Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: Compositions and methods are provided for use in binding opioids, such as 6-MAM, morphine, heroin, hydrocodone, oxycodone, meperidine, and fentanyl, while avoiding binding to OUD treatment agents, such as naloxone and naltrexone. Methods are also provided for use in a systematic structure-based virtual screening and design approach for identification of such antibodies. Methods are also provided for use in treating OUD. Methods are also provided for use in detecting an opioid in a sample.

Abstract: A compound of Formula (0): where Ar is one or more substituted or unsubstituted aromatic units, R is independently H, F, CN, a C1-C20 linear or branched aliphatic group or a C1-C20 linear or branched aliphatic acyl group, and n is an integer 3 or greater, is useful for sorting and dispersing carbon nanotubes (CNTs) and for producing printed electronic devices (e.g. CO2 sensors, TFTs) in which the CNTs are functionalized with the compound.

Abstract: A method of treating opioid use disorder involves administering a selective butyrylcholinesterase (BChE) inhibitor.

Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.

Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Abstract: The presently-disclosed subject matter describes fusion proteins comprising butyrylcholinesterase (BChE) having an improved production yield and biological half-life and nucleotides encoding the same.

Abstract: A method for generating a virtual operating object is provided for an electronic device. The method includes obtaining a target portrait picture on a configuration interface of a target application on the electronic device; obtaining a first picture region of the target portrait picture where a first part presents and a first part feature of the first part; determining a target part matching the first picture region in a pre-established feature image library, the target part being a part of a to-be-generated target virtual operating object in the target application; determining a target feature parameter matching the first part feature in a value range of a target part feature of the target part pre-recorded in the feature image library; and generating the target part in the target application according to the target feature parameter.

Abstract: The present invention relates to an interactive LED display device which comprises a control terminal, a plurality of unit information acquisition systems, a plurality of LED modules, a plurality of interactive sensors and interactive effective induction systems. The control terminal is connected to the plurality of unit information acquisition systems. Each unit information acquisition system is connected to the plurality of LED modules. Each LED module is connected to the plurality of interactive effective induction systems. Each effective induction system is connected to one or more interactive sensors. The present invention also relates to a display method of an interactive LED display device. The LED display device and the display method have a preferred adaptability to serious circumstance, an enhanced stability of interactive display and bring out strengthened interactive display effect.

Abstract: A method of treating opioid use disorder involves administering a selective butyrylcholinesterase (BChE) inhibitor.

Abstract: Glycine, threonine, and serine can enhance the sensitivity of bacteria to serum, plasma, or whole blood, and therefore can be used as molecules to improve the bactericidal effect of the serum, the plasma, or the whole blood.

Abstract: The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual.

Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.

Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Abstract: A gas extraction method in which high energy gas fracturing technology is used to form a fracture network in a thermal injection borehole. Then high-pressure, cyclically temperature-changing steam is injected into the borehole using a spinning oscillating-pulse jet nozzle to form oscillating superheated steam, alternatingly impacting and heating the coal body. The high energy gas forms a fracture network that provides channels for passage of the superheated steam, while oscillating changes in steam temperature and pressure also promote crack propagation and perforation of the coal body; the combined effect of alternation of the two enhances gas desorption and extraction efficiency.

Abstract: A method for combining integrated drilling, flushing and slotting with thermal injection to enhance coalbed gas extraction, applicable to managing gas extraction from microporous, low-permeability, high-adsorption coalbed areas. A gas extraction borehole is drilled within a certain distance of a predetermined drilling, flushing and slotting borehole, and, once sealed, is used for gas extraction. An integrated drilling, flushing and slotting drill bit is used to sink the borehole, which is then sealed. Concentration variation in the gas extraction borehole is monitored in real time, and when concentration is below 30%, borehole is opened and high-temperature steam is injected by means of a steam generator, after which the borehole is again closed.

Abstract: The present invention relates to an interactive LED display device which comprises a control terminal, a plurality of unit information acquisition systems, a plurality of LED modules, a plurality of interactive sensors and interactive effective induction systems. The control terminal is connected to the plurality of unit information acquisition systems. Each unit information acquisition system is connected to the plurality of LED modules. Each LED module is connected to the plurality of interactive effective induction systems. Each effective induction system is connected to one or more interactive sensors. The present invention also relates to a display method of an interactive LED display device. The LED display device and the display method have a preferred adaptability to serious circumstance, an enhanced stability of interactive display and bring out strengthened interactive display effect.

Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Abstract: A method for combining integrated drilling and slotting with oscillating thermal injection to enhance coalbed gas extraction, applicable to managing gas extraction from microporous, low-permeability, high-adsorption coal seam areas. A number of slots are formed within a thermal injection/extraction borehole by means of integrated drilling and slotting technology; a steam generator, is then used to three high-pressure, cyclically temperature-changing steam into said borehole; the steam passing through a spinning, oscillating-pulse jet nozzle forms an oscillating superheated steam, heating the coal body. The present method overcomes the limitations of simple permeability-increasing techniques, the slotting by means of hydraulic.