Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.

Abstract: An energy barrier is made of adjustable width insulating rails, reflective insulation panels and a gasketing element to create a single layer or multi-layer stack of reflective dead air spaces within cavity spaces of framing members of a building envelope where an efficient energy barrier is desired.

Abstract: A thermal barrier is formed into a hat-shape by folding sections of an extended length of board formed for assembly and insertion as a barrier to thermal radiation into a space between two joists or studs of a floor, wall, roof, or ceiling of a building for completely covering the space while also covering protruding edges of the joists or studs so as to reduce thermal energy transfer through the joists or studs themselves. A thermal barrier assembly is shown with an outer reflective surface and is also shown for assembly into a form having an inner enclosure for enclosing an inner thermal barrier also having a reflective surface for reducing thermal radiation transfer by reflection and protected from dust by virtue of the enclosure.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: Fan-folded panels are provided with longitudinal cuts or fold lines along an extended length of the panels to enable folding of edge sections of the panels into channel walls on either side of an intermediate panel section together forming a channel having a heat reflective surface inside the channel, the channel for insertion between two facing joists or studs so that tops of the channel walls are pushed up against a facing surface supported by the joists to form an air cavity between the facing surface and the channel acting as the radiant thermal barrier. A hydronic under floor heating pipe may be pre-installed attached to the facing surface supported by the joists or studs with the result that a proper air cavity is maintained with the radiant thermal barrier.

Abstract: A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Abstract: A neck ring for molding a glass container neck finish that includes at least one closure attachment feature. The neck ring includes two semi-annular bi-metal neck ring halves, each consisting essentially of a neck ring insert of wear-resistant metal construction, and a neck ring body of heat-conductive metal construction different from said wear-resistant metal construction and formed around said neck ring insert so as to embed it in said neck ring body. Each of said neck ring halves has a glass-contacting cavity face that includes a first surface portion formed by said inserts for molding the at least one closure attachment feature on the neck finish, and a second surface portion formed by said bodies for molding portions of the neck finish excluding the at least one closure attachment feature.

Abstract: The claimed subject matter relates to architectures and/or mechanisms that can facilitate issuing, embedding and verification of an optical DNA (o-DNA) signature. A first mechanism is provided for obtaining a set of manufacturing errors inherent in an optical media instance. These errors can be encoded into the o-DNA that can be cryptographically signed with a private key, then embedded into the source optical media instance. A second mechanism is provided that can decrypt the o-DNA with a public key and compare the authenticated errors to the observed errors to ascertain whether the optical media instance is authentic as opposed to a forgery or counterfeit.

Abstract: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Abstract: A fan-folded insulating board laminate comprises an extended length of synthetic resin foam board having longitudinal edges and protective skins adhered to each surface of the foam board. Reinforcing strips are spaced along both of the longitudinal edges of the laminate and are bonded to both of the skins. They extend about the longitudinal edges, and the laminate has a series of longitudinally spaced cuts through the board and alternately through one of the protective skins. The uncut skin and strip act as a hinge between adjacent sections of the board to enable fan-folding of the laminate.

Abstract: A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.

Abstract: A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.

Abstract: Described is a composition with low toxicity comprising an amphipathic compound and a polycation, useful for delivering siRNA to a cell. The composition may be used in the process of delivering a siRNA to an animal cell, or more particularly a mammal cell, in a multi-well format.

Abstract: Thermal conductivity of glassware forming blank molds and blow molds of Ni-Resist ductile iron is selectively controlled by formation of compacted graphite in the mold microstructure during preparation of the melt and casting of the mold bodies. Specifically, with a Type D5 Ni-Resist ductile iron according to ASTM-A439-84, compacted graphite is selectively formed in the cast microstructure of the mold body by reducing the magnesium and sulphur concentrations in the iron composition to the range of 0.01 to 0.04 wt % magnesium and 0.00 to 0.01 wt % sulphur, and adding titanium to the iron composition in the range of 0.10 to 0.25 wt % titanium. Whereas formation of compacted graphite in the cast microstructure is normally considered to be undesirable for glassware forming molds, it has been found that formation of a small but appreciable amount of graphite provides the opportunity selectively to tailor the thermal conductivity characteristics of the mold body.

Abstract: The process comprises designing a polynucleotide, such as an siRNA, for transfection. The polynucleotide is inserted into a mammalian vessel such as an artery. Prior to insertion, subsequent to insertion, or concurrent with insertion volume in the vessel is increased allowing the polynucleotide delivery to the parenchymal cell.