Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

Abstract: A stepladder includes a front section having a first front leg and a second front leg. The stepladder includes a step attached to the first front leg and the second front leg. The stepladder includes a latch engaged with the step. The stepladder includes a rear section having a first rear leg and a second rear leg and a cross bar attached to the first rear leg and the second rear leg. The rear section is pivotably attached to the front section. The rear section has a first stud which extends from the first rear leg toward the second rear leg and separate and apart and not in contact with the second rear leg and not in contact with the cross bar.

Abstract: A gun-launched, non-lethal, anti-personnel projectile includes a variable thrust, solid propellant rocket motor. The rocket motor has a variable thrust profile that maintains a substantially constant kinetic energy of the projectile below a lethal threshold from a range of about 5 meters to about 400 meters.

Abstract: A stepladder includes a front section having a first front leg and a second front leg and a step attached to the first front leg and the second front leg and a latch engaged with the step. The stepladder includes a rear section having a first rear leg and a second rear leg and a cross bar attached to the first rear leg and the second rear leg. The rear section has a first stud which extends from the first rear leg toward the second rear leg and separate and apart and not in contact with the second rear leg and not in contact with the cross bar. The latch is engaged with and latched to the first stud to define an engaged position where the first front leg and the first rear leg are in an open position and form an inverted v shape and are prevented from folding together.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: Disclosed herein are embodiments of a device and method for near-infrared imaging of a patients sinus cavities. The imaging can be used for diagnosis and monitoring of different conditions such as maxillary sinusitis. The system and method can use LEDs to provide near-infrared light through the tissue of a patient, where the light can be picked up by a camera. An iso-intensity contour line map can then be created for quantitative analysis.

Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

Abstract: A stepladder includes a front section having a first front leg and a second front leg. The stepladder includes a step attached to the first front leg and the second front leg. The stepladder includes a latch engaged with the step. The stepladder includes a rear section having a first rear leg and a second rear leg and a cross bar attached to the first rear leg and the second rear leg. The rear section is pivotably attached to the front section. The rear section has a first stud which extends from the first rear leg toward the second rear leg and separate and apart and not in contact with the second rear leg and not in contact with the cross bar.

Abstract: Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of sternal retractor blades having a certain geometry and inserts placed inside the sternal retractor blades during retraction of the sternotomy incision. The blades and inserts act to tamponade the blood flow from the cut sternal edge and reduce fracturing of the sternum during retraction.

Abstract: Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating inflammatory conditions, such as rheumatoid arthritis.

Abstract: A kinetic energy training cartridge simulates the performance, weight, length, and external geometry of a tactical cartridge. The training cartridge includes a cartridge case and a projectile that is secured to cartridge case by means of a sabot. The sabot includes a rearward extension that encapsulates part of the projectile, to add weight and to increase a length to diameter ratio of the projectile, so as to decrease an intrusion volume of the projectile within the cartridge case. In a preferred embodiment, the length to diameter ratio of the projectile is at least 15.