Abstract: Apparatus and methods for determining operational health of a pump. An example method may include commencing operation of a processing device to monitor operational health of a pump for pumping a fluid at a wellsite, wherein the pump may be a reciprocating pump. During pumping operations of the pump, the processing device may receive pressure measurements of the fluid at a fluid inlet manifold and/or a fluid outlet manifold of the pump, receive position measurements of fluid displacing members of the pump, detect irregular pressure measurements based on the received pressure measurements, determine operational phase of the pump based on the received position measurements, and determine which of fluid inlet and outlet valves of the pump is leaking based on operational phase during which the irregular pressure measurements are detected.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: An exemplary electrified vehicle assembly includes a cable connected to an electrified vehicle battery. The cable has a coiled portion providing an inductor.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: A product returns processing system may include mobile devices communicating respective purchase transaction receipts for respective products. The system may also include a returns processing server including a processor and a memory. The memory may store the purchase transaction receipts, for each product, a product return rule, a product availability status, and a disposition, and for each user, a return mode preference. The processor may determine a return expiration for each product based upon a respective product return rule, send a notice to each mobile device based upon a respective return window expiration, and receive a return request. The processor may, when the request is received before a return expiration, determine a product availability and condition, determine a return address based upon the disposition and at least one of the product availability and condition, and generate a label with the return address and based upon the return mode preference.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for ex ample through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: A system for tax tracking of blended goods may include a value tracking server configured to, at a time of sale of an item including materials blended together, collect relative material quantities in the item, each of the materials having different respective tax rates associated therewith, and generate an identification (ID) for association with the item. The value tracking server may also be configured to, at a time of return, read the ID from the item to determine the relative material quantities in the item, determine a returned portion of the item, and determine a tax refund due based upon the relative material quantities, the respective tax rates, and the returned portion of the item.

Abstract: A laundry treating appliance, such as a clothes washer, either vertical or horizontal axis, can have a bulk dispenser capable of dispensing multiple doses of treating chemistry from a reservoir of treating chemistry. A housing fluidly couples a supply of water and the treating chemistry for supplying both to a treating chamber within the laundry treating appliance.

Abstract: A power system comprises a converter including an inductor core defining a gap, and a separator spanning the gap and contacting the core. The power system also includes a controller programmed to, responsive to a decrease in current ripple amplitude output by the converter to less than a first threshold, decrease power supplied by the converter. The first threshold is indicative of an inductance change through the core due to a temperature driven decrease in size of the separator.

Abstract: A laundry treating appliance, such as a clothes washer, either vertical or horizontal axis, can have a bulk dispenser capable of dispensing multiple doses of treating chemistry from a reservoir of treating chemistry. A housing fluidly couples a supply of water and the treating chemistry for supplying both to a treating chamber within the laundry treating appliance.

Abstract: A pharmaceutical transport system may include a pneumatic tube network and a pharmaceutical transport container movable within the pneumatic tube network. The pharmaceutical transport container may include a tubular container having open and closed positions for receiving at least one pharmaceutical therein, and an electronic lock securing the tubular container in the closed position and opening based upon a match between an entered digital code and a current changing digital code.

Abstract: Apparatus and methods for determining operational health of a pump. An example method may include commencing operation of a processing device to monitor operational health of a pump for pumping a fluid at a wellsite, wherein the pump may be a reciprocating pump. During pumping operations of the pump, the processing device may receive pressure measurements of the fluid at a fluid inlet manifold and/or a fluid outlet manifold of the pump, receive position measurements of fluid displacing members of the pump, detect irregular pressure measurements based on the received pressure measurements, determine operational phase of the pump based on the received position measurements, and determine which of fluid inlet and outlet valves of the pump is leaking based on operational phase during which the irregular pressure measurements are detected.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for ex ample through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: A system for tax tracking of blended goods may include a value tracking server configured to, at a time of sale of an item including materials blended together, collect relative material quantities in the item, each of the materials having different respective tax rates associated therewith, and generate an identification (ID) for association with the item. The value tracking server may also be configured to, at a time of return, read the ID from the item to determine the relative material quantities in the item, determine a returned portion of the item, and determine a tax refund due based upon the relative material quantities, the respective tax rates, and the returned portion of the item.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: An example apparatus for generating real-time director's cuts includes a number of cameras to capture videos of a plurality of participants in a scene. The apparatus also includes a number of microphones to capture audio corresponding to each of the number of participants. The apparatus further includes a role-centric evaluator to receive views-of-participants and a role for each of the participants and rank the views-of-participants based on the roles. Each of the views-of-participants are tagged with one of the participants. The apparatus further includes a view broadcaster to display a highest ranking view-of-participant stream.

Abstract: A semiconductor assembly includes a power semiconductor, a housing containing the power semiconductor, and electrically conductive channels. The electrically conductive channels are arranged to direct coolant through the housing. Heat generated by the power semiconductor can therefore be absorbed by the coolant. The electrically conductive channels are also electrically connected with the power semiconductor to form terminals for the power semiconductor.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.