Abstract: Systems and methods for analyzing biological pathways are described. The techniques describe herein may enable the selection of candidate drugs to be prioritized. The systems and methods described herein provide visualizations for the impact of a drug on a gene signaling pathway. A visualization may be based on gene signaling pathway topology information and a determined gene expression level equivalent value for a drug.

Abstract: Methods, systems, and computer-readable media are provided for synchronizing healthcare data across disparate data centers. Healthcare data from healthcare data sources is received by a collector service that operates in a cloud computing platform. The data is sent to a staging platform associated with a first data center that is hosting the collector service. From here, the data is stored in association with a long-term storage data store associated with the first data center. As well, it is communicated to processing nodes associated with the first data center that subscribe to the data. The staging platform also communicates the data to a staging platform associated with a second data center. This staging platform also stores the data in association with a long-term storage data store located at the second data center and communicates the data to processing nodes located at the second data center that subscribe to the data.

Abstract: Methods, systems, and computer-readable media are provided for aggregating, partitioning, and storing healthcare data. Healthcare data is collected from various disparate healthcare data sources. The data is aggregated into batches of the same type of data. From here, the data is partitioned according to the data's originating healthcare data source. The aggregated and partitioned healthcare data is then stored in a long term storage data store. This system of storing healthcare data allows for efficient retrieval and processing by computing solutions that need access to batches of healthcare data. The system also reduces costs associated with storing data as duplicate storage is eliminated.

Abstract: The present disclosure is directed to a novel way to attach various accessories to the temple vents of protective eyewear. In one aspect of the disclosure; a clip with a male key portion is configured to attach accessories by rotationally locking the clip into a vent of a temple of a pair of protective eyewear, with the accessories attached to the clip.

Abstract: An adjustable apparatus for guiding medical instruments used in attaching bone plates. The apparatus has a handle assembly, guide member, a spacer, and an actuation member. The actuation member extends from the handle assembly and actuates the spacer between a position adjacent the guide member and a position spaced from the guide member. The spacer has a through hole that may axially align with a lumen extending through the guide member when in the first position and which is moved out of axial alignment with the lumen in the second position. The spacer may function as a depth stop to control the maximum depth a drill bit can extend from the guide member.

Abstract: A system and method that integrates a plurality of media service systems offering different multimedia services such as media storage, syndication, delivery, and billing services. The system and method also provides automated file transcoding. In embodiment, a method of the present invention includes receiving a plurality of physical media files, organizing the plurality of physical media files so that different bit-rates and formats of a single source material are organized into a media database entity, receiving user specified delivery settings for the distribution of the physical media file, generating a release database entity storing the delivery settings of the physical media file, generating an address indicating the storage location of the release, and transmitting the address to a remote computing device.

Abstract: A system and method that integrates a plurality of media service systems offering different multimedia services such as media storage, syndication, delivery, and billing services. The system and method also provides automated file transcoding. In embodiment, a method of the present invention includes receiving a plurality of physical media files, organizing the plurality of physical media files so that different bit-rates and formats of a single source material are organized into a media database entity, receiving user specified delivery settings for the distribution of the physical media file, generating a release database entity storing the delivery settings of the physical media file, generating an address indicating the storage location of the release, and transmitting the address to a remote computing device.

Abstract: Disclosed are knee pad assemblies, methods and systems comprising a knee pad base and an outer cover that forms the contacting surface of the knee pad. A removable cover may be secured to a knee pad base. Replacement cover configurations may be provided that are adapted to various surfaces, including roofing, tile, wood, carpet, concrete and asphalt. The knee pad base can be adapted for different user weights and durations for wearing the pad. The outer cover can provide a floating suspension. The knee pad base may be held in place on knee of the user by various mechanisms. The restraint mechanisms can be adjusted by the user. The knee pad assembly can also include a tension/release mechanism so that strap tension is decreased or released when kneeling but increases tension or engage when the user stands to retain the knee pad in the desired location.

Abstract: A modular lighted floor mat for use beneath equipment for providing hands-free light necessary to work on the equipment. The modular lighted floor mat for use beneath equipment includes a lighted floor mat assembly including a base member, light-emitting members, and a transparent load-bearing cover being disposed over the light-emitting members and the base member and being capable of withstanding substantial weights and also being impervious to chemicals.

Abstract: Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.

Abstract: Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.

Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.