Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hepatitis B virus gene are described. Pharmaceutical compositions comprising one or more HBV RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi triggers to infected liver in vivo provides for inhibition of HBV gene expression and treatment.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2? (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2? RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2? RNAi triggers to tumor cells in vivo provides for inhibition of Hif2? gene expression and treatment of cancer.

Abstract: RNA interference (RNAi) triggers for inhibiting the expression of Factor XII (F12) gene through the mechanism of RNA interference are described. Pharmaceutical compositions comprising one or more F12 RNAi triggers together with one or more excipients capable of delivering the RNAi trigger(s) to a liver cell in vivo are also described. Delivery of the F12 RNAi trigger(s) to liver cells in vivo provides for inhibition of F12 gene expression and treatment of angioedema, including hereditary angioedema (HAE) and venous thromboembolism (VTE), and diseases associated with angioedema.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases.

Abstract: The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.

Abstract: A permanent frost protected shallow foundation footing for a building is assembled from a plurality of form parts arranged in a chain that is partially below ground level to form a foundation perimeter. The form parts are made of a lightweight material such as insulating foam material shaped as an elongated sectional unit with an overhang part overhanging a cavity part of an interior cavity. The interior cavity has an opening for receiving a concrete pour concurrent with a concrete pour of a floor. Open ends of the assembled sectional units abut each other in end-to-end alignment to form an elongated cavity inside the perimeter chain of form parts that is filled with concrete. The overhang part may have a foot shape that fits inside the interior cavity of another form part that may also have a foot shape for compact storage or transport prior to assembly.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: A permanent frost protected shallow foundation footing for a building is assembled from a plurality of form parts arranged in a chain that is partially below ground level to form a foundation perimeter. The form parts are made of a lightweight material such as insulating foam material shaped as an elongated sectional unit with an overhang part overhanging a cavity part of an interior cavity. The interior cavity has an opening for receiving a concrete pour concurrent with a concrete pour of a floor. Open ends of the assembled sectional units abut each other in end-to-end alignment to form an elongated cavity inside the perimeter chain of form parts that is filled with concrete. The overhang part may have a foot shape that fits inside the interior cavity of another form part that may also have a foot shape for compact storage or transport prior to assembly.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: An insulating panel to be used in a panelized insulation system for insulating and finishing walls, including basement walls has a foam core made of inorganic materials. The system incorporates a capillary break, an integrated water drainage system and an electrical wire chase system within an insulating wall panel. Vertical slots are provided for insertion of metal studs for use in attaching the interior finish panel, such as inorganic fiber cement board with a vinyl laminate finish, onto the insulating panels. Embedding metal studs in the panel core reduces the sound transmission though the panel and eliminates thermal bridging between warm and cold surfaces. Steps on the edges and the top/bottom surfaces of the insulating panel allow more panels to join together with shiplap joints.

Abstract: A cover device kit includes: a plurality of heat insulation components comprising a lightweight construction material such as synthetic resin foam capable of being transported in a disassembled state and then quickly assembled into a box-shaped heat barrier structure having six sides including an opening on an open side for covering an opening in a floor or wall of a building. Four of the plurality of heat insulation components 14, 16, 18, 20 each includes two complimentary connections for uniting with two corresponding adjacent heat insulation components of the plurality of heat insulation components when assembled into four side walls of the box-shaped heat barrier structure 10. The cover 12 serves as a fifth heat insulation component and unites with the four components 14, 16, 18, 20 that constitute side walls of the box-shaped structure and is situated opposite the opening on the open side.

Abstract: A permanent frost protected shallow foundation footing for a building is assembled from a plurality of form parts arranged in a chain that is partially below ground level to form a foundation perimeter. The form parts are made of a lightweight material such as insulating foam material shaped as an elongated sectional unit with an overhang part overhanging a cavity part of an interior cavity. The interior cavity has an opening for receiving a concrete pour concurrent with a concrete pour of a floor. Open ends of the assembled sectional units abut each other in end-to-end alignment to form an elongated cavity inside the perimeter chain of form parts that is filled with concrete. The overhang part may have a foot shape that fits inside the interior cavity of another form part that may also have a foot shape for compact storage or transport prior to assembly.