Abstract: The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality.

Abstract: Disclosed herein is a composite comprising an elastomer with an embedded network of liquid metal inclusions. The composite retains similar flexibility to that of an elastomer but exhibits electrical and thermal properties that differ from the properties of a homogeneous elastomer. The composite has applications for wearable devices and other soft matter electronics, among others.

Abstract: An in-line filter uses scalar coils positioned in series with an input of a speaker to modify or enhance the audio quality and of the speaker, and its auditory effects on a user, by changing the sound signature and reducing digital noise. Scalar coils have two spiral windings with opposite winding directions. Scalar coils can also be used in series with a laser emitter that produces a laser beam that travels through the scalar coil, which produce electromagnetic forces that improve perceived audio quality in a user.

Abstract: The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using PCR under specific temperature cycling conditions; and (d) detecting said amplicons. We introduce a novel molecule, Xenonucleic Acid (XNA) for the NGS library preparation. XNA is able to selectively suppress amplification of DNA with wild type alleles and amplify DNA containing mutant alleles. Mutants with low allelic frequency will be easily detectable without deep sequencing after enrichment by adding XNA in multiplex PCR. The 17 actionable mutants related to lung or colorectal cancer diseases at different variant allelic frequency (VAF) % were investigated. Clinical sensitivity is significantly improved with XNA in various types of samples.

Abstract: Multiple speakers and isobaric chambers are used to enhance sound quality in an earbud. The earbud has a housing with a sound outlet, a first and second isobaric chambers that are in communication with the outlet. Two sound drivers in the housing are positioned to emit sound waves into the isobaric chambers separately. A divider is used to guide sound waves by creating an elongated channel in the second isobaric chamber. An ear hook has a third isobaric chamber and a third sound driver positioned to emit sound wave into the third isobaric chamber. The third isobaric chamber is in communication with the outlet through the second isobaric chamber.

Abstract: The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having ?-folate receptor (FR?) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.

Abstract: A computer-implemented method for marking load and store instruction overlap in a processor pipeline is described. The method includes detecting a load instruction following a store instruction in an instruction stream. The load instruction and the store instruction include instruction text. The instruction text includes operand address information. The method includes comparing operand address information of the store instruction with operand address information of the load instruction to determine whether there is a memory image overlap in an issue queue between the operand address information of the store instruction and the load instruction. The method also includes delaying the load instruction in the processor pipeline in response to determining that there is a memory image overlap.

Abstract: In some implementations, a computing device may perform a method for providing a unified pipeline for media metadata to converge disparate schemas and data structures into a global unified graph. The method includes receiving media metadata from disparate media sources that may each have a different metadata schema that defines the structure and attributes of the metadata provided by each media source. The computing device may compare media metadata received from the different media sources to determine that metadata received from the different media sources correspond to similar, or the same, media entities (e.g., songs, movies, books, etc.). The metadata for the similar media entities may then be combined into a global unified graph that may include metadata attributes and/or values of the metadata received from the various media sources.

Abstract: The invention provides compositions and methods for treating cancer by using immune effector cells (e.g., T cells, NK cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a Chimeric Antigen Receptor (CAR). The conditional agents described herein include agents that target a cancer associated antigen, e.g., a CAR, agents that inhibit one or more checkpoint inhibitors of the immune response, and a cytokine.

Abstract: An information handling system (IHS) includes a processor with a cache memory system. The processor includes a processor core with an L1 cache memory that couples to an L2 cache memory. The processor includes an arbitration mechanism that controls load and store requests to the L2 cache memory. The arbitration mechanism includes control logic that enables a load request to interrupt a store request that the L2 cache memory is currently servicing. When the L2 cache memory finishes servicing the interrupting load request, the L2 cache memory may return to servicing the interrupted store request at the point of interruption.

Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.

Abstract: Methods of treatment of cancer, including prostate cancer, in a subject in need thereof are provided according to aspects of the present disclosure which include administering an effective amount of an inhibitor of a pro-inflammatory factor to the subject, wherein the pro-inflammatory factor is dysregulated in the subject, and wherein the inhibitor is an inhibitor of a pro-inflammatory factor selected from the group consisting of: interleukin-1?, interleukin-6, interleukin-8, interleukin-10, stromal cell-derived factor-1?, matrix metallopeptidase 9, epithelial-derived neutrophil-activating peptide 78, receptor for advanced glycation end products, TNF-?, HER2, CXCR4, and leptin. Assays of these factors, or subsets thereof, provide a pro-inflammatory cytokine score useful in determining a characteristic of the cancer, particularly aggressiveness.

Abstract: The present invention relates to compositions and methods for the treatment of a canine CD20 positive disease or condition using a canine CD20-specific chimeric antigen receptor. One aspect includes a modified canine T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity in canine.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: A computer-implemented method includes refreshing a set of memory channels in a memory system substantially simultaneously, each memory channel refreshing a rank that is distinct from each of the other ranks being refreshed. Further, the method includes marking a memory channel from the set of memory channels as being unavailable for the rank being refreshed in the memory channel. In one or more examples, the method further includes blocking a fetch command to the memory channel for the rank being refreshed in the memory channel.

Abstract: The invention provides compositions and methods for overcoming poor response to antibody therapy, for example, antibody resistance. The invention also relates to at least one immune receptor (IR) specific to the Fc receptor, vectors comprising the same, and recombinant T cells comprising the Fc immune receptor. The invention also includes methods of administering a modified T cell expressing an immune receptor that comprises a Fc binding domain.

Abstract: One or more memory systems, architectural structures, and/or methods of storing information in memory devices is disclosed to improve the data bandwidth and or to reduce the load on the communications links in a memory system. The system may include one or more memory devices, one or more memory control circuits and one or more data buffer circuits. In one embodiment, the Host only transmits data over its communications link with the data buffer circuit. In one aspect, the memory control circuit does not send a control signal to the data buffer circuits. In one aspect, the memory control circuit and the data buffer circuits each maintain a separate state machine-driven address pointer or local address sequencer, which contains the same tags in the same sequence. In another aspect, a resynchronization method is disclosed.

Abstract: A system, method, and computer program product are provided herein to manage DRAM bank activation per cycle. A memory controller with embedded scheduling logic is employed to manage the system, method, and computer program product and to restrict the quantity of active banks in a given cycle, resulting in power savings with minimal performance loss, if any. The scheduling logic provides instructions to manage the state of associated DRAM banks. Each bank is either in an idle state or an active state, with the idle state consuming less power than the active state. The scheduling logic restricts the quantity of active banks in any cycle, with all other banks being in an idle state, which provides power savings to the associated system.

Abstract: A system and associated processes may perform a memory access operation that includes receiving a data packet comprising a command of a type of a plurality of types of commands. The processes may include initiating a decoding of a first portion of the command, and automatically speculating as to the type of the command. Based on the speculation as to the type of the command, a bank activate command may be generated before the data packet is entirely decoded or received.

Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.