Abstract: A substrate plasma-processing apparatus for plasma-processing a surface of an electrode of an organic light emitting device. The substrate plasma-processing apparatus may adjust the distance between a first electrode and a substrate and adjust the distance between a second electrode and the substrate.

Abstract: Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (?)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (?)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.

Abstract: A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/Y332G, and A199S/F227A/S287G/A328W/E441D all have enhanced catalytic efficiency for (?)-cocaine compared with wild-type BChE.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.

Abstract: A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/Y332G, and A199S/F227A/S287G/A328W/E441D all have enhanced catalytic efficiency for (?)-cocaine compared with wild-type BChE.

Abstract: This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by binding to the substrate binding domain.

Abstract: The present invention relates to a mobile phone and a method for its operation and control. The mobile phone is capable of receiving the message sent by other mobile phones through a message transmission system. The method comprises: receiving the message from another mobile phone, wherein the received message comprises a presentation part and an associated control part, the control part being used for the control and management of the processing of the received message; extracting the control part from the received message; and executing the operation related to the message based on the extracted control part. According to an embodiment, if the control part received by the mobile phone comprises the notification mode control command, the mobile phone issues a message notification according to the notification mode control command, disregarding the message notification mode pre-configured on the mobile phone. Thus the requirement of the sender personalized message service can be satisfied.

Abstract: A two-way audio communication device includes a housing (190) with passageways (491, 492). Electronics (310) are located in the housing. The device has a retractable speaker or earpiece (220) and a retractable microphone (410). A spool (340) is adjacent to the housing. Electrical wires (420) electrically couple the retractable microphone to the electronics, and the electrical wires are retractable through the passageways and onto the spool.

Abstract: Disclosed here is a composition containing menthol and menthyl lactate, and its preparation method and its applications as a cooling agent and a flavoring agent. The present invention provides a composition characterized in that it comprises menthol and menthyl lactate in a ratio by weight in the range of 1:4˜4:1 and the corresponding crystallization point is below room temperature of 25° C. Such composition has the advantages of being liquid at room temperature; easy to use as a cooling agent or a flavoring agent; no need to use heat to melt menthol and menthyl lactate, which not only saves time, money and heating equipment, but also simplifies manufacturing process and can be used in cold processes at room temperature.

Abstract: Disclosed here is a composition containing menthol and menthyl lactate, and its preparation method and its applications as a cooling agent and a flavoring agent.

Abstract: This invention relates to a process for producing a composition comprising 4,4-dimethyl-6-isopropyl-1,2,3, 4-tetrahydronaphthalen-1-one. The composition of the invention is prepared by the oxidation of a 1,1-dimethyl-7-isopropyl -1,2,3,4-tetrahydronaphthalene raw material, which may be prepared by rearrangement and aromatization of longifolene. The invention also relates to perfume comprising the composition of the invention. The process uses organic acid salts of metals, including Cr, Fe, Mn, Ni, and the like, as oxidizing catalysts to produce the compound, which has a floral odor that diffuses easily and is long lasting. The fragrance of 4,4-dimethyl-6-isopropyl-1,2,3, 4-tetrahydronaphthalen-1-one is similar to various natural essential oils and their mixtures. Due to both its floral and woody odor, the 4,4-dimethyl-6-isopropyl-1,2,3, 4-tetrahydronaphthalen-1-one compound can be advantageously used as an ingredient in various types of perfumery materials.

Abstract: A pixel of a color video image is converted from one color format having luminance and chrominance signals, e.g., YUV format, to a destination format, e.g., RGB or CMY formats, by forming luminance and chrominance component words which include partitioned words representing various color components of the luminance and chrominance signals. The luminance and chrominance component words are summed using a partitioned addition operation to thereby accumulate the various color components of the luminance and chrominance signals simultaneously and in parallel. Formation of the luminance and chrominance component words is, in some instances, done by a load and store unit of a central processing unit while a graphics execution unit simultaneously sums the luminance and chrominance components using the partitioned addition operation. By using this technique, conversion of pixels of a color motion image from YUV format to a different format, e.g.

Abstract: A method and apparatus for fast and cost-effective digital video decompression is disclosed. The invention implements the inverse quantization, inverse discrete cosine transform and motion compensation functions for an MPEG decoder in a pipelined parallel processor. The IDCT and motion compensation functions are implemented to maximize parallelization by using partitioned arithmetic and logic operations in a superscalar microprocessor. This approach drastically reduces the total number of instruction cycles required to perform the IDCT and motion compensation functions.