Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4?) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.

Abstract: A device for inhaling an active agent is provided that can be moved from a first configuration to a second configuration. The device comprises two flexible substrates and a membrane located between the two flexible substrates, and the two flexible substrates being connected at two opposing edges and unconnected at two further opposing edges. An active agent provided on the membrane may be inhaled by a user when the device is in the second configuration.

Abstract: A wrist-pose isolation system can infer a wrist pose (e.g., the user's hand position relative to her forearm) and can reduce wrist-induced jitter for projection casting in an XR environment. A user's projection cast can be determined as a combination of a “low-wrist contribution” component (e.g., a body-and-arm component) and a “high-wrist contribution” component (e.g., the pose of the wrist with respect to the arm). Using input from a gesture-tracking system, the contribution of the user's wrist pose to the user's current projection cast is calculated as a “wrist-contribution vector.” A projection cast direction can be determined as the interpolation of the current low-wrist contribution component and the high-wrist contribution component. This interpolation can be performed by weighting each by a specified amount and combining them.

Abstract: A computer-implemented semantic analysis system for ranking search results has instructions including the steps: receive a query about a first document authored by a person; read in data identifying the first document; read in a second document about the person authored after the first document; identify indicator terms in the second document related to whether or not there is a significant discrepancy between the second document and the first document; read in weighting factors for the identified indicator terms; determine an aggregate weighting factor that decreases with an increasing number of indicator terms found; and calculate a score of how much of a discrepancy there is between the second document and the first document using the weighting factors. When multiple first documents are returned for multiple persons, present the links in order from high score to low score.

Abstract: Embodiments of a heating appliance with control features such as knobs can provide tactile feedback to the user during knob operation. Tactile feedback through the knob, e.g., during rotation in one or more directions, can improve control precision. Beneficial control accuracy features, such as can be utilized during appliance operation and setting of parameters of the heating appliance. A user's desired setting, such as various cooking modes or an off position can therefore be input into the heating appliance with tactile control aspects. A user's desired setting can therefore be accurately set, including with the benefit of tactile control aspects.

Abstract: The present disclosure describes a surgical system for a valve in an aorta. The surgical system is configured to serve as a temporary valve and/or filter to facilitate maintenance of proper blood flow while also capturing debris of an excised leaflet as needed.

Abstract: A mount device for receiving a flag pole is described. The mount device is attachable to a trailer hitch such as a gooseneck hitch or a fifth wheel hitch, which is installed on a vehicle. The mount device includes a connecting tube for inserting into a hitch ball receiving aperture of the trailer hitch. The connecting tube has a top end defining a top aperture. The mount device also includes a receiving tube for inserting into the connecting tube. The receiving tube has a top end defining a top aperture for receiving a flag pole by inserting the flag pole into the aperture of the receiving tube.

Abstract: Among other things, the present disclosure relates to re-purposing used lithium-ion batteries. The present disclosure includes treating an electrode using a solvent prior to electrochemically relithiating the electrode. In some embodiments, the relithiation may be done using a roll-to-roll device, wherein the electrode may be secured on a first pin and a second pin, then it may be unwound and submerged in an electrolyte solution. Lithium ions may be inserted into the electrode using a voltage. The layer of lithium may provide lithium ions to the electrode.

Abstract: Provided is a food composition which include a myceliated high-protein food product and methods to make such compositions, which are mixtures of myceliated high-protein food products and other edible materials. A food composition includes dairy alternative products, ready to mix beverages and beverage bases; extruded and extruded/puffed products; sheeted baked goods; meat analogs and extenders; baked goods and baking mixes; granola; and soups/soup bases. Food compositions also include texturized plant protein which can be used for making meat-structured plant protein meat analog or meat extender products. The food compositions have reduced undesirable flavors and reduced undesirable aromas due to use of myceliated high-protein food products as compared to use of similar high-protein material that is not myceliated.

Abstract: An embodiment includes a vascular port comprising: first and second portions that are not monolithic with each other; wherein: (a)(i) the first portion includes a first arcuate surface to contour to a first portion of a vessel and the second portion includes a second arcuate surface to contour to a second portion of the vessel; (a)(ii) the first and second portions couple to one another around the vessel when implanted to form a central chamber that houses the vessel; (a)(iii) the first portion includes a port that includes a funnel with a funnel surface that narrows as the funnel surface approaches the central chamber; (a)(iv) the central chamber includes a central longitudinal axis and the funnel includes a central vertical axis that is orthogonal to the longitudinal axis; (a)(v) the second portion includes a hardened, non-compliant surface that intersects the vertical axis.

Abstract: Various systems and methods are described to enable cyber-physical protections in edge computing platforms, including with countermeasures that mitigate and halt a variety of digital or real-world attacks. In an example, an attack detection and response engine is used to monitor processing circuitry, with operations that: identify operational data from processing circuitry that operates multiple layers (e.g., of an IP block) to perform compute operations, with trust of the processing circuitry established based on attestation of a hardware root of trust (RoT); evaluate the operational data to identify an attack condition at the processing circuitry, based on monitoring an operational layer of the multiple layers; and provide a digital attack response to the processing circuitry, in response to identifying the attack condition, to deploy the digital attack response and cause a countermeasure at the operational layer of the processing circuitry.

