Abstract: The invention relates to an orthosis for a lower limb, with a foot part, which has a sole for supporting a foot, and with at least one leg rail, which extends from the foot part and, in the fitted state, extends along a lower leg and has devices for supporting and/or securing the leg rail on the lower leg, wherein the orthosis is assigned at least one sensor for detecting orthosis parameters, which sensor is coupled to a control device, and the foot part is assigned at least one device coupled to the control device and/or materials for changing the stiffness of the sole.

Abstract: Provided is a document cancellation engine that can interact with document management systems and assist in identifying document cancellation actions that are available for an electronic document that has already been submitted. In one example, a method may include receiving an identification of an electronic document from an application, identifying a document type of the electronic document and a jurisdiction where the electronic document has been submitted, determining whether available cancellation actions exist for the electronic document based on the identified jurisdiction and document type, and in response to a determination that available cancellation actions exist, outputting information about the available cancellation actions to the application.

Abstract: The present invention relates to compositions comprising galactooligosaccharides (GOS) and probiotic bacteria obtained by a process comprising the step of growing the bacteria in a medium comprising GOS, such composition having the effect of boosting the synbiotic effect of the probiotic bacteria with the GOS. Health benefits of the probiotic bacteria as obtained by such a fermentation process are also contemplated.

Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.

Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. The present invention also discloses intermediates which are useful in the preparation of these compounds.

Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.

Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.

Abstract: An adjusting device for adjustably securing at least two orthotic components to each other. The adjusting device includes a first holder which has a first fastening element for securing a first orthotic component, and a second holder which has a second fastening element for securing to a second orthotic component. The holders are mounted such that they can be moved in relation to each other and secured to each other in at least two orientations.

Abstract: The inventive waveguide structure comprises a first waveguide region having a constant first width adapted to guide electromagnetic waves mode sustainably along its longitudinal axis; a second waveguide region adapted to guide electromagnetic waves mode sustainably along its longitudinal axis, wherein the longitudinal axis of the first waveguide region and the longitudinal axis of the second waveguide region form a common longitudinal axis of the waveguide structure, wherein a first end face of the first waveguide region and a first end face of the second waveguide region are aligned with each other, the width of the first end face of the second waveguide region corresponding to the first width, and the width of the second waveguide region along its longitudinal axis widens from the first end face to a second end face to a second width greater than the first width.

Abstract: A joint for an orthopedic device, wherein the joint comprises a first element, at least one elastic element on a support, which is assembled on the first element, and a second element, which is pivotally assembled on the first element and can be swivelled in a direction between the first element and the second element, starting from a first angle of engagement, against a force applied by the at least one elastic element wherein the support comprises a contact element which rests against the second element upon reaching the first angle of engagement, wherein the contact element can be adjusted when the joint is assembled such that the first angle of engagement and a preload of the elastic element can be adjusted independently of one another.

Abstract: A composition includes at least one carrier containing a polysaccharide, at least one antioxidant and at least one amino acid selected from cysteine, lysine, alanine and arginine. Such a composition can be used for protection of microorganisms during drying, storage and/or reconstitution. A culture powder, a process of making the culture powder, and products containing the culture powder are also disclosed.

Abstract: The present invention relates to a composition comprising at least one carrier comprising a polysaccharide, at least one antioxidant and at least one amino acid selected from cysteine, lysine, alanine and arginine. It also relates to the use of such a composition for the protection of microorganisms during drying, storage and/or reconstitution, to a culture powder, to a process of making the culture powder and to products comprising the culture powder.

Abstract: Systems and methods for applying machine learning to dynamically validate a sales transaction document created by a user in a computing system are provided. Data comprising the sales transaction document is received. A machine learning model is applied to the sales transaction document to verify that the sales transaction document meets at least one compliance standard. The user is alerted if the sales transaction document does not meet the at least one compliance standard. The maching learning model is generated by: receiving first sales transaction data from a database; determining patterns based on the first sales transaction data, wherein the patterns indicate that corrective data was created to compensate for at least one error in original data, the at least one error indicating that the original data did not meet at least one compliance standard; and generating the machine learning model based on the determined patterns.

Abstract: A prosthetic liner for application on a stump, the prosthetic liner including an elastic base, which has a proximal opening for insertion of the stump a receiving space, and a distal end. At least one pneumatic piston is arranged on the outer face of the prosthetic liner.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: A prosthetic liner for application on a stump, comprising an elastic base, which has a proximal opening for insertion of the stump in a receiving space, and a distal end. At least one pneumatic piston is arranged on the outer face of the prosthetic liner.

Abstract: An orthopedic joint device having a lower leg part, a foot part that is arranged on the lower leg part about a swivel axis such that it can be swivelled, at least a first energy store, and a coupling element. The coupling element can be brought into a coupling position, in which a swivelling of the foot part relative to the lower leg part about the swivel axis in a plantar flexion direction leads to an increase in the amount of energy stored in the first energy store, and a de-coupling position. The orthopedic joint device also has at least one release element, which can be brought into a release position and a locked position. The energy stored in the first energy store can be released by bringing the release element into the release position.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: Systems and methods for applying machine learning to dynamically validate a sales transaction document created by a user in a computing system are provided. Data comprising the sales transaction document is received. A machine learning model is applied to the sales transaction document to verify that the sales transaction document meets at least one compliance standard. The user is alerted if the sales transaction document does not meet the at least one compliance standard. The maching learning model is generated by: receiving first sales transaction data from a database; determining patterns based on the first sales transaction data, wherein the patterns indicate that corrective data was created to compensate for at least one error in original data, the at least one error indicating that the original data did not meet at least one compliance standard; and generating the machine learning model based on the determined patterns.

Abstract: The inventive waveguide structure comprises a first waveguide region having a constant first width adapted to guide electromagnetic waves mode sustainably along its longitudinal axis; a second waveguide region adapted to guide electromagnetic waves mode sustainably along its longitudinal axis, wherein the longitudinal axis of the first waveguide region and the longitudinal axis of the second waveguide region form a common longitudinal axis of the waveguide structure, wherein a first end face of the first waveguide region and a first end face of the second waveguide region are aligned with each other, the width of the first end face of the second waveguide region corresponding to the first width, and the width of the second waveguide region along its longitudinal axis widens from the first end face to a second end face to a second width greater than the first width.