Abstract: An absorbent article includes front and rear portions and a fastener for connecting side edges of the front and rear portions. The fastener includes a grasping element attached to an outer surface of the fastener to provide for grasping by the wearer or caregiver. The grasping element may be formed of flexible material and may have a variety of configurations, including a tube, a flange, a tunnel or a pocket.

Abstract: A radio frequency applicator comprises an open-ended, hollow waveguide having an aperture therein. A solid insert is positioned within the waveguide. The solid insert has a recess formed therein that is aligned with the aperture. Filler material is provided between facing surfaces of the waveguide and the insert to fill gaps therebetween. A radio frequency (RF) source extends through the aperture and into the recess and is configured to generate RF energy pulses.

Abstract: A disposable, wearable article can be used for collecting a sample and performing urinalysis. The article incorporates a test port feature to simplify this function. The test port has a resealable cover that can be used to selectively expose an aperture through the backsheet of the disposable article. The test port is used to position test devices, such as urine test strips to urine collected in the disposable article.

Abstract: A method and system for estimating fractional fat content of an object of interest. The method and system include a thermoacoustic imaging system comprising an adjustable radio frequency (RF) applicator configured to emit RF energy pulses into the region of interest and heat tissue therein and an acoustic receiver configured to receive bipolar acoustic signals generated in response to heating of tissue in the region of interest; and one or more processors. The one or more processors are able to process bipolar acoustic signals received by the acoustic receiver in response to RF energy pulses emitted into the region of interest using the RF applicator to determine a setting for the RF applicator that yields bipolar acoustic signals with at least one enhanced metric thereof, determine an impedance of the RF applicator used to yield acoustic bipolar signals with the enhanced at least one metric, and estimate fractional fat content of the object of interest using the determined impedance.

Abstract: Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.

Abstract: A radio frequency applicator comprises an open-ended, hollow waveguide having an aperture therein. A solid insert is positioned within the waveguide. The solid insert has a recess formed therein that is aligned with the aperture. Filler material is provided between facing surfaces of the waveguide and the insert to fill gaps therebetween. A radio frequency (RF) source extends through the aperture and into the recess and is configured to generate RF energy pulses.

Abstract: A power generation system having a combustion engine with a Rankine bottoming cycle, the system including a first flow path for a process fluid and a second flow path for a working fluid, and a heat exchanger arranged along both the first and the second flow paths to transfer waste heat from the process fluid to the working fluid. The heat exchanger includes a first flow conduit being bounded by a first wall section and configured to convey the process fluid, a second flow conduit to convey the working fluid, the second flow conduit being bounded by a second wall section spaced apart from the first wall section to define a gap therebetween, and a thermally conductive structure arranged within the gap and joined to the first and second wall sections to transfer heat therebetween, the gap being fluidly isolated from both the process fluid and the working fluid.

Abstract: A method and system for enhancing radio frequency energy delivery to a tissue region of interest. The method and system direct with a radio frequency (RF) applicator, one or more RF energy pulses into the tissue region of interest, the tissue region of interest comprising an object of interest and at least one reference that are separated by at least one boundary; detect with an acoustic receiver, at least one bipolar acoustic signal generated in the tissue region of interest in response to the RF energy pulses and processing the at least one bipolar acoustic signal to determine a peak-to-peak amplitude thereof; adjust the RF applicator to maximize the peak-to-peak amplitude of bipolar acoustic signals generated in the tissue region of interest in response to RF energy pulses generated by the adjusted RF applicator; and direct with the adjusted RF applicator, one or more RF energy pulses into the region of interest.

Abstract: A disposable, wearable article can be used for collecting a sample and performing urinalysis. The article incorporates a test port feature to simplify this function. The test port has a resealable cover that can be used to selectively expose an aperture through the backsheet of the disposable article. The test port is used to position test devices, such as urine test strips to urine collected in the disposable article.

Abstract: Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.

Abstract: A graphical user interface provides network security administrators a tool to quickly and easily create one or more courses of action for automatic response to a network threat. The courses of action are hardware and system agnostic, which allows a common response task to be implemented by an underlying response engine for any or multiple similar-function devices regardless of brand or version. The course of action builder allows the administrator to use a simple, graphic-based, business modeling concept to craft and design security response processes rather than having to hard code response routines specific to each piece of hardware on the network. The graphic interface model allows the user of the threat response software incorporating the course of action builder to easily understand the overall flow and paths the response may take, as well as understand the data requirements and dependencies that will be evaluated.

Abstract: The present disclosure provides an aqueous composition comprising a purified thermostable polypeptide with biological activity, and a purified thermolabile water-soluble substance which in a functional conformation at a permissive temperature absorbs light and/or exhibits fluorescence, wherein the maximal permissive temperature of the polypeptide is above the maximal permissive temperature of the substance. The present disclosure further provides methods employing such a composition, and kits containing ingredients to form such a composition.

Abstract: A method for the decontamination of water containing one or more PFAS contaminants includes injecting a gas through a diffuser and into the water so as to form a plurality of bubbles in the water, the one or more PFAS contaminants accumulating on the plurality of bubbles. The plurality of bubbles is allowed to rise, forming a foam at the surface of the water. The resulting foam is then collected and transported away from the surface of the water, where it condenses into a liquid and can be treated and/or disposed of.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs are disposed in the notches.

Abstract: A floating amusement apparatus includes a base, at least one elevated platform secured to and supported above the base and a plurality of user-interactive amusement accessories secured to the base or the at least one elevated platform. The base includes a modular floating dock. The floating amusement apparatus is adapted to be mobile.

Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle is provided. The central tire inflation system includes a rotary union assembly having a housing that is coupled to and rotates with the hubcap. The housing is rotationally coupled to a stationary shaft. A flexible torque transfer shaft is connected to the stationary shaft on one end and to an axle plug on the other end. The axle plug has a hub forming a bore where the hub is movable on a web of material. The flexible torque transfer shaft and hub have cooperative non-circular shapes to resist rotation. An air vent is provided in the rotary union assembly that is isolated from the lubrication area, which inhibits the pressurized air from the central tire inflation system from pressurizing the lubrication area.

Abstract: A slurry distributor for use in a continuous manufacturing process includes an inlet opening and a shaped duct adapted to receive a flow of slurry provided at the inlet opening. The shaped duct has a parabolic guide surface adapted to redirect the flow of slurry. An outlet opening in fluid communication with the shaped duct is adapted to discharge the flow of slurry from the slurry distributor.

Abstract: Devices, kits, and methods useful in the treatment of Obstructive Sleep Apnea (OSA) are described. Example devices include a jig, a first needle, a second needle, and a third needle. An example jig comprises a drill guide and a tongue depressor. A first needle comprises an elongate shaft that defines a bend and a curve. A second needle comprises an elongate shaft that defines a curve. A third needle comprises an elongate shaft that defines a curve.

Abstract: A disposable absorbent article of a brief or pull-up type incorporates a breathable laminate material composed of three layers. The laminate is an elastic material and may include non-elastic portions created by deactivating the material. The laminate material may be made breathable by the ultrasonic bonding process used to create the laminate. The absorbent article includes an absorbent assembly that overlaps with the non-elastic portions of the laminate.