Abstract: An aqueous biopolymer dispersion composition comprises: a blend of two or more biopolymers, consisting of polycaprolactone (PLC) and one or more selected from the group consisting of: polybutylene adipate terephthalate (PBAT), polybutylene succinate (PBS), polybutylene succinate adipate (PBSA), polylactic acid (PLA), poly(3-hydroxybutyrate) (PHB) and mixtures thereof, a stabilising agent selected from the group consisting of: polyvinyl alcohol, fatty alcohol ethoxylates, ethylene oxide/propylene oxide (EO/PO) block copolymers, salts of fatty acids and mixtures thereof, a cross linking agent; an optional rheology modifier; optional further ingredients; and water.

Abstract: A cooking appliance includes an oven body having an interior compartment and a door panel for accessing the interior compartment, wherein the interior compartment is sized to receive a food product; a removable heated tray positionable within the interior compartment, wherein the heated tray includes a top tray surface and a first heating source positioned below the top tray surface; and a second heating source positioned within the interior compartment.

Abstract: An apparatus and system for monitoring and treating cataracts, the apparatus comprising: a monitoring light source configured to monitor cataracts by emitting monitoring light in the wavelength range of 350 to 410 nm to excite fluorescence light in the cataracts, a treating light source configured to treat cataracts by emitting treating light in the wavelength range of 400 to 570 nm to irradiate the cataracts, a wavelength selection system configured to monitor cataracts by selecting wavelengths of the excited fluorescence light in the cataracts and a dichroic beam splitter configured to reflect the monitoring light and the treating light towards the cataracts and the excited fluorescence light in the cataracts towards the wavelength selection system, wherein the monitoring light, the treating light and the excited fluorescence light are reflected by the dichroic beam splitter along a common optical axis and wherein the dichroic beam splitter is arranged at 45 degrees to the common optical axis to transmit wa

Abstract: A motion simulation apparatus includes a motion platform. A carrier for carrying a user is mounted on the motion platform. The apparatus has a drive arm with a lower end that is pivotally mounted on a substrate to pivot relative to the substrate with two degrees of freedom of movement and an upper end that is pivotally connected to the motion platform to pivot with respect to the motion platform with two degrees of freedom of movement. The apparatus has two guide arms, each guide arm having a lower end that is pivotally mounted on the substrate to pivot relative to the substrate with three degrees of freedom of movement and an upper end that is pivotally connected to the motion platform to pivot relative to the motion platform with three degrees of freedom of movement. The drive arm, the guide arms and the motion platform define a dynamic frame that can pivot with respect to the substrate such that a resultant movement of the motion platform can be imparted to the carrier.

Abstract: A method includes receiving raw data and generating a manufacturing data packet (MDP) that includes at least a portion of the raw data. Generating the MDP includes associating metadata with the raw data and associating a timestamp with the raw data. The timestamp is synchronized to a common reference time. A data model associated with the MDP is obtained. The data model includes one or more predefined data types and one or more predefined data fields. A first data type from the one or more predefined data types is determined based at least in part on characteristics of the raw data. An algorithm is determined based at least in part on the first data type. The MDP is processed according to the algorithm to produce an output. The first data type is associated with the raw data. The output is associated with a data field of the first data type.

Abstract: A phased array ultrasonic testing device for positioning first and second phased array probes relative to a surface of a material to be tested. The testing device includes a first wedge configured to receive and orient the first phased array probe relative to the surface. A second wedge is configured to receive and orient the second phased array probe relative to the surface. A coupling structure is mounted to the first and second wedges and configured to selectively provide for the first and second wedges to move parallel to one another in a first direction and restrict relative movement of the first and second wedges in other directions.

Abstract: The present invention relates to a polyester resin for extrusion blow molded bottles comprising a branched aliphatic glycol and a branching comonomer.

Abstract: Among other things, the present disclosure relates to re-purposing used lithium-ion batteries. The present disclosure includes treating an electrode using a solvent prior to electrochemically relithiating the electrode. In some embodiments, the relithiation may be done using a roll-to-roll device, wherein the electrode may be secured on a first pin and a second pin, then it may be unwound and submerged in an electrolyte solution. Lithium ions may be inserted into the electrode using a voltage. The layer of lithium may provide lithium ions to the electrode.

Abstract: An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can exhibit biphasic or sustained kinetics of release with an immediate portion released rapidly and an extended portion released in a prolonged manner when exposed to a dissolution medium. The prolonged aversive agent release provides deterrence against extraction of drug from fresh and used patches and serves to prevent accidental misuse of used patches by children. The abuse deterrent and misuse deterrent patch systems can be used for transdermal delivery of therapeutically active agents and particularly those drugs that are highly prone to abuse such as opiate and opioid analgesics and stimulants.