Abstract: In an embodiment, a process to predict an outcome of a competition includes receiving time-stamped position information of participant(s), the time-stamped position information captured by a telemetry tracking system during the competition. The process includes calculating while the competition is ongoing a covariate parameter for each of one or more participants at a point in time, where each respective covariate parameter is derived from the time-stamped position information of a corresponding participant at the point in time. The process includes predicting the outcome of the competition, as of the point in time, based at least in part on (i) a difference between a calculated competitor strength of the first competitor the second competitor based on historical data associated with the competitors, and (ii) the calculated first covariate parameter(s).

Abstract: Techniques are disclosed to add augmented reality to a sub-view of a high resolution central video feed. In various embodiments, a central video feed is received from a first camera on a first recurring basis and time-stamped position information is received from a tracking system on a second recurring basis. The central video feed is calibrated against a spatial region encompassed by the central video feed. The received time-stamped position information and a determined plurality of tiles associated with at least one frame of the central video feed are used to define a first sub-view of the central video feed. The first sub-view and a homography defining placement of augmented reality elements on the at least one frame of the central video feed are provided as output to a device configured to use the first sub-view and the homography display the first sub-view.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: An impact absorbing ski binding interface device includes an elongated top plate having a toe end and a heel end adapted to engage a boot toe and a boot heel, respectively, and a bottom plate adapted to engage a ski, thereby securing the device between the boot and ski. A plurality of constant force spring linkages between the top plate and the bottom plate include a constant force spring linkage between the toe end and the bottom plate, and a constant force spring linkage between the heel end and the bottom plate, such that each of the constant force spring linkages have an opposed pair of deformable members for exerting a counterforce to vertical displacement forces between the top plate and the bottom plate for load mitigation.

Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a recombinase complex, a cas effector complex comprising a cas effector and at least one engineered guide polynucleotide configured to hybridize to the target nucleic acid site, and the recombinase complex wherein said recombinase complex is configured to recruit the cargo nucleotide to the target nucleic acid site.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents for administration by inhalation preferably targeting genes expressed in the respiratory system, as well as methods of inhibiting expression of a target gene after administration by inhalation, preferably a gene expressed in the respiratory system.

Abstract: A process to partition a video feed to segment live player activity includes receiving, on a first recurring basis, a transmission of a central video feed from a first camera. The central video feed is calibrated against a spatial region represented in at least two dimensions that is encompassed by the central video feed. The process includes receiving, on a second recurring basis, a respective time-stamped position information from each tracking device in a plurality of tracking devices. Each tracking device is worn by a corresponding subject on the spatial region and transmits positional information that describes a time-stamped position of the corresponding subject in the spatial region. The process uses the received information and the calibration to define a first sub-view of the central video feed associated with a first subject. The first sub-view comprises a corresponding sub-frame associated with the first subject.

Abstract: A system and method for presenting three-dimensional content that can present the three-dimensional content with a fidelity that can be matched to a fidelity or perceivable depth achievable by the display. The system or method can include receiving content, converting the content to a shared representation that can be used for any display, displaying the content on the display via the shared representation.

Abstract: Ullage float assemblies for fuel tanks are disclosed including a guide member with a retaining element mounted to a valve body which includes a first valve port and a second valve port in fluid communication. Methods of preventing spillage of fuel from a fuel tank during a refueling and a diurnal fuel volumetric expansion event are also disclosed. The assemblies and methods.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2?-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.

Abstract: The invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A fuel valve device and a method of controlling fuel flow between a fuel tank and an engine are disclosed. A fuel valve comprises an inlet conduit including an inlet end connectable to a fuel tank and a central axis, an outlet conduit including an outlet end opposite the inlet end connectable to an engine. The outlet conduit has a central axis offset from the inlet conduit central axis. A movable valve ball is configured to block fuel flow from the inlet end to the outlet end at a predetermined pressure and to permit the fuel flow from the inlet end to the outlet end when pressure in the fuel valve device exceeds the predetermined pressure, movable along a travel axis defining an angle with the inlet conduit central axis that is greater than 5 degrees and less than 90 degrees.

Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: Techniques are described for managing communications between multiple intercommunicating computing nodes, such as multiple virtual machine nodes hosted on one or more physical computing machines or systems. In some situations, users may specify groups of computing nodes and optionally associated access policies for use in the managing of the communications for those groups, such as by specifying which source nodes are allowed to transmit data to particular destinations nodes. In addition, determinations of whether initiated data transmissions from source nodes to destination nodes are authorized may be dynamically negotiated for and recorded for later use in automatically authorizing future such data transmissions without negotiation. This abstract is provided to comply with rules requiring an abstract, and it is submitted with the intention that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The disclosure provides a process for preparing solid tri(C1-C4 alkyl)ammonium dihydrogen phosphates such as triethylammonium dihydrogen phosphate, in high yield, and in a free-flowing particulate form. The solid product advantageously possesses less than about 1500 ppm of aprotic organic solvents, less than about 1500 ppm of C1-C5 alkanols, and less than about 500 ppm of water, as determined by Karl Fischer titration.