Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: Apparatus, method, and a containment system for a mud tank. The system includes a pan extending from a base of the mud tank and configured to receive fluids leaked therefrom, a fluid sensor coupled with the pan, and a pump in fluid communication with the pan, wherein the pump is configured to remove fluid from the pan when the fluid sensor reads a predetermined threshold fluid level in the pan.

Abstract: A silo, a chemical delivery system, and a method. The silo includes a housing and a vessel positioned within the housing and configured to contain a mud chemical. The vessel includes a discharge port and a discharge valve that controls discharge of the mud chemical through the discharge port. The discharge port is configured to connect to a skid by placing the silo on the skid, and the silo has a plurality of configurations for different types of mud chemicals.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: Apparatus, method, and a containment system for a mud tank The system includes a pan extending from a base of the mud tank and configured to receive fluids leaked therefrom, a fluid sensor coupled with the pan, and a pump in fluid communication with the pan, wherein the pump is configured to remove fluid from the pan when the fluid sensor reads a predetermined threshold fluid level in the pan.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: An electronic circuit system with an input for receiving an analog signal having a frequency and comprising noise, that noise including input referred noise, and the noise fluctuates in a range. The system also comprises a signal path with: (i) an analog to digital converter for providing a digital output value in response to a clock period; (ii) a feedback node; and (iii) circuitry for limiting a signal swing at the feedback node, during a period of the clock period, to be no greater than an RMS value of the noise. The analog to digital converter is further for providing the digital output value in response to the analog signal and the signal swing at the feedback node.

Abstract: A silo, a chemical delivery system, and a method. The silo includes a housing and a vessel positioned within the housing and configured to contain a mud chemical. The vessel includes a discharge port and a discharge valve that controls discharge of the mud chemical through the discharge port. The discharge port is configured to connect to a skid by placing the silo on the skid, and the silo has a plurality of configurations for different types of mud chemicals.

Abstract: A mixing system and method. The mixing system includes a mixer configured to mix a dry component into a fluid to generate a slurry, one or more pumps coupled with the mixer and configured to deliver the fluid thereto, and a manifold system coupled to the mixer and the one or more pumps. The manifold system includes one or more valves configured to direct the slurry from the mixer. The mixing system is operable in a first mixing mode to mix a first type of the slurry, and the mixing system is operable in a second mixing mode to mix a second type of the slurry. The manifold system is configured to prevent inert mixing of the first and second types of the slurry.

Abstract: A silo, a chemical delivery system, and a method. The silo includes a housing and a vessel positioned within the housing and configured to contain a mud chemical. The vessel includes a discharge port and a discharge valve that controls discharge of the mud chemical through the discharge port. The discharge port is configured to connect to a skid by placing the silo on the skid, and the silo has a plurality of configurations for different types of mud chemicals.

Abstract: A power system comprises a converter including an inductor core defining a gap, and a separator spanning the gap and contacting the core. The power system also includes a controller programmed to, responsive to a decrease in current ripple amplitude output by the converter to less than a first threshold, decrease power supplied by the converter. The first threshold is indicative of an inductance change through the core due to a temperature driven decrease in size of the separator.

Abstract: A vehicle includes a power converter having an inductor electrically disposed between a traction battery and an electric machine. The vehicle includes a controller configured to reduce a power limit of the power converter. The reduction is responsive to an increase of a ratio of voltage across the inductor to a rate of change of current through the inductor.

Abstract: An example method includes causing playback of a video, receiving a first input during playback of the video, and receiving a second input during playback of the video. In such methods, the second input is separate from the first input. The method also includes determining a length of time extending from the end of the first input to the beginning of the second input. The method further includes generating a digital content item including at least a video file corresponding to the video, and a sequential data list. The sequential data list includes a duration of the first input followed by a duration of the second input. The sequential data list also includes the length of time listed between the duration of the first input and the duration of the second input.

Abstract: An LED strip operable with a single input source of current providing for an extended length LED strip of continuous illumination. The LED strip includes a repeating pattern of LED circuits along a printed circuit board; each LED circuit having a constant current regulator and a plurality of LEDs in serial configuration with the constant current regulator.

Abstract: An example method includes causing playback of a video, receiving a first input during playback of the video, and receiving a second input during playback of the video. In such methods, the second input is separate from the first input. The method also includes determining a length of time extending from the end of the first input to the beginning of the second input. The method further includes generating a digital content item including at least a video file corresponding to the video, and a sequential data list. The sequential data list includes a duration of the first input followed by a duration of the second input. The sequential data list also includes the length of time listed between the duration of the first input and the duration of the second input.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: The invention relates to macrocyclic compounds capable of modulating biological processes through binding to a presenter protein and a target protein. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity. In some embodiment, the compounds of the invention “re-program” the binding of the presenter proteins to protein targets that either do not normally bind to the presenter protein.