Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: Lighting systems, apparatus, and methods are disclosed, which employ optical transmission of two-dimensional control signals to manipulate lighting elements. The lighting apparatus can include a projector with an IR LED array to wirelessly transmit pixel information onto a target space. The pixel information controls lighting elements within the target space. The two-dimensional control signals can includes subareas corresponding to lighting elements in a control array. The lighting elements can be lights producing light of desired wavelengths including infrared and/or visible wavelengths. LEDs can be used as light sources in exemplary embodiments.

Abstract: Integrated circuits may have arrays of memory elements. Data may be loaded into the memory elements and read from the memory elements using data lines. Address lines may be used to apply address signals to write address transistors and read circuitry. A memory element may include a bistable storage element. Read circuitry may be coupled between the bistable storage element and a data line. The read circuitry may include a data storage node. A capacitor may be coupled between the data storage node and ground and may be used in storing preloaded data from the bistable storage element. The read circuitry may include a transistor that is coupled between the bistable storage element and the data storage node and a transistor that is coupled between the data storage node and the data line.

Abstract: Fixed Frequency, Fixed Duration power controls methods and systems are described for application of power to electrical loads. FFFD techniques according to the present disclosure utilize power train pulses with fixed-frequency fixed-duration pulses to control power applied to a load. The load can be any type of DC load. FFFD techniques allows for controlled variation of the fixed length of the ON pulse, the Fixed length of the OFF or recovery period, the total time period for one cycle, and/or the number of pulses in that time period. Applications to electric motors, electric lighting, and electric heating are described. Related circuits are also described.

Abstract: Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis and associated conditions, methods of treating systemic lupus erythematosus and associated conditions, and methods of treating multiple sclerosis.

Abstract: A method of collaboratively editing a document includes converting an originating document to a web document comprising segmented files in a markup language; storing the web document on a server; retrieving the web document to generate edits thereto from a first participant; transmitting the first participant edits to the server and associating the first edits with the web document; retrieving the web document including first participant edits to generate additional edits thereto from a second participant; transmitting the second participant edits to the server and associating the second participant edits with the web document and the first participant edits; reviewing edits from all participants by a document administrator, accepting or rejecting edits, including conflicting edits, until desired changes are made to the web document; and converting the web document including first and second participant edits into an edited document into a proprietary format.

Abstract: Methods of treatment using IL-27 antagonists are provided. Such methods include, but are not limited to, methods of treating steroid-resistant conditions, such as asthma, chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), and inflammatory bowel disease. Such antagonists include, but are not limited to, antibodies that bind IL-27 and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to its receptor); antibodies that bind the IL-27 receptor, alpha subunit, and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to the receptor); and soluble forms of IL-27RA.

Abstract: Systems and methodologies are described that provide low-complexity soft-output detection for MIMO communication systems. Looping can be performed over a set of constellation points per spatial stream to obtain distance metrics for each of a series of transmitted streams, for which values for the other transmitted streams can be estimated using a MIMO channel matrix and a sub-optimal MIMO algorithm. Examples of MIMO algorithms that can be utilized include Per-Stream List Detection (PSLD), Lattice-Reduced Detection (LRD), and a Guided-M Algorithm. Performance can be further improved by pre-processing the MIMO channel matrix and/or by utilizing techniques for Enhanced Metric Usage (EMU).

Abstract: A MIMO receiver is provided with a preprocessor for performing QR decomposition of a channel matrix H wherein the factored reduced matrix R is used in place of H and Q*y is used in place of the received vector y in a maximum likelihood detector (“MLD”). The maximum likelihood detector might be a hard-decision MLD or a soft-decision MLD. A savings of computational complexity can be used to provide comparable results more quickly, using less circuitry, and/or requiring less consumed energy, or performance can be improved for a fixed amount of time, circuitry and/or energy. Where the MLD uses approximations, such as finite resolution calculations (fixed point or the like) or L1 Norm approximations, the reduced number of operations resulting from using the reduced matrix results in improved approximations as a result of the finite resolution operations. Other methods of reducing the channel matrix might be used for suitable and/or cumulative advantages.

Abstract: A method and circuit to control the intensity of lights, illumination fixtures, and displays using pulses of a fixed duration and a fixed frequency (FD/FF) is provided. In particular, the method may be used to control one more light sources. By varying the number of pulses in a control burst, the total current flowing through the light source may be precisely controlled providing greater accuracy than other methods, such as, for example, PWM or variable pulse frequency. The FD/FF technique may be used in conjunction with any number of light sources, and finds particular application in LED displays and for any type of LED illumination fixture.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: A double-bladed cutting device providing a practical method for obtaining costal cartilage specimens in both an operating room and research setting. The device reduces the skill and time required to fashion cartilage slices, while increasing the uniformity of the cut specimens. Furthermore, via an adjustable guide, slices can be obtained precisely from the central core of the rib. Although specimen lengths up to 4 cm are preferred, longer lengths can be attained without modification of the device. The cartilage specimen may be held in place within the device via means of compression or tension.

Abstract: Methods of treatment using IL-27 antagonists are provided. Such methods include, but are not limited to, methods of treating steroid-resistant conditions, such as asthma, chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), and inflammatory bowel disease. Such antagonists include, but are not limited to, antibodies that bind IL-27 and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to its receptor); antibodies that bind the IL-27 receptor, alpha subunit, and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to the receptor); and soluble forms of IL-27RA.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state.

Abstract: Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.