Abstract: A tetrahydroisoquinoline compound as a potassium channel modulator and preparation and application thereof. Specifically, the compound has the structure as shown in formula A.

Abstract: A strain gauge (10, 40, 50), a pressure sensor (20, 60), and an interventional medical catheter. The strain gauge (10, 40, 50) comprises a substrate (11) and at least two sensitive gages (1, 2) provided on the substrate (11), the at least two sensitive gages (1, 2) being arranged along two mutually perpendicular directions and sharing one ground port (3). The pressure sensor (20, 60) comprises an elastomer (21, 61) and the strain gauge (10, 40, 50) provided on the elastomer (21, 61). The interventional medical catheter comprises a catheter distal end and the pressure sensor (20, 60) provided at the catheter distal end.

Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

Abstract: Disclosed are a compound having a neuroprotective effect, a preparation method therefor and a use thereof. Specifically, the compound has the structure shown by formula I, the definition of each group and substituent being as described in the description. Further disclosed are a preparation method for the compound and a use thereof for neuroprotection.

Abstract: A method, apparatus and system for processing a live broadcast information stream are provided. The method includes: obtaining an encryption permission recognition result by recognizing an encryption permission for a target live broadcast room in response to a live broadcast request of the target live broadcast room sent by an anchor client; generating an encryption live broadcast indication and a stream pushing address of the target live broadcast room in response to the encryption permission recognition result indicating that the target live broadcast room is an encrypted live broadcast room, in which the encryption live broadcast indication is used to instruct a live broadcast source station to encrypt live broadcast information stream of the target live broadcast room; and sending the stream pushing address corresponding to the target live broadcast room to the anchor client, in which the stream pushing address indicates an address of the live broadcast source station.

Abstract: The present invention provides aqueous formulations containing an anti-infection agent, a biocompatible polysaccharide, an osmotic pressure regulator, a pH regulator, and water, wherein a gel containing the therapeutic agent is formed in situ upon instillation of the formulations onto the skin and a body cavity of a subject. The formulations of this invention are useful for treating infectious diseases of skin or a body cavity (e.g., eye, nose, or vagina) of a subject.

Abstract: A method for detecting the quality of cell culture fluid based on Raman spectral measurement. The method comprises the following steps: collecting cell culture fluid; collecting, processing and analyzing a Raman spectral signal; measuring an original Raman spectral signal of a metabolite in the cell culture fluid using a Raman spectra technique; determining whether the original Raman spectral signal is qualified, and carrying out data signal processing on the qualified original Raman spectral signal to obtain analyzable signals; and then carrying out difference statistical analysis on the analyzable signals to obtain difference signals; carrying out modeling using the difference signals; classifying the difference signals using a support vector machine; and distinguishing the spectral signals of normal and abnormal cell culture fluid to obtain a quality result of the cell culture fluid.

Abstract: The present invention provides pharmaceutical compositions comprising an antiseptic and a steroid, useful for treating a clinical symptom in a patient's airway (e.g., nose, lung, and sinus), wherein a gel containing the antiseptic is formed in situ upon instillation of the compositions onto a body cavity of a subject, as well as methods for using the same.

Abstract: A strain gauge includes: a substrate; a transverse sensitive grid arranged on the substrate; and at least two non-transverse sensitive grids arranged on the substrate so as to be located on opposite sides of the transverse sensitive grid both electrically connected to the transverse sensitive grid. The two non-transverse sensitive grids are connected to each other by a connection and share a common ground lead and a common ground interface. One end of the ground lead is connected to the connection at the middle thereof. The other end of the ground lead is connected to the ground interface. The two non-transverse sensitive grids have equal resistances and are connected to ends of two respective non-ground leads having equal resistances. The other ends of the two non-ground leads are connected to two respective non-ground interfaces.

Abstract: Provided a vitrification freezing carrier includes a tube body of a hollow structure with an opened end provided with a matching part, a tube cap provided with a covering part of a hollow structure with one end closed and matching the matching part and provided with an extending part connected to the covering part, a carrying rod arranged on a side, facing an interior of the tube body, of the covering part and capable of extending into the tube body, and an auxiliary sampling mechanism including a carrier body provided with a locking part configured to be matched with the covering part to drive the covering part to move and an elastic reset assembly arranged on the carrier body and including a driving part and an elastic part driven by the driving part and capable of being selectively connected to the extending part in a matched manner.

Abstract: A method of forming a structure having a coating layer includes the following steps: providing a substrate; coating a fluid on the surface of the substrate, where the fluid includes a carrier and a plurality of silicon-containing nanoparticles; and performing a heating process to remove the carrier and convert the silicon-containing nanoparticles into a silicon-containing layer, a silicide layer, or a stack layer including the silicide layer and the silicon-containing layer.

Abstract: Disclosed is a design reference value quantification method for a modifier dosage of modified asphalt. A curve of unsaturation degree of the modified asphalt as a function of the modifier dosage is plotted, in which the unsaturation degree of a series of modified asphalts is determined by potentiometric titration; further, an inflection point of the unsaturation degree of the modified asphalt as a function of the modifier dosage in the asphalt is obtained by data fitting and analysis, and a reference value of the dosage of the modifier added in the process design of the modified asphalt is established.

Abstract: 2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof are provided. Specifically, the 2-aminopyrimidine compounds have a structure as shown in formula I. The compounds are suitable for use in the fields of anti-virus and anti-infection, as well as treatment of diseases such as autoimmune diseases and tumors.

Abstract: The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and/or post-surgical operations.

Abstract: A soft joint gripper based on 4D printing comprises a palm body and five soft finger units connected with the palm body; each soft finger unit is provided with two soft finger joints and two finger bones; the finger bones are made of 3D printing resin; the soft finger joints are two symmetrical double-layer thin-film soft finger joint actuators; the double-layer thin-film soft finger joint actuator is made of a 4D printing liquid crystal elastomer and a polyimide electrothermal film, and the bending angle of each double-layer thin-film soft finger joint actuator is changed by energization or heating stimulation; and the double-layer film soft finger joint actuator is used to control the soft finger unit to perform reversible bending motion. Accurate control of the soft joint gripper can be realized.

Abstract: The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.

Abstract: Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing Respiratory Syncytial Virus (RSV) G protein or a recombinant RSV G protein, as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the RSV G protein or the recombinant RSV G protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to RSV and HPIV3 in a subject.