Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: RQ-POLY-Xr-TLR7/8 AG)q??Formula I or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist.

Abstract: The invention provides a lighting fixture based on a DMX controller, and a control method. The lighting fixture includes an NFC address writer, a DMX controller for outputting light control data, NFC controllers receiving data from the DMX controller, and DMX lamps receiving data from the NFC controllers, wherein the DMX controller, the NFC controllers and the DMX lamps are electrically connected in sequence, the NFC address writer is used for modifying address information of the NFC controllers in real time, the NFC controllers selectively extract the light control data output by the DMX controller according to the address information and output the extracted light control data to the DMX lamps, and the DMX lamps change light according to the light control data received from the NFC controllers.

Abstract: An automatic biological sample library, includes a frame, an upper computer, a control system, a liquid nitrogen tank, an insulated chamber, a transfer container, a rotary-disk rotating module, a basket lifting module, a tray shoveling module, a tube picking module and a transfer module. The rotary-disk rotating module, the basket lifting module, the tray shoveling module, the tube picking module and the transfer module are electrically connected to the control system.

Abstract: This application discloses a communication method and apparatus, which belong to the communication field and are used for data frame transmission. The method is applied to a transit node of a communication system, and the method includes: receiving a data frame, where the data frame includes a bandwidth exclusive channel number, and the data frame is an optical transport network data frame or a microwave data frame; when the bandwidth exclusive channel number carried in the data frame is a preset bandwidth exclusive channel number, obtaining scheduling information and a sink node address from the data frame; and scheduling the data frame based on the scheduling information, and forwarding the data frame to a sink node indicated by the sink node address. In this application, bandwidth utilization of the bandwidth exclusive channel is improved.

Abstract: A method of forming a structure having a coating layer includes the following steps: providing a substrate; coating a fluid on the surface of the substrate, where the fluid includes a carrier and a plurality of silicon-containing nanoparticles; and performing a heating process to remove the carrier and convert the silicon-containing nanoparticles into a silicon-containing layer, a silicide layer, or a stack layer including the silicide layer and the silicon-containing layer.

Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

Abstract: A microelectrode sensor for detecting Staphylococcus aureus and a preparation method and an application method thereof are provided. The microelectrode sensor is a three-electrode system sensor with a platinum wire electrode as a counter electrode and an Ag/AgCl electrode as a reference electrode, and a working electrode is a silver microelectrode modified by chitosan, catechol and Staphylococcus aureus aptamers. The microelectrode sensor is constructed based on the microelectrode with micro/nano structure on the surface, dual media (Fc-Ru3+), chitosan, and catechol. The working electrode can specifically capture Staphylococcus aureus. During the CV test of the microelectrode sensor, the Cl? in bacteria will be leaked to a surface of the working electrode under the action of local high-field strength, and when Cl? ions exists, the cathodic reduction peak of the working electrode can be specifically enhanced between 0 to ?0.1 V, the goal of specific detection of bacteria can be achieved.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: Provided are a nucleic acid library construction method and an application thereof in the analysis of an abnormal chromosomal structure of a preimplantation embryo. Enzymatic cleavage is performed by means of combining a first endonuclease and a second endonuclease to capture a DNA sequence within a fixed fragment range. The specific sequences captured are then sequenced. When the average genome sequencing depth is greater than or equal to 3×, an SNP analysis can be performed in the entire range of the genome in order to perform detection of balanced translocation of the embryo and the like by means of a linkage analysis of a family-line sample.

Abstract: A compound as a potassium channel regulator and preparation and use thereof are described. Specifically, the compound has the structure shown in formula A. A preparation method of the compound and its use as a potassium channel regulator in a medicament and a pharmaceutical composition are also described.

Abstract: A puncture needle assembly (1000) and a puncture system (100) are provided. The puncture needle assembly (1000) includes a needle holder (1100) and a needle (1200). The needle holder (1100) comprises a channel axially extending therethrough. The channel has a sidewall, at least a part of which is provided by a conductor (1110). The needle (1200) has a proximal end portion extending in the channel and electrically connected to the conductor (1110). The puncture system (100) includes the puncture needle assembly (1000) and a dilator (2000). The dilator (2000) includes a dilation catheter (2100) and an optional conductive biasing member (2200) disposed on the dilation catheter (2100). Even when a distal end of the needle (1200) is hidden in the dilation catheter (2100), the conductive biasing member (2200) can still establish an electrical connection between the needle and the blood outside thereof.

Abstract: The present invention provides aqueous in-situ gel ophthalmic formulations, each including water, difluprednate and a biocompatible polysaccharide, wherein a gel is formed in situ at physiological temperature with instant viscosity increase upon instillation of the formulation into an eye. In the formulations, nanocarriers may be formed by a surfactant or solubilizer contained in the formulation, with or encapsulating difluprednate, and the nanocarriers have an average particle size of 10 to 500 nm or 10 to 150 nm or 10- to 50 nm.

Abstract: A strain gauge (10, 40, 50), a pressure sensor (20, 60), and an interventional medical catheter. The strain gauge (10, 40, 50) comprises a substrate (11) and at least two sensitive gages (1, 2) provided on the substrate (11), the at least two sensitive gages (1, 2) being arranged along two mutually perpendicular directions and sharing one ground port (3). The pressure sensor (20, 60) comprises an elastic body (21, 61) and the strain gauge (10, 40, 50) provided on the elastic body (21, 61). The interventional medical catheter comprises a catheter distal end and the pressure sensor (20, 60) provided at the catheter distal end.

Abstract: A microwave data processing method, apparatus, and a device. A logical slice is obtained by slicing a microwave data stream, and an independent air interface resource is allocated to the logical slice, so that different logical slices are independent of each other, and then different logical slices are correspondingly encoded, so that encoded data that meets different transmission conditions is generated for different types of logical slices, thereby improving reliability of microwave data transmission, and increasing application scenarios of microwave data transmission.

Abstract: The present invention provides aqueous formulations containing povidone iodine to be topically applied into a body cavity such as nose of a subject. The formulations of this invention are useful for treating a disease or symptom related to or caused by infection of COVID-19 virus or influenza virus H1N1.

Abstract: The present invention provides aqueous ophthalmic formulations containing 0.01%-5% by weight of cyclosporine which exists in the form of micelles having a particle size not greater than 20 nm, and methods of making and using such formulations.

Abstract: The value for equipment to be replaced can be maximized by determining a threshold cutoff value for a failure prediction indicator and a window size for obtaining the threshold cutoff value for a piece of oil or gas drilling or recovery equipment; applying the threshold cutoff value and the window size to an equipment failure prediction model; and deriving a recall value and an average hour-loss value from the equipment failure prediction model. Predictive maintenance for the piece of oil or gas drilling or recovery equipment may be performed based on the recall value and the average hour-loss value to perform predictive maintenance for a piece of equipment in an oil or gas recovery operation.