Abstract: Closed-loop systems and methods for controlling pH. The system includes a working electrode, a counter electrode, a reference electrode, a first ion-sensitive field-effect transistor (ISFET), a second ISFET, and an electronic controller. The working electrode, the counter electrode, the reference electrode, and a first sensing terminal of the first ISFET are immersible in an active solution. A second sensing terminal of the second ISFET is immersible in a reference solution. The electronic controller is configured to apply a first amount of current or voltage to the working electrode and determine a differential voltage between the first ISFET and the second ISFET. The electronic controller is also configured to set a second amount of current or voltage to reduce a difference between the differential voltage and a target voltage. The electronic controller is further configured to apply the second amount of current or voltage to the working electrode.

Abstract: Systems and methods to clamp an impeller on a shaft in a centrifugal compressor. The embodiments as disclosed herein may include clamping individual impeller independently to the shaft, which may reduce the tolerance stack-up effect of a plurality of impellers. The impeller can be clamped to the shaft by positioning, for example, a relatively stiff support (e.g. a shaft locknut) on a front side of the impeller. The impeller can also be clamped to the shaft by a relatively flexible support to compensate for e.g. thermal expansion/contraction of the impeller. The embodiments as disclosed herein are particularly suitable for a multi-stage impeller.

Abstract: A bifunctional polymer is functionalized at one end with an azlactone end group to conjugate biomolecules of interest, and is functionalized at another end with an azide anchor group to attach the polymer to a substrate. Methods of making the bifunctional polymer are also provided. A coated substrate includes the bifunctionalized polymers on the surface of a substrate. Methods of making the coated substrate are also provided. A microarray includes a plurality of discrete regions, each region including the coated substrate.

Abstract: A method for detecting an amount of an analyte in a solution includes adding an electrochemically active agent to the solution; applying an electrical current to a working electrode in contact with the solution to initiate the electrochemical redox reaction to change a pH of the solution from a first pH value to a second pH value; incubating the solution at the second pH value to allow the analyte to dissociate from the other molecules in the solution and to bind to a capture molecule connected to the working electrode via a linker; reacting a detecting probe with the analyte to allow the detecting probe to bind to the analyte, the detecting probe having a signaling tag attached thereto and configured to produce a signal at the second pH value; and collecting the signal to calculate the amount of the analyte in the solution.

Abstract: In order to facilitate the entity resolution and entity activity tracking and indexing, systems and methods include receiving first source records from a first database and second source records from a record database. A candidate set of second source records is determined by a heuristic search in the set of second source records. A candidate pair feature vector associated with each candidate pair of first and second source records is generated. An entity matching machine learning model predicts matching first source records for each candidate second source record based on the respective candidate pair feature vector. An aggregate quantity associated with the matching first source records is aggregated from a quantity associated with each first source record, and a quantity index for each candidate second source record is determined based the aggregate quantities. Each quantity index is displayed to a user.

Abstract: A point of care device, comprises a chamber configured to contain a swab. Once a swab is loaded, the device introduces a buffer into the chamber, then lyses cells collected by the swab. Probes such as padlock probes target a specified content such as a virus (e.g., SARS-CoV-2 RNA) and will bind, splint ligate, and rapidly isothermally amplify (e.g., using rolling circle amplification). Also described is a wastewater pathogen tracking dashboard and schema for detecting and tracking pathogen spread within communities by monitoring microbial and viral RNA.

Abstract: Optimization systems and methods for optimizing business operations and asset systems are disclosed. A system includes digital twins corresponding to asset systems; business models corresponding to business operations; and an electronic control unit (ECU). The ECU is programmed to: implement an asset optimizer module, where implementing the asset optimizer module interconnects the digital twins for optimization; execute the asset optimizer module, where the asset optimizer module optimizes the digital twins to obtain one or more optimization parameters for the asset systems; implement a system optimizer module, where the system optimizer module receives the one or more optimization parameters and the business models; execute the system optimizer module, where the system optimizer module generates operation protocols for the business models; and output, to a user, the operation protocols for implementation in a real-world asset system.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a capacity control valve that has a curved surface facing a flow of refrigerant from the first stage to the second stage. The capacity control valve can allow or obstruct flow through the side stream injection port. The capacity control valve can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. The side stream injection port and the capacity control valve can be ring-shaped. The side stream injection port and the capacity control valve can allow at least some of the side stream to be introduced on a side of the capacity control valve opposite the curved surface.

Abstract: A device to electrochemically sequence DNA that includes a redox species includes at least one edge electrode, at least one stack of insulator material, and a pair of DNA translocation electrodes including a DNA translocation working electrode and a DNA translocation counter electrode, where the thickness of the at least one edge electrode is about 0.5 nanometers, and the thickness of the at least one stack of insulator material is about 10 nanometers. Methods of electrochemically sequencing a strand of DNA are also provided.

