptor (UnivIR) CAR system comprising a modified T cell comprising a DOTA CAR and a DOTA-conjugated targeting ligand. In certain embodiments, the invention includes methods for treating, ameliorating, and/or preventing cancer. In certain embodiments, the invention provides a set of complementary molecular imaging tools that is applicable to CAR T cell therapy.

Abstract: A computer-implemented method includes refreshing a set of memory channels in a memory system substantially simultaneously, each memory channel refreshing a rank that is distinct from each of the other ranks being refreshed. Further, the method includes marking a memory channel from the set of memory channels as being unavailable for the rank being refreshed in the memory channel. In one or more examples, the method further includes blocking a fetch command to the memory channel for the rank being refreshed in the memory channel.

Abstract: A method for providing secure single sign on includes receiving a first data object from an application hosting server, the first data object indicating at least a service provider name and identifying a configuration file corresponding to the service provider name, wherein the configuration file includes at least trusted identity information. The method also includes determining, using the configuration file corresponding to the service provider name, whether the first data object is valid and, in response to a determination that the first data object is valid, generating a response message.

Abstract: The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.

Abstract: The present invention relates to compositions and methods for treating HER2/Neu (ERBB2) expressing cancer cells. In some embodiments, the invention includes an isolated T cell receptor (TCR) having high affinity for and that specifically binds ERBB2369-377 epitope on a target cell. Other embodiments include a T cell or a population of T cells modified to express ERBB2-specific TCR. Further embodiments include methods of using ERBB2-specific TCR gene transfer for treating ERBB2 expressing cancer cells. Also included are methods and pharmaceutical compositions comprising the modified T cells for adoptive therapy.

Abstract: Supercooled water or solutions can be destabilized by the nucleation of ice, which can be triggered by a wide range of different mechanisms. Constraining water in a constant-volume (isochoric) container minimizes the effects of many of these mechanisms through thermodynamic, kinetic, and fluid dynamic means, significantly enhancing supercooling stability. This invention describes methods and devices for high-stability and optionally transportable supercooling of aqueous solutions or suspensions, and the stable and long-term preservation of biological matter that may be stored therein.