Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

Abstract: In a general aspect, a quantum logic gate is performed in a quantum computing system. In some cases, a pair of qubits are defined in a quantum processor; the pair of qubits can include a first qubit defined by a first qubit device in the quantum processor and a second qubit defined by a tunable qubit device in the quantum processor. A quantum logic gate can be applied to the pair of qubits by communicating a control signal to a control line coupled to the tunable qubit device. The control signal can be configured to modulate a transition frequency of the tunable qubit device at a modulation frequency, and the modulation frequency can be determined based on a transition frequency of the first qubit device.

Abstract: Measures for providing timer services in a network including a cluster of nodes responsible for providing timer services to clients. At a given node in the cluster, a request to provide a timer is received from a client. Configuration of a primary replica of the requested timer on a first node in the cluster to pop after a first time has elapsed is initiated. A first timer replication message is transmitted to a second node in the cluster, the first timer replication message indicating that the second node should configure a first backup replica of the requested timer. A second timer replication message is transmitted to a third node in the cluster, the second timer replication message indicating that the third node should configure a second backup replica of the requested timer. Popping of the primary, first backup or second backup timer replicas includes initiating callback of a given client.

Abstract: A reaction system comprises a reactor vessel, a secondary vessel, a transfer line providing fluid communication between the reactor vessel and the secondary vessel, a return line providing fluid communication between the secondary vessel and the reactor vessel, a filter disposed within the secondary vessel, and at least one freeze plug valve disposed within the transfer line or the return line.

Abstract: A heat transfer media comprises a particle. The particle comprises a discontinuous phase and a matrix material. The discontinuous phase is disposed within the matrix material, and the matrix material has a higher melting point than the discontinuous phase. The discontinuous phase has a melting point selected to be within a reaction temperature range.

Abstract: A reaction process includes introducing hydrocarbon reactants into a vessel, reacting the hydrocarbon reactants in contact with the gas phase catalyst in the vessel to produce reaction products comprising solid carbon and a gas phase product, separating the solid carbon from the gas phase products and the gas phase catalyst to produce a solid carbon product, condensing the gas phase catalyst to produce a condensed catalyst, and returning the condensed catalyst to the liquid catalyst reservoir. The vessel comprises a gas phase catalyst and a liquid catalyst reservoir containing a liquid catalyst.

Abstract: A pyrolysis process comprises introducing one or more chemical reactants into a reactor containing a liquid maintained at a high temperature, producing chemical products in the liquid based on the high temperature, allowing the solid product to grow in particle size, accumulating the solid product in the liquid, and removing the solid product from the reactor while retaining a substantial portion of the liquid within the reactor. The chemical products comprise a solid chemical product that is mixed with the liquid.

Abstract: A media gateway and method with a media session manager function, a media processor function, and a media session state datastore function. The functions are provided by one or more instantiations which allow for independent scalability of the functions in the media gateway.

Abstract: Measures for providing timer services in a network including a cluster of nodes responsible for providing timer services to clients. At a given node in the cluster, a request to provide a timer is received from a client. Configuration of a primary replica of the requested timer on a first node in the cluster to pop after a first time has elapsed is initiated. A first timer replication message is transmitted to a second node in the cluster, the first timer replication message indicating that the second node should configure a first backup replica of the requested timer. A second timer replication message is transmitted to a third node in the cluster, the second timer replication message indicating that the third node should configure a second backup replica of the requested timer. Popping of the primary, first backup or second backup timer replicas includes initiating callback of a given client.

Abstract: Measures for providing timer services in a network including a cluster of nodes responsible for providing timer services to clients. At a given node in the cluster, a request to provide a timer is received from a client. Configuration of a primary replica of the requested timer on a first node in the cluster to pop after a first time has elapsed is initiated. A first timer replication message is transmitted to a second node in the cluster, the first timer replication message indicating that the second node should configure a first backup replica of the requested timer. A second timer replication message is transmitted to a third node in the cluster, the second timer replication message indicating that the third node should configure a second backup replica of the requested timer. Popping of the primary, first backup or second backup timer replicas includes initiating callback of a given client.

Abstract: A telephony signalling element and method with a signalling processing function and a session datastore function. The signalling processing function has associated functions that are provided by one or more instantiations, and the session datastore function has associated functions that are provided by one or more instantiations. The instantiations allow for independent scalability of the functions in the telephony signalling element.

Abstract: A media gateway and method with a media session manager function, a media processor function, and a media session state datastore function. The functions are provided by one or more instantiations which allow for independent scalability of the functions in the media gateway.

Abstract: Measures, including methods, systems and computer-readable storage mediums, for use in processing notifications relating to telecommunication sessions. A cluster of servers is operable to receive incoming notifications where each server can process any given notification and update a store holding records based on previous notifications. The cluster may include a timer function to allow records to be closed when no relevant notifications are received after a timeout interval.

Abstract: A media gateway and method with a media session manager function, a media processor function, and a media session state datastore function. The functions are provided by one or more instantiations which allow for independent scalability of the functions in the media gateway.

Abstract: Measures for providing timer services in a network including a cluster of nodes responsible for providing timer services to clients. At a given node in the cluster, a request to provide a timer is received from a client. Configuration of a primary replica of the requested timer on a first node in the cluster to pop after a first time has elapsed is initiated. A first timer replication message is transmitted to a second node in the cluster, the first timer replication message indicating that the second node should configure a first backup replica of the requested timer. A second timer replication message is transmitted to a third node in the cluster, the second timer replication message indicating that the third node should configure a second backup replica of the requested timer. Popping of the primary, first backup or second backup timer replicas includes initiating callback of a given client.

Abstract: Measures, including methods, systems and computer-readable storage mediums, for use in processing notifications relating to telecommunication sessions. A cluster of servers is operable to receive incoming notifications where each server can process any given notification and update a store holding records based on previous notifications. The cluster may include a timer function to allow records to be closed when no relevant notifications are received after a timeout interval.

Abstract: A media gateway and method with a media session manager function, a media processor function, and a media session state datastore function. The functions are provided by one or more instantiations which allow for independent scalability of the functions in the media gateway.

Abstract: A telephony signalling element and method with a signalling processing function and a session datastore function. The signalling processing function has associated functions that are provided by one or more instantiations, and the session datastore function has associated functions that are provided by one or more instantiations. The instantiations allow for independent scalability of the functions in the telephony signalling element.

Abstract: Measures, including methods, systems and computer-readable storage mediums, for use in processing notifications relating to telecommunication sessions. A cluster of servers is operable to receive incoming notifications where each server can process any given notification and update a store holding records based on previous notifications. The cluster may include a timer function to allow records to be closed when no relevant notifications are received after a timeout interval.

Abstract: The present disclosure relates to a process for making an absorbent core comprising a superabsorbent polymer material and an additional particle material.