Abstract: Images related to one or more attacks to a service provider system may be analyzed to improve the security of the service provider system. Each of the images may be segmented into multiple segments. Each of the segments is analyzed independently to determine whether the segment includes obfuscated data and if so, which one of the data obfuscation techniques was used to generate the obfuscated data. Additional information regarding the obfuscated data may be derived from other segments that include unobfuscated data and from the metadata of the image. A data restoration algorithm may be configured accordingly to restore the obfuscated data. The restored data, as well as a context derived for the image, may be used to adjust one or more security parameters of the service provider system to improve the security of the service provider system.

Abstract: Systems, methods, and computer program products that enable system-wide probabilistic forecasting, alerting, optimizing and activating resources in the delivery of care to address both immediate (near real-time) conditions as well as probabilistic forecasted operational states of the system over an interval that is selectable from the current time to minutes, hours and coming days or weeks ahead are provided. There are multiple probabilistic future states that are implemented in these different time intervals and these may be implemented concurrently for an instant in time control, near term, and long term. Those forecasts along with their optimized control of hospital capacity may be independently calculated and optimized, such as for a dynamic workflow direction over the next hour and also a patient's stay over a period of days.

Abstract: An apparatus includes an auxiliary light includes a housing defining a front opening, a light emitting in the housing, and a transparent cover is mounted over the front opening. A plurality of fins are mounted to the housing and extend rearwardly from the front opening. The housing defines a cavity of non-rectangular shape from the opening to a backwall of the cavity. A circuit board has a perimeter conforming to the non-rectangular shape. The circuit board may include cutouts for a plug through the backwall. A heat conducting pad, such as graphite is interposed between the circuit board and the backwall and may likewise conform to the non-rectangular shape.

Abstract: An apparatus includes an auxiliary light includes a housing defining a front opening, a light emitting in the housing, and a transparent cover is mounted over the front opening. A plurality of fins are mounted to the housing and extend rearwardly from the front opening. The housing defines a cavity of non-rectangular shape from the opening to a backwall of the cavity. A circuit board has a perimeter conforming to the non-rectangular shape. The circuit board may include cutouts for a plug through the backwall. A heat conducting pad, such as graphite is interposed between the circuit board and the backwall and may likewise conform to the non-rectangular shape.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for generating compact tree representations applicable to machine learning. In one embodiment, a system is introduced that can retrieve a decision tree structure to generate a compact tree representation model. The compact tree representation model may come in the form of a matrix design to maintain the relationships expressed by the decision tree structure.

Abstract: A sensor and a corresponding method measure the pH of a solution without using an external reference electrode. The pH sensor has at least one functionalized electrode with an attached first redox active molecule and an attached second redox active molecule that are differently sensitive to pH and oxidize/reduce at different voltages, and a difference in peaks of a response of the two molecules to applied electrical parameter is measured and correlated to a particular pH.

Abstract: Shared risk representation in networks for troubleshooting, assignment, and propagation across layers includes obtaining a configuration for a format to represent shared risks in a network; assigning a value to a plurality of shared risks in the network utilizing the format and utilizing a plurality of assignment techniques including automatic assignment and manual assignment; propagating the assigned values of the plurality of shared risks across one or more layers in the network; and storing the assigned values for use in path computation in the network.

Abstract: In order to facilitate the entity resolution and entity activity tracking and indexing, systems and methods include receiving first source records from a first database and second source records from a record database. A candidate set of second source records is determined by a heuristic search in the set of second source records. A candidate pair feature vector associated with each candidate pair of first and second source records is generated. An entity matching machine learning model predicts matching first source records for each candidate second source record based on the respective candidate pair feature vector. An aggregate quantity associated with the matching first source records is aggregated from a quantity associated with each first source record, and a quantity index for each candidate second source record is determined based the aggregate quantities. Each quantity index is displayed to a user.

Abstract: A server system for electronic games includes a memory and a processor configured to execute instructions stored in the memory. When the instructions are executed, the instructions cause the processor to receive from a communication device, a plurality of first signals generated in response to the communication device entering one or more predefined zones associated with the electronic games, and generate, based on the plurality of first signals, a heat map that defines one or more cells based upon a magnitude of a data element of the first signals.

Abstract: Methods, systems, and devices for operating a ferroelectric memory cell or cells are described. A ground reference scheme may be employed in a digit line voltage sensing operation. A positive voltage may be applied to a memory cell; and after a voltage of the digit line of the cell has reached a threshold, a negative voltage may be applied to cause the digit line voltages to center around ground before a read operation. In another example, a first voltage may be applied to a memory cell and then a second voltage that is equal to an inverse of the first voltage may be applied to a reference capacitor that is in electronic communication with a digit line of the memory cell to cause the digit line voltages to center around ground before a read operation.