Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: A MIMO receiver is provided with a preprocessor for performing QR decomposition of a channel matrix H wherein the factored reduced matrix R is used in place of H and Q*y is used in place of the received vector y in a maximum likelihood detector (“MLD”). The maximum likelihood detector might be a hard-decision MLD or a soft-decision MLD. A savings of computational complexity can be used to provide comparable results more quickly, using less circuitry, and/or requiring less consumed energy, or performance can be improved for a fixed amount of time, circuitry and/or energy. Where the MLD uses approximations, such as finite resolution calculations (fixed point or the like) or L1 Norm approximations, the reduced number of operations resulting from using the reduced matrix results in improved approximations as a result of the finite resolution operations. Other methods of reducing the channel matrix might be used for suitable and/or cumulative advantages.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: A protection domain for a set of errors is defined using an association between data and first integrity metadata to protect data traversing an input/output datapath. The datapath has a storage device as one endpoint and a first generation integrity point for a host as an opposite endpoint. A first sub-domain is defined within the protection domain using an association between the data and second integrity metadata to further protect a portion of the datapath having a second generation integrity point as one endpoint. In another aspect, a second sub-domain is defined within the protection domain using an association between the data and third integrity metadata further protect data traversing a portion of the datapath having a third generation integrity point as one endpoint. The first and second sub-domains are nested within the protection boundary and may be in a hierarchical relationship.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: A method for dirty region logging of a file that includes receiving a request to open the file, determining each of a plurality of component files associated with the file, opening each of the plurality of component files, writing to a region of the at least one of the plurality component files, and updating a dirty region log (DRL) associated with the one of the plurality of component files to reflect the write to the region.

Abstract: A method and apparatus for non-contact determination of liquid concentrations such as the content of water, oil, dye, paint, fuel, glue, etc., in a moving or stationary mass of production such as wood, paper, powders, fabrics, sand, bricks, concrete, plants, and the like, or in other liquids such as oil spills in water, is provided. The method comprises measuring the passive emissivity of a substance, using an imaging radiometer. It has been found that an emissivity image may be used to quantify the liquid content in a substance. The invented method allows for non-contact, rapid and continuous in-line measurements.

Abstract: A system and method for generating a probability distribution indicating the probability of a range of performance ratios between computer systems. Benchmark and/or other testing results are obtained for both computer systems. For each test, a ratio of one system's performance to the other is calculated. The ratios and/or testing results may be weighted. From the performance ratios, a histogram is produced to indicate the probabilities of achieving the various ratios. Based on the distribution of probabilities, a particular performance ratio can be predicted with a corresponding level of confidence, and used for capacity planning or configuring a computing environment.

Abstract: Two Cards Combo 21 is a card game in convention with the playing method of Blackjack (twenty-one) that multiple players engage in taking turns to play their own hand against to dealer's hand. A method of playing Two Cards Combo 21 card game comprises a dealer and at least one player. It uses a shoe with six decks or eight decks of standard playing card without jokers, queens and kings (44 cards of each deck). In conjunction with standard rules of Blackjack, there are one mandatory bet which is Ante (Two cards Combo 21) and five side bets, such as, Dealer Bust, Any Pair of 2, 3, 4, 5, 6, 7, 8, 9, 10, jack, and ace, Blackjack or Combo 21, Any Even number, and Any Odd number.

Abstract: A skip-free retiming system and method for transmission of digital information in a plesiochronous data communication system is described. The system is capable of supporting an unlimited number of retimers in serial data path between a first and a last node. The retimers are configured to retime, amplify and retransmit a received data stream without altering the received data rate. Thus, the data rate from the first node is received at the same frequency at the last node, regardless of the number of retimers. In general, the retimer performs rate compensation on a retimer local clock, rather than on the data stream, so the attributes of the clean retimer clock can be applied to the data stream without changing the data rate.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The present disclosure provides 2,4-pyrimidinediamine compounds that selectively inhibit JAK kinase as compared to Syk kinase and various methods of using the JAK-selective compounds.

Abstract: Diagnosis of corruption in interrelated data entities uses a graph of nodes and edges. Datum nodes represent the data entities, relationship nodes represent the relationships among the data entities. The datum nodes are connected through their relationship nodes by the edges. When corruption is detected, the relationships are analyzed and each edge connecting a datum node to a relationship node is removed from the graph when the corresponding relationship is invalid. The datum nodes that remain connected to their relationship nodes form a subgraph and the corresponding data entities are considered correct. In one aspect, if more than one subgraph is formed, the datum nodes in the largest are used. In another aspect, the data entities and relationships are analyzed to create the graph when the data entities are assumed correct. The data entities may be data and metadata of various types that can be associated with the data.

Abstract: The invention is a system for installing a new operating system on a logical partition that has no existing software or data. The system comprises a baseline code and a process for customizing and configuring the baseline code for use in an on-demand environment. The process for customizing and configuring the baseline code comprises establishing a plurality of datasets that allow users to access the operating system after installation. The critical datasets that produce an operable system include virtual telecommunications parameters, job entry system parameters, operating system parameters, and security parameters.

Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

Abstract: A method for detecting errors in streaming media devices is described. In one embodiment, when a command to write a block of data to a streaming media device is received, integrity metadata associated with the data block is attached to the data block and written to the streaming media device together with the data block. Subsequently, when a read command pertaining to this data block is received, new integrity metadata is determined and compared to the attached metadata. If the new integrity metadata does not match the attached metadata, an error message is generated.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.

Abstract: A method of modulating immune response in an animal is disclosed. Such a method comprises: interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo.