Abstract: Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.

Abstract: Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.

Abstract: A thermoacoustic transducer integrating at least one piezoelectric element having a first surface and a second surface, a potential electrode that is electrically connected to the second surface, a ground electrode that is electrically connected to the first surface, a switch electrically connected to both the potential electrode and the ground electrode, a timer configured to match a pulse emanating from a radio-frequency emitter, further wherein the potential electrode and the ground electrode are electrically connected through an impedance when the switch is in an active state, further wherein the potential electrode and the ground electrode are not electrically connected when the switch is in an inactive state; and a housing accommodating the at least one piezoelectric element, potential electrode, ground electrode, and switch.

Abstract: The present disclosure relates to antibodies specific to Zika virus and methods for detecting Zika virus infection in a subject. The present disclosure also relates to therapeutic antibodies useful in reducing viral load.

Abstract: A thermoacoustic transducer integrating at least one piezoelectric element having a first surface and a second surface, a potential electrode that is electrically connected to the second surface, a ground electrode that is electrically connected to the first surface, a switch electrically connected to both the potential electrode and the ground electrode, a timer configured to match a pulse emanating from a radio-frequency emitter, further wherein the potential electrode and the ground electrode are electrically connected through an impedance when the switch is in an active state, further wherein the potential electrode and the ground electrode are not electrically connected when the switch is in an inactive state; and a housing accommodating the at least one piezoelectric element, potential electrode, ground electrode, and switch.

Abstract: A method for controlling buckling in subsea pipelines involves identifying spaced-apart sections of a subsea pipeline suitable for controlled lateral buckling. Sets of buoyancy modules are installed at each spaced-apart section and are selected to support the spaced-apart sections of the subsea pipeline in a neutrally buoyant condition at the seafloor when the subsea pipeline is in service. Any buckling caused by thermal expansion of the subsea pipeline is distributed to two or more of the spaced-apart sections, causing the two or more spaced-apart sections to deflect laterally along the seafloor outwardly from an initial as-laid position.

Abstract: A method and system for optimizing RF energy delivery to a tissue ROI with a thermoacoustic system includes directing with a RF applicator, RF energy pulses into the tissue ROI having an object of interest and a reference separated by a boundary; detecting with a thermoacoustic transducer, a multi-polar thermoacoustic signal generated at the boundary in response to the RF energy pulses and processing the multi-polar acoustic signal to determine a peak-to-peak amplitude; detecting with the thermoacoustic transducer, an artifact multi-polar thermoacoustic signal generated at a location other than the boundary and processing it to determine a peak-to-peak amplitude; utilizing an electromagnetic model coupled with a model of patient anatomy to place dielectric or conducting materials near the thermoacoustic transducer or the RF applicator to optimize a signal-to-noise ratio of the multi-polar thermoacoustic signal generated at the boundary or minimize the artifact multi-polar thermoacoustic signal generated at a

Abstract: A graphical user interface provides network security administrators a tool to quickly and easily create one or more courses of action for automatic response to a network threat. The courses of action are hardware and system agnostic, which allows a common response task to be implemented by an underlying response engine for any or multiple similar-function devices regardless of brand or version. The course of action builder allows the administrator to use a simple, graphic-based, business modeling concept to craft and design security response processes rather than having to hard code response routines specific to each piece of hardware on the network. The graphic interface model allows the user of the threat response software incorporating the course of action builder to easily understand the overall flow and paths the response may take, as well as understand the data requirements and dependencies that will be evaluated.

Abstract: A method and system for estimating fractional fat content of an object of interest. The method and system include a thermoacoustic imaging system comprising an adjustable radio frequency (RF) applicator configured to emit RF energy pulses into the region of interest and heat tissue therein and an acoustic receiver configured to receive bipolar acoustic signals generated in response to heating of tissue in the region of interest; and one or more processors. The one or more processors are able to process bipolar acoustic signals received by the acoustic receiver in response to RF energy pulses emitted into the region of interest using the RF applicator to determine a setting for the RF applicator that yields bipolar acoustic signals with at least one enhanced metric thereof, determine an impedance of the RF applicator used to yield acoustic bipolar signals with the enhanced at least one metric, and estimate fractional fat content of the object of interest using the determined impedance.

Abstract: A method and enhancements for the decontamination of water containing one or more PFAS contaminants includes introducing a foaming agent into the water, and injecting a gas through a diffuser and into the water so as to form a plurality of bubbles in the water, the one or more PFAS contaminants accumulating on the plurality of bubbles. The plurality of bubbles is allowed to rise, forming a foam at the surface of the water. The resulting foam is then collected and transported away from the surface of the water, where it condenses into a liquid and is treated to regulatory standards.

Abstract: A graphical user interface provides network security administrators a tool to quickly and easily create one or more courses of action for automatic response to a network threat. The courses of action are hardware and system agnostic, which allows a common response task to be implemented by an underlying response engine for any or multiple similar-function devices regardless of brand or version. The course of action builder allows the administrator to use a simple, graphic-based, business modeling concept to craft and design security response processes rather than having to hard code response routines specific to each piece of hardware on the network. The graphic interface model allows the user of the threat response software incorporating the course of action builder to easily understand the overall flow and paths the response may take, as well as understand the data requirements and dependencies that will be evaluated.

Abstract: A disposable absorbent article of a brief or pull-up type incorporates a breathable laminate material composed of two layers. The laminate is an elastic material and may include non-elastic portions created by deactivating the material. The laminate material may be made breathable by the ultrasonic bonding process used to create the laminate. A third layer is adhered or bonded to the laminate and with leg elastics positioned between the laminate that the third layer. The absorbent article includes an absorbent assembly that overlaps with the non-elastic portions of the laminate.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods of treating arthritogenic alphavirus infection and methods of screening.

Abstract: An apparatus for providing improved security to an outward-swing door of a vehicle. The outward-swing door is on a sidewall of a main housing of the vehicle and has a pivotal end and a distal end opposite to the pivotal end. The outward-swing door is outwardly pivotable about the pivotal end thereof. The apparatus comprises a connecting structure for coupling to a bottom wall of the main housing, a base structure for coupling to the connecting structure so as to locate adjacent the outward-swing door and outside a swing path of the outward-swing door, and a blocking structure demountably coupled to the base structure, at least a portion thereof extendable into the swing path of the outward-swing door for restricting the outward-swing door to open to a predefined maximum extent.

Abstract: A method for providing an image of a subject by utilizing an array of transmission elements in a thermoacoustic imaging apparatus.

Abstract: A graphical user interface provides network security administrators a tool to quickly and easily create one or more courses of action for automatic response to a network threat. The courses of action are hardware and system agnostic, which allows a common response task to be implemented by an underlying response engine for any or multiple similar-function devices regardless of brand or version. The course of action builder allows the administrator to use a simple, graphic-based, business modeling concept to craft and design security response processes rather than having to hard code response routines specific to each piece of hardware on the network. The graphic interface model allows the user of the threat response software incorporating the course of action builder to easily understand the overall flow and paths the response may take, as well as understand the data requirements and dependencies that will be evaluated.

Abstract: A graphical user interface provides network security administrators a tool to quickly and easily create one or more courses of action for automatic response to a network threat. The courses of action are hardware and system agnostic, which allows a common response task to be implemented by an underlying response engine for any or multiple similar-function devices regardless of brand or version. The course of action builder allows the administrator to use a simple, graphic-based, business modeling concept to craft and design security response processes rather than having to hard code response routines specific to each piece of hardware on the network. The graphic interface model allows the user of the threat response software incorporating the course of action builder to easily understand the overall flow and paths the response may take, as well as understand the data requirements and dependencies that will be evaluated.

Abstract: A method for manufacturing a radio frequency (RF) applicator which includes covering a ceramic insert with a coating, wherein the ceramic insert has dimensions that substantially match an internal volume of an open-ended, hollow waveguide, and wherein the ceramic insert has a recess therein configured to accept a radio frequency emitter, heating the waveguide to a temperature that is above a melting point of the coating, placing the coated ceramic insert into the internal volume of the heated waveguide, wherein the internal volume is completely filled except for the recess, and cooling the waveguide, ceramic insert, and coating to a temperature below the melting point of the coating so that the coating solidifies and fills gaps between facing surfaces of the insert and the waveguide.